In 2021, the World Health Organization, or WHO, published the sixth edition of their Laboratory Manual for the Examination and Processing of Human Semen, which provides standardized guidelines to physicians and other medical professionals performing semen analysis. Semen analysis is a technique that medical professionals use to analyze the characteristics of a male’s semen and sperm cells to identify possible causes of male infertility. A sperm cell is the male sex cell that fertilizes a female’s egg cell, while semen is the fluid containing sperm cells that men release during ejaculation. The WHO created the first laboratory manual for semen analysis in 1980, a time when there was no standardized way to analyze a male’s semen sample. The WHO laboratory manual was one of the first documents to standardize a procedure for evaluating human semen to look for sperm abnormalities, and it remains one of the most widespread methods of evaluating a male’s fertility potential and determining the causes of male infertility.

Simplifying science means more than just making science understandable for people of lower chronological age, it also encompasses making science more accessible to people with a lower educational age. Through their “Embryo Tales,” Ask a Biologist discusses topics such as fetal alcohol syndrome, ectopic pregnancies, polio, etc. and the science behind them in an easy-to-understand manner. The Ask a Biologist materials are directed at a younger audience in terms of educational age compared to most textbooks and other sources, which allows them to communicate information to people who otherwise may not comprehend the science at hand. As Ask a Biologist states, their main goal is to “increase communication between scientists and the public” (Ask a biologist). They increase the cognition of the public by using a readability level checker to keep each sentence easy to understand, implementing well thought-out analogies throughout the article, incorporating helpful pictures, and including an engaging, related story at the beginning of each article. This thesis explains studies both for and agains those techniques aiming to make science-related topics more understandable. The thesis encompasses some of my own Embryo Tales with an analysis of them, highlights my role in shaping Embryo Tales into what they are today, and also details how I will apply what I learned to my career as a future physician.

In December of 2016, Margus Punab and colleagues published “Causes of Male Infertility: A 9-year Prospective Monocentre Study on 1737 Patients with Reduced Total Sperm Counts,” hereafter “Male Infertility,” in the journal Human Reproduction. The study examines the main causes of severe male factor infertility, or SMF infertility, which occurs when a male’s semen has a very low number of healthy sperm cells or contains atypically low levels of sperm cells. In “Male Infertility,” the authors determine the primary cause of SMF infertility in forty percent of their participants, and among those participants, they found that the primary causes of SMF infertility were varicoceles, or enlarged veins within the loose bag of skin holding the testicles. The authors did not determine the cause of SMF infertility in the remaining sixty percent of the cases, noting a gap in the current understanding of the causes of SMF infertility. “Male Infertility” was one of the first large-scale studies to reveal certain underlying causes of SMF infertility, and its conclusions have allowed researchers to investigate fertility solutions for male patients who would otherwise not be able to reproduce.