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James Graves Wilson's six principles of teratology, published in 1959, guide research on teratogenic agents and their effects on developing organisms…
TeratologyAbnormalities, HumanCongenital AbnormalitiesBirth DefectsCongenital DefectsTeratogens are substances that may produce physical or functional defects in the human embryo or fetus after the pregnant woman is exposed to the…
Abnormalities, HumanFetusPregnancyTeratogenicity testingEmbryosEnvironment and Birth Defects by James Graves Wilson in the US was published in 1973. The book summarized information on the causes of malformations…
LiteratureBirth DefectsAbnormalities, HumanTeratogensTeratologyVitamin A (retinol) is an essential vitamin in the daily functioning of human beings that helps regulate cellular differentiation of epithelial…
RetinoidsVitamin A in the bodyTeratogenicity testingAbnormalities, HumanTeratogenic agentsThalidomide is a sedative drug introduced to European markets on 1 October 1957 after extensive testing on rodent embryos to ensure its safety. Early…
ContextTeratogenicity testingAbnormalities, HumanThalidomide--Side effectsThalidomideThe article Experimental Studies on Congenital Malformations was published in the Journal of Chronic Diseases in 1959. The author, James G. Wilson,…
LiteratureAbnormalities, HumanBirth DefectsTeratologymalformationsIsotretinoin is a molecule and a byproduct (metabolite) of vitamin A, and in greater than normal amounts in pregnant women, it can cause fetal…
Teratogenic agentsVitamin AIsotretinoinAbnormalities, HumanTeratogensIsidore Geoffroy Saint-Hilaire studied anatomy and congenital abnormalities in humans and other animals in nineteenth century France. Under the…
TeratologyAnimals--AbnormalitiesAbnormalities, HumanNatural historyAnatomy