Leuprolide acetate, or leuprorelin, is a manufactured drug that has been prescribed as a treatment for endometriosis, a medical condition in which body tissue that typically lines the uterus grows outside of the uterus, since 1989. Leuprorelin is a modified version of a gonadotropin-releasing hormone, a type of hormone that helps regulate the female menstrual cycle. The drug inhibits the production of estrogen, a female sex hormone that enables endometrial gland growth. After two weeks of injections, leuprorelin stops the production of estrogen, and without estrogen, endometrial glands become inactive. That decreases the growth of uterine tissue outside of the uterus, which helps decrease the pain associated with endometriosis. Although physicians commonly prescribe leuprorelin as of 2019, women with endometriosis have reported adverse side effects and health complications.

Menstrupedia published the comic book Menstrupedia Comic: The Friendly Guide to Periods for Girls, hereafter Menstrupedia Comic, in July 2014 in India. Aditi Gupta, the founder of Menstrupedia and a women’s health activist, wrote Menstrupedia Comic while studying at the National Institute of Design in Gujarat, India, in 2013. Gupta worked alongside her husband, graphic designer Tuhin Paul, who provided the illustrations for the book. According to Menstrupedia, misconceptions and taboo surrounding menstruation in India prompted Gupta to develop the book. Specifically, in Hindu culture, women and girls may feel embarrassed to discuss their menstrual cycles openly, because menstruation is a process that some people consider impure. Published in eleven different languages, Menstrupedia Comic has become an educational resource for girls around the world to learn about their menstrual cycles.