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In the early 1960s, John W. Saunders Jr., Mary T. Gasseling, and Lilyan C. Saunders in the US investigated how cells die in the developing limbs of…
Cell DeathChickens--EmbryosApoptosisExperimentsAn important question throughout the history of embryology is whether the formation of a biological structure is predetermined or shaped by its…
Hamburger, Viktor, 1900-2001ExperimentsNervous SystemCell DeathThe review article “Cell Deaths in Normal Vertebrate Ontogeny” (abbreviated as “Cell Deaths”) was published in Biological Reviews of the Cambridge…
LiteratureCell DeathPublicationsVertebratesOntogeny"Apoptosis: A Basic Biological Phenomenon with Wide-Ranging Implications in Tissue Kinetics" (hereafter abbreviated as "Apoptosis") was published in…
LiteratureApoptosisPublicationsCancerCell DeathOnce perceived as an unimportant occurrence in living organisms, cell degeneration was reconfigured as an important biological phenomenon in…
Cell DeathCells--AgingCaenorhabditis elegansAging, CellCellular AgingIn an effort to develop tissue culture techniques for long-term tissue cultivation, French surgeon and biologist Alexis Carrel, and his associates,…
Carrel, Alexis, 1873-1944Tissue cultureCellsGerm CellsEmbryosThe p53 protein acts as a pivotal suppressor of inappropriate cell proliferation. By initiating suppressive effects through induction of apoptosis,…
Tumor Suppressor Protein p53ExperimentsCancerCell Death