George Frederic Still studied pediatrics and childhood conditions in England during the early twentieth century. In Still’s time, pediatrics, or the branch of medicine that focuses on treating and caring for children, remained largely unexplored according to biographer Joseph deBettencourt. Still helped advance pediatrics as a field by classifying and writing about diseases and conditions that arose in children. In 1897, he discovered a unique type of arthritis in children, now referred to as Still’s disease. Still also was one of the first to correctly describe what is now known as attention deficit hyperactivity disorder, or ADHD, a disorder that can cause children to act impulsively and have trouble focusing, among other behaviors. He shared his understanding of those conditions and pediatrics as a whole in a popular textbook called Common Disorders and Diseases of Childhood. Still’s work helped establish pediatrics as a separate field of medicine and provide a foundation for pediatricians throughout the twentieth century to understand and expand on a variety of conditions developing children can face.
In the late nineteenth century, the Comstock Act of 1873 made the distribution of contraception illegal and classified contraception as an obscenity. Reflecting the predominant attitude towards contraception at the time, the Comstock Act was the first federal anti-obscenity law that targeted contraception. However, social acceptance of birth control changed at the turn of the twentieth century. In this thesis, I analyzed legislation, advocates, and literature pertinent to that social change to report on the events leading up to the decriminalization of contraception.
Edwin Carlyle Wood, also known as Carl Wood, was a physician who helped develop in vitro fertilization, or IVF, treatments. From 1964 to 1992, Wood worked as a professor of obstetrics and gynecology at Monash University in Melbourne, Australia, where he was one of the first in the world to lead a team of physicians to establish IVF as a proven treatment for infertility. IVF refers to a medical procedure in which scientists inseminate an egg cell with a sperm cell outside of the body, such as in a glass dish in a clinical setting. Wood helped establish some of the first successful IVF pregnancies and births, and his findings throughout his years of practice helped to standardize the procedure. Wood also advocated for the right for women to have an abortion, and co-founded the Family Planning Association of Victoria in Australia at a time when there were not many abortion clinics in operation. Through his early contributions to IVF, Wood provided new options for people to have offspring, which as of 2021, has up to a 21.3 percent chance of producing a live birth.
Franklin William Stahl studied DNA replication, bacteriophages, and genetic recombination in the US during the mid-twentieth and early twenty-first centuries. With his colleague Matthew Meselson, Stahl performed an experiment called the Meselson-Stahl experiment, which provided evidence for a process called semi-conservative DNA replication. Semi-conservative replication is a process in which each strand of a parental DNA double helix serves as a template for newly replicated daughter strands, so that one parental strand is conserved in every daughter double helix. Those findings supported the Watson-Crick Model for DNA replication proposed in 1953 by James Watson and Francis Crick, convincing many biologists about DNA’s structure and replication in the 1950s. Stahl’s genetics research, especially that of DNA replication, showed researchers how genetic information is distributed within a cell and is passed down from cell to cell.
Joseph Bolivar DeLee was an obstetrician in the US between the nineteenth and twentieth centuries who advocated for the specialized teaching of medical students in the field of obstetrics to address problems occurring during pregnancy. He claimed obstetricians maintained a wider skillset than midwives, and founded the Chicago Lying-In Hospital to provide affordable obstetric care to women in Chicago, Illinois. According to Carolyn Herbst Lewis, critics of DeLee’s practices often cite his 1920 article, “The Prophylactic Forceps Operation,” as catalyzing a cultural shift toward overly clinical birthing practices. However, rather than solely advocating for its use, he had cautioned against the extreme use of forceps during delivery, and emphasized that obstetricians needed to know the information in the case it could ever save a woman’s life. Though some of DeLee’s philosophies were controversial, such as his disapproval of midwifery, he provided the emerging specialization of obstetrics with new technologies and interventions, cleanliness standards, and the introduction of film as a teaching method.
In 2002, after applying for government assistance in the state of Washington, Lydia Fairchild was told that her two children were not a genetic match with her and that therefore, biologically, she could not be their mother. Researchers later determined that the genetic mismatch was due to chimerism, a condition in which two genetically distinct cell lines are present in one body. The state accused Fairchild of fraud and filed a lawsuit against her. Following evidence from another case of chimerism documented in The New England Journal of Medicine in a woman named Karen Keegan, Fairchild was able to secure legal counsel and establish evidence of her biological maternity. A cervical swab eventually revealed Fairchild’s second distinct cell line, showing that she had not genetically matched her children because she was a chimera. Fairchild’s case was one of the first public accounts of chimerism and has been used as an example in subsequent discussions about the validity and reliability of DNA evidence in legal proceedings within the United States.
Henry Herbert Goddard was a psychologist who conducted research on intelligence and mental deficiency at the Vineland Training School for Feeble-Minded Boys and Girls in Vineland, New Jersey during the early twentieth century. In 1908, Goddard brought French psychologist Alfred Binet and physician Theodore Simon’s intelligence test to the US and used it to investigate intellectual disability in children at the Vineland Training School for Feeble-Minded Boys and Girls. Goddard also wrote a book in 1912 called The Kallikaks: A Study in the Heredity of Feeble-Mindedness, claiming that traits like mental deficiency were heritable traits. His observations and research led Goddard to advocate for sterilization and segregation of the intellectually disabled, which were ideas that reflected the emerging eugenics movement in the US, during the early nineteenth century. Although by the end of his life, psychologists largely dismissed Goddard’s work, schools and the US military used Goddard’s version of Binet and Simon’s intelligence test to identify mental deficiency.
Madison Grant was a lawyer and wildlife conservationist who advocated for eugenics policies in the US during the late nineteenth and early twentieth centuries. In his 1916 book, The Passing of the Great Race; or, The Racial Basis of European History, Grant argued that what he called the Nordic race, which originated from northwest Europe, was biologically and culturally superior to all other people, including other Europeans. Grant drew from his now-discredited claims to lobby for laws in the US that restricted immigration, legalized sterilizing people against their will, and prohibited interracial marriage. Adolf Hitler referred to Grant’s book as his Bible and it was listed during the Nuremberg Trials in the late 1940s as evidence that eugenics did not solely originate in Germany. Grant’s advocacy of eugenics shaped policy that restricted reproductive freedom and immigration in the US and helped legitimize genocide in Europe.
Matthew Stanley Meselson conducted DNA and RNA research in the US during the twentieth and twenty-first centuries. He also influenced US policy regarding the use of chemical and biological weapons. Meselson and his colleague Franklin Stahl demonstrated that DNA replication is semi-conservative. Semi-conservative replication means that every newly replicated DNA double helix, which consists of two individual DNA strands wound together, contains one strand that was conserved from a parent double helix and that served as a template for the other strand. Meselson's work enabled researchers to better explain and control cellular development by showing how DNA are copied when a cell divides and interpreted when a cell makes proteins.
George McDonald Church studied DNA from living and from extinct species in the US during the twentieth and twenty-first centuries. Church helped to develop and refine techniques with which to describe the complete sequence of all the DNA nucleotides in an organism's genome, techniques such as multiplex sequencing, polony sequencing, and nanopore sequencing. Church also contributed to the Human Genome Project, and in 2005 he helped start a company, the Personal Genome Project. Church proposed to use DNA from extinct species to clone and breed new organisms from those species.