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Studies of Thalidomide's Effects on Rodent Embryos from 1962-2008
By: Joanna Yang, Chanapa Tantibanchachai
| Published: Mar 07, 2014
Thalidomide is a sedative drug introduced to European markets on 1 October 1957 after extensive testing on rodent embryos to ensure its safety. Early…
ContextTeratogenicity testingAbnormalities, HumanThalidomide--Side effectsThalidomide
Retinoids As Teratogens
By: Chanapa Tantibanchachai
| Published: Feb 28, 2014
Vitamin A (retinol) is an essential vitamin in the daily functioning of human beings that helps regulate cellular differentiation of epithelial…
RetinoidsVitamin A in the bodyTeratogenicity testingAbnormalities, HumanTeratogenic agents
Isotretinoin (Accutane) as a Teratogen
By: Chanapa Tantibanchachai
| Published: Jul 20, 2014
Isotretinoin is a molecule and a byproduct (metabolite) of vitamin A, and in greater than normal amounts in pregnant women, it can cause fetal…
Teratogenic agentsVitamin AIsotretinoinAbnormalities, HumanTeratogens
Cocaine as a Teratogen
By: Mark Zhang, Chanapa Tantibanchachai
| Published: Oct 17, 2013
Cocaine use by pregnant women has a variety of effects on the embryo and fetus, ranging from various gastro-intestinal and cardiac defects to tissue…
CocaineCocaine abusePregnancyEmbryosFetus
US Regulatory Response to Thalidomide (1950-2000)
By: Chanapa Tantibanchachai
| Published: Apr 01, 2014
Thalidomide, a drug capable of causing fetal abnormalities (teratogen), has caused greater than ten thousand birth defects worldwide since its…
ContextThalidomideThalidomide--Side effectsTeratogenicity testingMultiple Myeloma