Hans Asperger studied mental abnormalities in children in Vienna, Austria, in the early twentieth century. Asperger was one of the early researchers who studied the syndrome that was later named after him, Asperger's Syndrome. Asperger described the syndrome in his 1944 publication Die Autistischen Psychopathen im Kindesalter (Autistic Psychopathy in Childhood). At that time, the syndrome was called autistic psychopathy, and Asperger noted that characteristics of the syndrome included lack of sympathy, one-sided conversations, and difficulty forming friendships. Asperger's work led to the recognition of Asperger's Syndrome as a disorder that results from abnormal development, and the syndrome was later classed on the autism spectrum.

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