In 1928 Ezra Seymour Gosney founded the non-profit Human Betterment Foundation (HBF) in Pasadena, California to support the research and publication of the personal and social effects of eugenic sterilizations carried out in California. Led by director Gosney and secretary Paul Popenoe, the HBF collected data on thousands of individuals in California who had been involuntarily sterilized under a California state law enacted in 1909. The Foundation's assets were liquidated following Gosney's death in 1942. In 1943, Gosney's daughter donated the remaining assets to the California Institute of Technology (Caltech) in Pasadena, California to establish the Gosney research fund for biological research. Between 1928 and 1942, the HBF published extensively on what they believed to be the benefits of sterilization to both patient and society. The HBF and its members existed within the larger context of the American eugenics movement and scientific institutions, including the Eugenics Record Office at Cold Spring Harbor Laboratory in Cold Spring Harbor, New York, which bolstered the movement's goals of the control of human reproduction and human heredity. Moreover, the model sterilization legislation written by the HBF was disseminated throughout the world to eugenics enthusiasts eager to pass laws limiting the reproduction of people they considered to be unfit.

The American Eugenics Society (AES) was established in the US by Madison Grant, Harry H. Laughlin, Henry Crampton, Irving Fisher, and Henry F. Osborn in 1926 to promote eugenics education programs for the US public. The AES described eugenics as the study of improving the genetic composition of humans through controlled reproduction of different races and classes of people. The AES aided smaller eugenic efforts such as the Galton Society in New York, New York, and the Race Betterment Foundation in Battle Creek, Michigan, and it influenced eugenic policy set by the US Supreme Court in cases including Buck v. Bell (1927) and Skinner v. Oklahoma (1942). The AES was renamed the Society for the Study of Social Biology in 1972.

Harry Hamilton Laughlin helped lead the eugenics movement in the United States during the early twentieth century. The US eugenics movement of the early twentieth century sought to reform the genetic composition of the United States population through sterilization and other restrictive reproductive measures. Laughlin worked as superintendent and assistant director of the Eugenics Research Office (ERO) at Cold Spring Harbor Laboratory in Cold Spring Harbor, New York, alongside director Charles Davenport. During Laughlin's career at the ERO, Laughlin studied human familial ancestry, called pedigrees, and in 1922 published the book Eugenical Sterilization in the United States, which influenced sterilization laws in multiple states. Laughlin's support of compulsory sterilization to control the reproductive capacity of entire populations influenced the history of eugenics and reproductive medicine.

Madison Grant was a lawyer and wildlife conservationist who advocated for eugenics policies in the US during the late nineteenth and early twentieth centuries. In his 1916 book, The Passing of the Great Race; or, The Racial Basis of European History, Grant argued that what he called the Nordic race, which originated from northwest Europe, was biologically and culturally superior to all other people, including other Europeans. Grant drew from his now-discredited claims to lobby for laws in the US that restricted immigration, legalized sterilizing people against their will, and prohibited interracial marriage. Adolf Hitler referred to Grant’s book as his Bible and it was listed during the Nuremberg Trials in the late 1940s as evidence that eugenics did not solely originate in Germany. Grant’s advocacy of eugenics shaped policy that restricted reproductive freedom and immigration in the US and helped legitimize genocide in Europe.

In 1916, eugenicist Madison Grant published the book The Passing of the Great Race; or The Racial Basis of European History, hereafter The Passing of the Great Race, where he claimed that northern Europeans, or Nordics, are biologically and culturally superior to the rest of humanity. Charles Scribner’s Sons in New York City, New York, published the volume. Grant claimed that the Nordic race was at risk of extinction and advocated for the creation of laws in the US to decrease the population of people he considered inferior. According to Grant’s biographer Jonathan Spiro, Grant’s book synthesized a range of racist and pseudoscientific eugenics claims in prose that was accessible to the public. In the US, The Passing of the Great Race was praised by politicians, including former presidents Theodore Roosevelt and Calvin Coolidge, and cited as justification for laws that restricted immigration based on ethnicity and nationality. Adolf Hitler referred to The Passing of the Great Race as his Bible, and during the Nuremberg Trials in the 1940s, Nazi leaders who were prosecuted for war crimes committed during World War II presented the book as evidence that eugenics did not solely originate in Germany but rather had deep roots in the United States.

The International Eugenics Congresses consisted of three scientific meetings held in London, England, in 1912 and at the American Museum of Natural History in New York City, New York, in 1921 and 1932. Leonard Darwin, son of Charles Darwin, Henry Fairfield Osborn, the President of the American Museum of Natural History, and Charles Benedict Davenport, founder of the Eugenics Record Office at Cold Spring Harbor Laboratory in New York City presided over the Congresses. Scientists presented research in genetics and shared ideas for putting eugenics into practice, such as preventing people they considered inferior from reproducing through forced sterilization. The three International Eugenics Congresses increased scientific and public support of the eugenics movement in the early twentieth century, and established organizations to pursue eugenics agendas that contributed to the forced sterilization of hundreds of thousands of people in the US and Nazi Germany.