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Calvin Bridges’ Experiments on Nondisjunction as Evidence for the Chromosome Theory of Heredity (1913-1916)
By: Kevin Gleason
| Published: May 18, 2017
From 1913 to 1916, Calvin Bridges performed experiments that indicated genes are found on chromosomes. His experiments were a part of his doctoral…
DrosophilaHeredityInheritance of acquired charactersColumbia University--Graduate studentsMutation
Using Digital PCR to Detect Fetal Chromosomal Aneuploidy in Maternal Blood (2007)
By: Meilin Zhu
| Published: Nov 08, 2017
In 2007, Dennis Lo and his colleagues used digital polymerase chain reaction or PCR to detect trisomy 21 in maternal blood, validating the method as…
Polymerase chain reactionNucleic Acid Amplification TechniquesDown syndromeDNAAneuploidy
“Sex Limited Inheritance in Drosophila” (1910), by Thomas Hunt Morgan
By: Kevin Gleason
| Published: May 22, 2017
In 1910, Thomas Hunt Morgan performed an experiment at Columbia University, in New York City, New York, that helped identify the role chromosomes…
DrosophilaHeredityInheritance of acquired charactersColumbia University--Graduate studentsMutation
"Male Development of Chromosomally Female Mice Transgenic for Sry gene" (1991), by Peter Koopman, et al.
By: Troy Cox
| Published: Jan 28, 2014
Early 1990s research conducted by Peter Koopman, John Gubbay, Nigel Vivian, Peter Goodfellow, and Robin Lovell-Badge, showed that chromosomally…
Y ChromosomeTestisEmbryosChromosomesSex Chromosomes
"The linear arrangement of six sex-linked factors in drosophila, as shown by their mode of association” (1913), by Alfred Henry Sturtevant
By: Kevin Gleason
| Published: May 22, 2017
In 1913, Alfred Henry Sturtevant published the results of experiments in which he showed how genes are arranged along a chromosome. Sturtevant…
DrosophilaHeredityInheritance of acquired charactersColumbia University--Graduate studentsMutation
Barbara McClintock's Transposon Experiments in Maize (1931–1951)
By: Federica Turriziani Colonna
| Published: Feb 09, 2017
Barbara McClintock conducted experiments on corn (Zea mays) in the United States in the mid-twentieth century to study the structure and function of…
TransposonsCornCytogeneticsChromosomesGenetics
“A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation” (1993), by Dean H. Hamer and Charles A. Thomas.
By: Christina Nguyen
| Published: Apr 13, 2017
In 1993, Dean H. Hamer and colleagues in the US published results from their research that indicated that men with speicifc genes were more likely to…
HomosexualityMale homosexualityGeneticsX chromosomeGenetic sex determination
"Genetic Evidence Equating SRY and the Testis-Determining Factor" (1990), by Phillippe Berta et al.
By: Troy Cox
| Published: Jan 10, 2014
In the late 1980s, Peter Goodfellow in London, UK led a team of researchers who showed that the SRY gene in humans codes a protein that causes testes…
TestisY ChromosomeEmbryosChromosomesSex Chromosomes
Serial Cultivation of Human Diploid Cells in the Lab (1958–1961) by Leonard Hayflick and Paul S. Moorhead
By: Christian H. Ross
| Published: Apr 27, 2017
From 1958 to 1961, Leonard Hayflick and Paul Moorhead in the US developed a way in the laboratory to cultivate strains of human cells with complete…
MMR VaccineRubellaRubella--VaccinationFetal tissuesOncogenic Viruses
Hermann Joseph Muller's Study of X-rays as a Mutagen, (1926-1927)
By: Kevin M. Gleason
| Published: Mar 07, 2017
Hermann Joseph Muller conducted three experiments in 1926 and 1927 that demonstrated that exposure to x-rays, a form of high-energy radiation, can…
X-raysRadiationGeneticsMutationDrosophila