A vasectomy is a surgery that works to inhibit reproduction by interrupting the passage of sperm through the vas deferens, a tube in the male reproductive system. The procedure is a method of inhibiting an individual’s ability to cause pregnancy through sexual intercourse without altering the other functions of the penis and testes. In the US, into the early 1900s, proponents of eugenics, the belief that human populations can be made better by selecting for so-called desirable traits, used the procedure to forcibly sterilize people whom they deemed undesirable. Despite its early associations with eugenics, physicians’ use of vasectomy eventually transitioned into an option for elective contraception. Even with the various shifts in motivation for performing vasectomies, as of 2023, patients have the choice to undergo a sterilization procedure if they want to restrict their own ability to have children.

X-linked severe combined immunodeficiency, or X-SCID, is a chromosomal disorder in which the immune system lacks multiple protective cells that defend the body from disease. As of 2024, approximately one in 75,000 males have X-SCID. X-SCID is the most common type of SCID, which encompasses a range of disorders that all involve defects in immune cells that fight infections, leaving the individual susceptible to life-threatening diseases. X-SCID, which typically only affects males, arises due to a mutation in the interleukin 2 receptor gamma chain, or IL-2RG, gene on the X chromosome. IL-2RG aids certain immune cells to develop their protective functions, so a mutation in the receptor results in a dysfunctional immune system. Doctors most commonly use bone marrow transplants to treat X-SCID. By studying cases of X-SCID, researchers more clearly defined the role of lymphocytes in immune system development and overall disease protection. Unless detected and treated early, the defect in immune cells from X-SCID makes the individual prone to severe, recurrent infections, which are almost always fatal.

Gonorrhea is a sexually transmitted disease, or STD, caused by the bacterium Neisseria gonorrhoeae. Common symptoms of the disease include painful urination and genital discharge. There are records of historical discussions of gonorrhea in ancient civilizations and during the Middle Ages, but scientists did not begin investigating the scientific causes and treatments of the STD until the sixteenth century. In the 1700s, physicians attributed gonorrhea to the same cause as another STD, syphilis. Later, in the 1800s, researchers discovered the two diseases were not the same and identified the bacteria N. gonorrhoeae that causes gonorrhea. By the 1900s, researchers began using antibiotics to target the bacteria, but many drugs eventually developed antibiotic resistance. In 2020, the World Health Organization, or WHO, estimated that 82.4 million individuals contracted gonorrhea globally, and as of 2024, researchers continue to experiment with various antibiotic drugs to provide adequate treatment for the disease.

Menopause is defined as the point in time exactly twelve months after a female has had her last menstrual period, or shedding of the lining of the uterus. As a female ages, the hormone levels that drive menstruation decrease, beginning the process of perimenopause, which eventually leads to menopause and can result in various symptoms including depression, difficulty sleeping, and hot flashes, or abrupt feelings of heat typically in the upper body. Once a female reaches menopause, those symptoms typically subside, but after menopause, the risk of other health conditions such as osteoporosis, or brittle bones, increases. At least since the fourth century BCE, researchers understood that menopause occurred in females but held many negative ideas and misconceptions about the process, which resulted in stigma that left females uninformed about what happened to their bodies as they aged. Research on and perceptions towards menopause evolved over the twentieth century, and as of 2024, researchers understand it as a typical part of aging and development in females, marking the end of their reproductive years.

The Gräfenberg spot, or the G-spot, is thought to be an area in the anterior, or front, vaginal wall that contributes to sexual pleasure. Ernst Gräfenberg became one of the first individuals to discuss the G-spot in 1950, and he claimed that the area is a distinct part of the vagina that plays a key role in orgasm. In 1981, researchers echoed Gräfenberg’s conclusion about the area’s existence and function, and they named it the Gräfenberg spot, or G-spot, after him. As of 2024, the media often portrays the G-spot as an area that is well-characterized, but scientific data on the G-spot is actually fairly inconclusive. Though researchers agree that the G-spot contributes to sexual pleasure in some individuals, they continue to debate about its functions and characteristics. Scientific debate about the G-spot produced research that has helped people to better understand the anatomical elements of the female orgasm, thus improving medical knowledge of female sexual health and pleasure.