Ovarian hyperstimulation syndrome, abbreviated OHSS, is an atypical reaction that women may experience in response to excessive hormones, and often occurs during fertility treatments. OHSS is typically triggered by hormonal medications designed to mature eggs in the ovaries, which can cause blood vessels within the ovaries to leak fluid. Sometimes that can lead to painful tenderness or swelling. In severe cases of OHSS, that fluid can leak into the abdominal cavity in large amounts, causing vomiting, blood clots, and severe pain. As many as one out of three women undergoing fertility treatment will experience some form of OHSS, although more severe presentations are rare. While the exact cause of OHSS is not fully understood as of 2020, researchers continue to discover various risk factors, prevention techniques, and treatments that may lead to decreased risks associated with OHSS and better fertility outcomes.

Gestational diabetes is a medical condition that causes blood sugar levels to become abnormally high, which manifests for the first-time during pregnancy and typically disappears immediately after birth for around ninety percent of affected women. While many women with the condition do not experience any noticeable symptoms, some may experience increased thirst and urination. Although gestational diabetes is treatable, if left unmanaged, the resulting fetus is more likely to have elevated risks of increased birth weight, birth injuries, low blood sugar, stillbirth, and later development of type 2 diabetes. The International Diabetes Federation estimates that worldwide in 2019, gestational diabetes affected one in six pregnant women, with many cases occurring in women living in low and middle-income countries. Despite the prevalence and risks associated with gestational diabetes, as of 2020, researchers have yet to reach a unified consensus on the best guidelines for diagnosis and treatment.

In 1974, the United States Supreme Court decided in a six-to-three decision in Geduldig v. Aiello (1974), hereafter Geduldig, that pregnancy-related disabilities could be excluded from state-run disability insurance programs and that discrimination based on pregnancy did not constitute sex discrimination. Carolyn Aiello, a woman denied disability benefits in California since her disability was pregnancy-related, and three other women facing similar discrimination, sued Dwight Geduldig, director of the California Department of Human Resources Development for violating the equal protection clause of the Fourteenth Amendment. Under California’s Unemployment Insurance Code at the time, conditions or disabilities that arise from or are related to a pregnancy were excluded from coverage. Aiello and the other women argued that by not insuring pregnancy-related disabilities, the state was unfairly discriminating against women. Geduldig detached pregnancy discrimination from the injustices uniquely faced by women by determining that civil rights law did not apply to pregnancy status, exacerbating the inequality women in the United States face in employment, education, and economic opportunity.