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Karl Oskar Illmensee (1939–)
By: Cheryl Lancaster
| Published: Feb 26, 2017
Karl Oskar Illmensee studied the cloning and reproduction of fruit flies, mice, and humans in the US and Europe during the twentieth and twenty-first…
CloningMolecular CloningClone CellsTwinsEmbryos
Translational Developmental Biology
By: Mary E. Sunderland
| Published: Jun 10, 2009
Translational developmental biology is a growing approach to studying biological phenomena that explicitly aims to develop medical therapies. When…
medicineStem Cells
“Pregnancy Established in an Infertile Patient After Transfer of a Donated Embryo Fertilized In Vitro” (1983), by Alan Trounson, John Leeton, Mandy Besanko, Carl Wood, and Angelo Conti
By: Whitney Alexandra Tuoti
| Published: Apr 13, 2021
In 1983, researchers Alan Trounson, John Leeton, Carl Wood, Mandy Besanko, and Angelo Conti published the article “Pregnancy Established in an…
LiteratureFertilization in VitroIn vitro fertilizationEgg donorsTest-Tube Babies
Mitochondrial DNA (mtDNA)
By: Dorothy R. Haskett
| Published: Dec 19, 2014
Mitochondrial DNA (mtDNA) is located outside the nucleus in the liquid portion of the cell (cytoplasm) inside cellular organelles called Mitochondria…
Mitochondrial DNAMitochondriaMitochondrial DisordersMitochondrial pathologyMitochondrial DNA--Abnormalities
Nuclear Transplantation
By: Sean Cohmer
| Published: Jun 14, 2011
Nuclear transplantation is a method in which the nucleus of a donor cell is relocated to a target cell that has had its nucleus removed (enucleated…
Cell nuclei--TransplantationNuclear Transplantation
"CRISPR /Cas9-mediated Gene Editing in Human Tripronuclear Zygotes" (2015), by Junjiu Huang et al.
By: Meilin Zhu
| Published: Nov 08, 2017
In 2015, Junjiu Huang and his colleagues reported their attempt to enable CRISPR/cas 9-mediated gene editing in nonviable human zygotes for the first…
LiteratureDoudna, Jennifer A.Charpentier, Emmanuelle, 1968-Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas Systems
"Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (t12/t12)-Normal Mosaics" (1964), by Beatrice Mintz
By: Adam R. Navis
| Published: Jan 13, 2009
The paper "Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (t12/t12)-Normal Mosaics," by Beatrice Mintz, describes a…
Mintz, BeatriceExperimentsMice
Alexis Carrel's Tissue Culture Techniques
By: Lijing Jiang
| Published: Jun 18, 2010
Alexis Carrel, the prominent French surgeon, biologist, and 1912 Nobel Prize laureate for Physiology or Medicine, was one of the pioneers in…
TechnologyCarrel, Alexis, 1873-1944Tissue Culture TechniquesTissue culture
The French Flag Model
By: Jack Resnik
| Published: May 19, 2011
The French flag model represents how embryonic cells receive and respond to genetic information and subsequently differentiate into patterns. Created…
ModelsGenetics
Beatrice Mintz (1922–2022)
By: Adam R. Navis
| Published: Jan 21, 2009
Beatrice Mintz is a brilliant researcher who has developed techniques essential for many aspects of research on mouse development. She produced the…
PeopleBiographyMiceCancer