In 2021, Brooke Wilson and colleagues published “Oral Administration of Maternal Vaginal Microbes at Birth to Restore Gut Microbiome Development in Infants Born by Caesarean Section: A Pilot Randomised Placebo-controlled Trial,” hereafter “Oral Administration,” in eBiomedicine. Previous researchers had established that neonates born via caesarean section, or c-section, the surgical delivery of an infant through an incision made in the mother’s abdomen, have different gut microbiomes from neonates delivered vaginally. They further hypothesized that such a difference may be because infants born by c-section do not receive exposure to their mother’s vaginal microbiome during delivery. Thus, Wilson and colleagues investigate whether oral vaginal seeding, or the process of transferring vaginal microbes to a newborn’s mouth, can restore the gut microbiome of newborns born by c-section. “Oral Administration” was one of the first articles to demonstrate that oral vaginal seeding is ineffective in altering the gut microbiome of newborns delivered by c-section and prompted other researchers to explore alternative research routes to enhancing the gut microbiome of newborns born by c-section.