In 1904, physician William Henry Walling published Sexology, a family medicine reference book. In his book, Walling proposed that his guidance would help people who were married or single and young or old, as well as anyone who wanted to conform to, what he claims are, gender expectations. Sexology discusses issues such as masturbation, abortion, pregnancy, labor, and marriage. Despite Walling’s limited scientific explanations and evidence for his medical claims, the Puritan Publishing Company printed and distributed the book, which received many positive reviews and endorsements from other physicians, college presidents, politicians, and religious leaders. However, in the twenty-first century, people may consider many of Walling’s claims to be sexist and oppressive toward women. Sexology provides readers with examples of historical medical misconceptions of male and female anatomy and provides context for the logic of reproductive medicine at the turn of the twentieth century.

Henry Havelock Ellis was born on 2 February 1859 at Croydon in Surrey, England, to Susannah Wheatley Ellis and Edward Peppen Ellis, a sea captain. A psychologist, essayist, and physician, he is best known for his contributions to the study of human sexuality and his support of sex education and women's rights. Ellis 's work catalyzed the revolution against repressive Victorian views of sexuality. He was practicing and writing during an era in which attitudes about sex were beginning to change thanks to the activism of several key players in the fight for sexual equality and controlled reproduction. The rise of the more liberal modern approach to human sexuality seen in the first half of the twentieth century is due largely to the efforts of Ellis and other reproductive rights champions like Margaret Sanger and Marie Stopes.

Christine Jorgensen was a transgender woman and activist in the United States who lived during the twentieth century. She was one of the first US citizens to publicly disclose her gender transition from male to female through gender-affirming surgery and hormone replacement therapy. By 1949, when Jorgensen began her transition, few individuals had undergone gender transition. Various popular media outlets reported on Jorgensen’s gender transition and surgery, which allowed Jorgensen to educate the American public on topics such as gender identity and sexual orientation. Jorgensen authored an autobiography in 1967, which detailed the journey of her life from early childhood to the end of her forties. Although many transgender people continue to fight for acceptance and equality in the US as of 2024, Jorgensen’s advocacy and activism increased transgender awareness for the general public at a time when existing and living openly as a transgender person received little recognition and support.