In 1981, Frank Addiego and colleagues published “Female Ejaculation: A Case Study” in The Journal of Sex Research. In the article, the authors find that female ejaculation, or the expulsion of fluid from a female’s urethra during or before orgasm, is a legitimate phenomenon that can occur when one stimulates an area in the vaginal wall that the team names the Gräfenberg-spot. According to the authors, at the time of publication, many individuals believed that if a female expelled fluid during orgasm, the fluid was urine and, thus, improper bladder control caused the expulsions. However, in “Female Ejaculation: A Case Study,” the researchers explain that they collected samples of one woman’s orgasmic fluid and compared its chemical composition to that of her urine, and they found that the two fluids were different. In their case study, Addiego and colleagues not only provide evidence that female ejaculation is a legitimate physiological response, but they also support the idea that females who experience it are not defective, which helped to shape social views and future research on the female orgasm.

In 1950, physician and researcher Ernst Gräfenberg published “The Role of Urethra in Female Orgasm,” in the International Journal of Sexology. The article was one of the first to mention the area in the anterior, or front, vaginal wall colloquially called the G-spot. In the article, Gräfenberg acknowledges that many females experience problems related to sexual satisfaction, and he argues that researchers and physicians of the time did not know enough information about the anatomical mechanisms and localization of the female orgasm to help them. He claims that there is a distinct zone in the anterior vaginal wall along the urethra that plays a critical role in female sexual pleasure, making it important for physicians to consider when treating females’ sexual problems. Though researchers are still debating the structural existence of the G-spot as of 2022, “The Role of Urethra in Female Orgasm” was one of the first publications to explore the anatomical elements of the female orgasm, and it led to further research about female sexuality that has helped many individuals to better understand female pleasure.

In 2005, Helen O’Connell and colleagues published “Anatomy of the Clitoris,” a review article, in The Journal of Urology. The article was one of the first to provide a complete anatomical description of the clitoris, which is the organ involved in female sexual pleasure. In addition, O’Connell and her team relay that researchers have historically misunderstood and misrepresented the anatomy of the clitoris. They point out that even though researchers began accurately describing the anatomy of the clitoris in the 1840s, most anatomy textbooks in 2005 still omitted or inaccurately described the structure. The team argues that those omissions not only hinder surgeons’ ability to perform surgery on the clitoris but also reflect a dominant culture of misvaluing the female body. “Anatomy of the Clitoris” helps correct historical misconceptions about clitoral anatomy and promotes accurate representation of female anatomy in educational textbooks and academic settings.

Metoidioplasty is a type of gender-affirming surgery that creates a small-sized neophallus, or new penis, from an enlarged clitoris. Gender-affirmation surgeries are procedures that alter a person’s body, typically sexual characteristics like the genitals, to align a person’s sex with their gender identity so that they can move through society more comfortably. Such procedures treat gender dysphoria, which is the distress or discomfort that may be felt by transgender people. Transgender people’s gender identities differ from the genders they were assigned at birth, usually conflated with the sex they were assigned at birth. As opposed to a phalloplasty, a procedure where a neophallus is created using tissue from other areas of the body and not just the existing genital tissues, metoidioplasty allows transgender individuals to have a penis with less noticeable scarring, preservation of erogenous sensation, and, if the patient desires, the ability to urinate while standing. The technique was first suggested in 1973, then performed in 1974, however, doctors and researchers did not refer to it as metoidioplasty until 1989. Since its implementation, several modifications have ensured lower risks and better results for patients. Metoidioplasty improves the quality of life for people seeking gender-affirmation surgery by treating gender dysphoria.