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In 1963, Ignacio Ponseti and Eugene Smoley experimentally determined an effective and minimally invasive method of treating congenital clubfoot.…
ClubfootFoot--AbnormalitiesOrthopedicsCongenital Talipes EquinovarusClubfoot, CongenitalIn 1952, researchers Christopher Polge and Lionel Edward Aston Rowson, who worked at the Animal Research Center in Cambridge, England, detailed…
GlycerinCryopreservationSpermatozoaMicroorganisms--CryopreservationExperimentsBetween 1935 and 1937, Leonard Colebrook showed that sulfonamides, a class of antibacterial drugs, worked as an effective treatment for puerperal…
Puerperal septicemiaSulfonamidesMedical Research Council (Great Britain)Streptococcus agalactiaeStreptococcus pyogenesBetween 1958 and 1962, physicians Olive W. Smith, George V. Smith, and Robert W. Kistner performed experiments that demonstrated the effects of the…
EthamoxytriphetolEstrogen AntagonistsClomiphenePituitary glandovaryFrom February 2003 to December 2010, researchers of the Management of Myelomeningocele Study, or MOMS, clinical trial compared the safety and…
MeningomyeloceleSpina Bifida CysticaSpina BifidaNewborn infants--SurgeryHydrocephalusIn 2007, Philippe Horvath and his colleagues explained how bacteria protect themselves against viruses at Danisco, a Danish food company, in Dangé-…
gene editingStreptococcus thermophilusvirusesBacteriaRNAIn 2007, Dennis Lo and his colleagues used digital polymerase chain reaction or PCR to detect trisomy 21 in maternal blood, validating the method as…
Polymerase chain reactionNucleic Acid Amplification TechniquesDown syndromeDNAAneuploidyIn 2015, Junjiu Huang and his colleagues reported their attempt to enable CRISPR/cas 9-mediated gene editing in nonviable human zygotes for the first…
LiteratureDoudna, Jennifer A.Charpentier, Emmanuelle, 1968-Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsIn 2012, Jennifer Doudna, Emmanuelle Charpentier from the University of California, Berkeley, in Berkeley, California, and Umeå University in Umeå,…
gene editingStreptococcus pyogenesTranscription Activator-Like Effector NucleasesscFV green fluorescent protein, recombinantClustered Regularly Interspaced Short Palindromic RepeatsFrom 1993 to 1995 researchers led by Robert J. Berry from the US Centers for Disease Control headquartered in Atlanta, Georgia, and Zhu Li from…
Center for Disease ControlFolic AcidFolic Acid DeficiencyFolic acid in human nutritionNeural tube--Abnormalities