Title By Description Created Last modifiedsort descending
ABO Blood Type Identification and Forensic Science (1900-1960) Corey Harbison The use of blood in forensic analysis is a method for identifying individuals suspected of committing some kinds of crimes. Paul Uhlenhuth and Karl Landsteiner, two scientists working separately in Germany in the early twentieth century, showed that there are differences in blood between individuals. Uhlenhuth developed a technique to identify the existence of antibodies, and Landsteiner and his students showed that humans had distinctly different blood types called A, B, AB, and O. 2016-06-02 4 Jul 2018 - 4:40:58am
Interspecies SCNT-derived Humanesque Blastocysts Sarah Taddeo, Jason S. Robert, Nicole Diehnelt Since the 1950s, scientists have developed interspecies blastocysts in laboratory settings, but not until the 1990s did proposals emerge to engineer interspecies blastocysts that contained human genetic or cellular material. Even if these embryos were not permitted to mature to fetal stages, their ethical and political status became debated within nations attempting to use them for research. 2017-06-23 4 Jul 2018 - 4:40:58am
The Formation of Reticular Theory Isra Mishqat In the nineteenth century, reticular theory aimed to describe the properties of neurons, the specialized cells which make up the nervous system, but was later disconfirmed by evidence. Reticular theory stated that the nervous system was composed of a continuous network of specialized cells without gaps (synapses), and was first proposed by researcher Joseph von Gerlach in Germany in 1871. 2017-06-19 4 Jul 2018 - 4:40:58am
The Hedgehog Signaling Pathway in Vertebrates  Dorothy Regan Haskett The hedgehog signaling pathway is a mechanism that regulates cell growth and differentiation during embryonic development, called embryogenesis, in animals. The hedgehog signaling pathway works both between cells and within individual cells. 2016-06-27 4 Jul 2018 - 4:40:58am
Estrogen and the Menstrual Cycle in Humans Brendan Van Iten Estrogen is the primary sex hormone in women and it functions during the reproductive menstrual cycle. Women have three major types of estrogen: estrone, estradiol, and estriol, which bind to and activate receptors within the body. Researchers discovered the three types of estrogen over a period of seven years, contributing to more detailed descriptions of the menstrual cycle. Each type of estrogen molecule contains a slightly different arrangement or number of atoms that in turn causes some of the estrogens to be more active than others. 2016-06-22 4 Jul 2018 - 4:40:58am
The Neuron Doctrine (1860-1895) Isra Mishqat The neuron doctrine is a concept formed during the turn of the twentieth century that describes the properties of neurons, the specialized cells that compose the nervous system. The neuron doctrine was one of two major theories on the composition of the nervous system at the time. Advocates of the neuron doctrine claimed that the nervous system was composed of discrete cellular units. Proponents of the alternative reticular theory, on the other hand, argued that the entire nervous system was a continuous network of cells, without gaps or synapses between the cells. 2017-06-15 4 Jul 2018 - 4:40:59am
Germ Layers Kate MacCord A germ layer is a group of cells in an embryo that interact with each other as the embryo develops and contribute to the formation of all organs and tissues. All animals, except perhaps sponges, form two or three germ layers. The germ layers develop early in embryonic life, through the process of gastrulation. During gastrulation, a hollow cluster of cells called a blastula reorganizes into two primary germ layers: an inner layer, called endoderm, and an outer layer, called ectoderm. 2013-09-17 4 Jul 2018 - 4:40:59am
"The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme" (1979), by Stephen J. Gould and Richard C. Lewontin M. Elizabeth Barnes The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme, hereafter called The Spandrels, is an article written by Stephen J. Gould and Richard C. Lewontin published in the Proceedings of the Royal Society of London in 1979. The paper emphasizes issues with what the two authors call adaptationism or the adaptationist programme as a framework to explain how species and traits evolved. The paper is one in a series of works in which Gould emphasized the 2014-11-14 4 Jul 2018 - 4:40:59am
Ovism Cera R. Lawrence Ovism was one of two models of preformationism, a theory of generation prevalent in the late seventeenth through the end of the eighteenth century. Contrary to the competing theory of epigenesis (gradual emergence of form), preformationism held that the unborn offspring existed fully formed in the eggs or sperm of its parents prior to conception. The ovist model held that the maternal egg was the location of this preformed embryo, while the other preformationism model known as spermism preferred the paternal germ cell, as the name implies. 2008-08-13 4 Jul 2018 - 4:40:59am
George W. Beadle's One Gene-One Enzyme Hypothesis Divyash Chhetri The one gene-one enzyme hypothesis, proposed by George Wells Beadle in the US in 1941, is the theory that each gene directly produces a single enzyme, which consequently affects an individual step in a metabolic pathway. In 1941, Beadle demonstrated that one gene in a fruit fly controlled a single, specific chemical reaction in the fruit fly, which one enzyme controlled. 2014-05-23 4 Jul 2018 - 4:40:59am
Beadle's One Gene-One Enzyme Hypothesis Amy Pribadi Between 1934 and 1945, George Beadle developed a hypothesis that each gene within the chromosomes of organisms each produced one enzyme. Enzymes are types of proteins that can catalyze reactions inside cells, and the figure shows that each enzyme controls a stage in a series of biochemical reactions. The top box in this figure represents a normal process of enzyme production and biochemical reactions, and the bottom box shows how Beadle's experiments affected the normal biochemical process. 2016-10-12 4 Jul 2018 - 4:40:59am
The Source-Sink Model Jack Resnik The source-sink model, first proposed by biologist Francis Crick in 1970, is a theoretical system for how morphogens distribute themselves across small fields of early embryonic cells. A morphogen is a substance that determines the fate and phenotype of a group of cells through a concentration gradient of itself across that group. Crick’s theory has been experimentally confirmed with several morphogens, most notably with the protein bicoid , the first discovered morphogen. The model provides a theoretical structure for the understanding of some features of early embryonic development. 2012-05-07 4 Jul 2018 - 4:40:59am
The Blastoderm in Chicks During Early Gastrulation Chinami Michaels This image shows a chicken (Gallus gallus) embryo undergoing gastrulation in stage four (18-19 hrs after laying) according to the Hamburger-Hamilton staging series. At this point in time the chicken embryo is a blastoderm (shown in blue). The first magnification of the embryo shows that the blastoderm cell layers have thickened to form the primitive streak and Hensen's node. The primitive streak extends from the posterior (P) region to the anterior (A) region. The second rectangular magnification shows the blastoderm cross-sectioned through the primitive streak. 2014-02-26 4 Jul 2018 - 4:40:59am
Molecular Epigenetics and Development: Histone Conformations, DNA Methylation and Genomic Imprinting Tristan Cooper-Roth Introduced by Conrad Hal Waddington in 1942, the concept of epigenetics gave scientists a new paradigm of thought concerning embryonic development, and since then has been widely applied, for instance to inheritable diseases, molecular technologies, and indeed the human genome as a whole. A genome contains an embedded intricate coding template that provides a means of genetic expression from the initial steps of embryonic development until the death of the organism. Within the genome there are two prominent components: coding (exons) and non-coding (introns) sequences. 2010-09-28 4 Jul 2018 - 4:40:59am
Karl Ernst von Baer's Laws of Embryology M. Elizabeth Barnes In 1828, while working at the University of Konigsberg in Konigsberg, Germany Karl Ernst von Baer proposed four laws of animal development, which came to be called von Baer's laws of embryology. With these laws, von Baer described the development (ontogeny) of animal embryos while also critiquing popular theories of animal development at the time. 2014-04-15 4 Jul 2018 - 4:40:59am
Human Papillomavirus (HPV) Strains 16 and 18 Grace Kim The Human Papillomavirus (HPV) strains 16 and 18 are the two most common HPV strains that lead to cases of genital cancer. HPV is the most commonly sexually transmitted disease, resulting in more than fourteen million cases per year in the United States alone. When left untreated, HPV leads to high risks of cervical, vaginal, vulvar, anal, and penile cancers. In 1983 and 1984 in Germany, physician Harald zur Hausen found that two HPV strains, HPV-16 and HPV-18, caused cervical cancer in women. In the early twenty first century, pharmaceutical companies Merck & Co. 2017-05-04 4 Jul 2018 - 4:40:59am
The Role of the Notch signaling pathway in Somitogenesis Justin M. Wolter Among other functions, the Notch signaling pathway contributes to the development of somites in animals. It involves a cell signaling mechanism with a wide range of functions, including cellular differentiation, and the formation of the embryonic structures (embryogenesis). All multicellular animals use Notch signaling, which is involved in the development, maintenance, and regeneration of a range of tissues. The Notch signaling pathways spans two cells, and consists of receptor proteins, which cross one cell's membrane and interacts with proteins on adjacent cells, called ligands. 2014-03-23 4 Jul 2018 - 4:40:59am
Telomerase in Human Development Zane Bartlett Telomerase is an enzyme that regulates the lengths of telomeres in the cells of many organisms, and in humans it begins to function int the early stages of embryonic development. Telomeres are repetitive sequences of DNA on the ends of chromosomes that protect chromosomes from sticking to each other or tangling. In 1989, Gregg Morin found that telomerase was present in human cells. In 1996, Woodring Wright and his team examined human embryonic cells and found that telomerase was active in them. Scientists manipulate telomerase in cells to give cells the capacity to replicate infinitely. 2015-03-23 4 Jul 2018 - 4:40:59am
Wilhelm Johannsen's Genotype-Phenotype Distinction B. R. Erick Peirson Wilhelm Johannsen in Denmark first proposed the distinction between genotype and phenotype in the study of heredity in 1909. This distinction is between the hereditary dispositions of organisms (their genotypes) and the ways in which those dispositions manifest themselves in the physical characteristics of those organisms (their phenotypes). This distinction was an outgrowth of Johannsen's experiments concerning heritable variation in plants, and it influenced his pure line theory of heredity. 2012-12-07 4 Jul 2018 - 4:40:59am
"Mitochondrial DNA and Human Evolution" (1987), by Rebecca Louise Cann, Mark Stoneking, and Allan Charles Wilson Dorothy R. Haskett In 1987 Rebecca Louise Cann, Mark Stoneking, and Allan Charles Wilson published Mitochondrial DNA and Human Evolution in the journal Nature. The authors compared mitochondrial DNA from different human populations worldwide, and from those comparisons they argued that all human populations had a common ancestor in Africa around 200,000 years ago. Mitochondria DNA (mtDNA) is a small circular genome found in the subcellular organelles, called mitochondria. 2014-10-10 4 Jul 2018 - 4:40:59am
Mechanism of Notch Signaling Cheryl Lancaster Mechanism of Notch Signaling: The image depicts a type of cell signaling, in which two animal cells interact and transmit a molecular signal from one to the other. The process results in the production of proteins, which influence the cells as they differentiate, move, and contribute to embryological development. In the membrane of the signaling cell, there is a ligand (represented by a green oval). The ligand functions to activate a change in a receptor molecule. In the receiving cell, there are receptors; in this case, Notch proteins (represented by orange forks). 2014-08-21 4 Jul 2018 - 4:40:59am
The French Flag Model Jack Resnik The French flag model represents how embryonic cells receive and respond to genetic information and subsequently differentiate into patterns. Created by Lewis Wolpert in the late 1960s, the model uses the French tricolor flag as visual representation to explain how embryonic cells can interpret genetic code to create the same pattern even when certain pieces of the embryo are removed. Wolpert's model has provided crucial theoretical framework for investigating universal mechanisms of pattern formation during development. 2011-05-19 4 Jul 2018 - 4:40:59am
DNA and X and Y Chromosomes Anna Guerrero Y-chromosomes exist in the body cells of many kinds of male animals. Found in the nucleus of most living animal cells, the X and Y-chromosomes are condensed structures made of DNA wrapped around proteins called histones. The individual histones bunch into groups that the coiled DNA wraps around called a nucleosome, which are roughly 10 nano-meters (nm) across. The histones bunch together to form a helical fiber (30 nm) that spins into a supercoil (200 nm). During much of a cell's life, DNA exists in the 200 nm supercoil phase. 2017-02-06 4 Jul 2018 - 4:40:59am
Translational Developmental Biology Mary E. Sunderland Translational developmental biology is a growing approach to studying biological phenomena that explicitly aims to develop medical therapies. When discussing the generation of new therapies it is often argued that they will emerge as a "translation" from "fundamental biology." Although translational research is not a new term, "translational developmental biology" has been steadily gaining popularity as discoveries in cell and developmental biology, particularly those involving stem cells, provide a basis for regenerative medicine. 2009-06-10 4 Jul 2018 - 4:40:59am
Endothelium Kate MacCord The endothelium is the layer of cells lining the blood vessels in animals. It weighs more than one kilogram in adult humans, and it covers a surface area of 4000 to 7000 square meters. The endothelium is the cellular interface between the circulating blood and underlying tissue. As the medium between these two sets of tissues, endothelium is part of many normal and disease processes throughout the body. 2014-01-28 4 Jul 2018 - 4:40:59am
Twilight Sleep Jessica Pollesche Twilight Sleep (Dammerschlaf) was a form of childbirth first used in the early twentieth century in Germany in which drugs caused women in labor to enter a state of sleep prior to giving birth and awake from childbirth with no recollection of the procedure. Prior to the early twentieth century, childbirth was performed at home and women did not have anesthetics to alleviate the pain of childbirth. In 1906, obstetricians Bernhardt Kronig and Karl Gauss developed the twilight sleep method in 1906 to relieve the pain of 2018-05-16 4 Jul 2018 - 4:40:59am
Hermaphrodites and the Medical Invention of Sex (1998), by Alice Domurat Dreger Mary Drago Hermaphrodites and the Medical Invention of Sex, by historian of science Alice Domurat Dreger, was published in 1998 by Harvard University Press. In the book, Dreger describes how many doctors and scientists treated human hermaphrodites from the late nineteenth century to the early twentieth century. She states that during this time period, many physicians and scientists struggled to determine the nature sex, and to support a classification of sex as male or female, many physicians and scientists resorted to viewing a person's gonads for identification of his or her sex. 2014-04-09 4 Jul 2018 - 4:40:59am
Human Papillomavirus (HPV) Strains 16 and 18 Grace Kim The Human Papillomavirus (HPV) strains 16 and 18 are the two most common HPV strains that lead to cases of genital cancer. HPV is the most commonly sexually transmitted disease, resulting in more than fourteen million cases per year in the United States alone. When left untreated, HPV leads to high risks of cervical, vaginal, vulvar, anal, and penile cancers. In 1983 and 1984 in Germany, physician Harald zur Hausen found that two HPV strains, HPV-16 and HPV-18, caused cervical cancer in women. In the early twenty first century, pharmaceutical companies Merck & Co. 2017-07-19 4 Jul 2018 - 4:40:59am
Fetus in Fetu Corinne DeRuiter Fetus in fetu is a rare variety of parasitic twins , where the developmentally abnormal parasitic twin is completely encapsulated within the torso of the otherwise normally developed host twin. In the late eighteenth century, German anatomist Johann Friedrich Meckel was the first to described fetus in fetu, which translates to “fetus within fetus.” Fetus in fetu is thought to result from the unequal division of the totipotent inner cell mass , the mass of cells that is the ancestral precursor to all cells in the body. 2012-05-30 4 Jul 2018 - 4:40:59am
Mitochondrial DNA (mtDNA) Dorothy R. Haskett Mitochondrial DNA (mtDNA) is located outside the nucleus in the liquid portion of the cell (cytoplasm) inside cellular organelles called Mitochondria. Mitochondria are located in all complex or eukaryotic cells, including plant, animal, fungi, and single celled protists, which contain their own mtDNA genome. In animals with a backbone, or vertebrates, mtDNA is a double stranded, circular molecule that forms a circular genome, which ranges in size from sixteen to eighteen kilo-base pairs, depending on species. Each mitochondrion in a cell can have multiple copies of the mtDNA genome. 2014-12-19 4 Jul 2018 - 4:40:59am
Hartsoeker's Homunculus Sketch from Essai de Dioptrique Cera R. Lawrence This embryology image is a pencil sketch by Nicolaas Hartsoeker, published as part of his 1694 French-language paper entitled Essai de Dioptrique, a semi-speculative work describing the sorts of new scientific observations that could be done using magnifying lenses. Dioptrique was published in Paris by the publishing house of Jean Anisson. The image depicts a curled up infant-like human, now referred to as a homunculus, inside the head of a sperm cell. 2008-08-14 4 Jul 2018 - 4:40:59am
Purkinje Cells Mandana Minai Purkinje cells, also called Purkinje neurons, are neurons in vertebrate animals located in the cerebellar cortex of the brain. Purkinje cell bodies are shaped like a flask and have many threadlike extensions called dendrites, which receive impulses from other neurons called granule cells. Each cell also has a single projection called an axon, which transmits impulses to the part of the brain that controls movement, the cerebellum. Purkinje cells are inhibitory neurons: they secrete neurotransmitters that bind to receptors that inhibit or reduce the firing of other neurons. 2014-08-12 4 Jul 2018 - 4:40:59am
Fruit Fly Life Cycle Amy Pribadi Fruit flies of the species Drosophila melanogaster develop from eggs to adults in eight to ten days at 25 degrees Celsius. They develop through four primary stages: egg, larva, pupa, and adult. When in the wild, female flies lay their fertilized eggs in rotting fruit or other decomposing material that can serve as food for the larvae. In the lab, fruit flies lay their fertilized eggs in a mixture of agar, molasses, cornmeal, and yeast. After roughly a day, each egg hatches into a larva. 2016-10-11 4 Jul 2018 - 4:40:59am
Epigenetic Landscape Adam R. Navis The epigenetic landscape is a concept representing embryonic development. It was proposed by Conrad Hal Waddington to illustrate the various developmental pathways a cell might take toward differentiation. The epigenetic landscape integrates the connected concepts of competence, induction, and regulative abilities of the genes into a single model designed to explain cellular differentiation, a long standing problem in embryology. 2007-10-30 4 Jul 2018 - 4:40:59am
Estrogen Brendan Van Iten The figure depicts three different molecular structures of estrogen found in mammals’ that differ by the arrangement of bonds and side groups. The molecular structures of the three estrogen molecules differ by the arrangement of chemical bonds and side groups attached to the core steroid structure, cholesterol, which contains three cyclohexane rings and one cyclopentane ring. 2017-05-18 4 Jul 2018 - 4:40:59am
"Evolution and Tinkering" (1977), by Francois Jacob Valerie Racine In his essay Evolution and Tinkering, published in Science in 1977, Francois Jacob argued that a common analogy between the process of evolution by natural selection and the methods of engineering is problematic. Instead, he proposed to describe the process of evolution with the concept of bricolage (tinkering). In this essay, Jacob did not deny the importance of the mechanism of natural selection in shaping complex adaptations. Instead, he maintained that the cumulative effects of 2014-10-24 4 Jul 2018 - 4:40:59am
"Testing the Kin Selection Theory: Who Controls the Investments?" from The Ants (1990), by Bert Hölldobler and Edward O. Wilson Kelle Dhein In “Testing the Kin Selection Theory: Who Controls the Investments?” Bert Hölldobler and Edward Osborne Wilson discussed the predictive power of kin selection theory, a theory about the evolution of social behaviors. As part of Hölldobler's and Wilson's 1990 book titled The Ants, Hölldobler and Wilson compared predictions about the reproductive practices of ants to data about the reproductive practices of ants. They showed that the data generally supported the expected behaviors proposed by kin selection theory. 2017-04-18 4 Jul 2018 - 4:40:59am
Mitochondria Dorothy R. Haskett All cells that have a nucleus, including plant, animal, fungal cells, and most single-celled protists, also have mitochondria. Mitochondria are particles called organelles found outside the nucleus in a cell's cytoplasm. The main function of mitochondria is to supply energy to the cell, and therefore to the organism. The theory for how mitochondria evolved, proposed by Lynn Margulis in the twentieth century, is that they were once free-living organisms. 2014-07-05 4 Jul 2018 - 4:40:59am
The Y-Chromosome in Animals Dorothy R. Haskett The Y-chromosome is one of a pair of chromosomes that determine the genetic sex of individuals in mammals, some insects, and some plants. In the nineteenth and twentieth centuries, the development of new microscopic and molecular techniques, including DNA sequencing, enabled scientists to confirm the hypothesis that chromosomes determine the sex of developing organisms. In an adult organism, the genes on the Y-chromosome help produce the male gamete, the sperm cell. Beginning in the 1980s, many studies of human populations used the Y-chromosome gene sequences to trace paternal lineages. 2015-05-28 4 Jul 2018 - 4:40:59am
Julia Barlow Platt's Embryological Observations on Salamanders' Cartilage (1893) Karina Ramirez In 1893, Julia Barlow Platt published her research on the origins of cartilage in the developing head of the common mudpuppy (Necturus maculosus) embryo. The mudpuppy is an aquatic salamander commonly used by embryologists because its large embryonic cells and nuclei are easy to see. Platt followed the paths of cells in developing mudpuppy embryos to see how embryonic cells migrated during the formation of the head. With her research, Platt challenged then current theories about germ layers, the types of cells in an early embryo that develop into adult cells. 2017-03-06 4 Jul 2018 - 4:40:59am
Charles Darwin's Theory of Pangenesis Yawen Zou In 1868 in England, Charles Darwin proposed his pangenesis theory to describe the units of inheritance between parents and offspring and the processes by which those units control development in offspring. Darwin coined the concept of gemmules, which he said referred to hypothesized minute particles of inheritance thrown off by all cells of the body. The theory suggested that an organism's environment could modify the gemmules in any parts of the body, and that these modified gemmules would congregate in the reproductive organs of parents to be passed on to their offspring. 2014-07-20 4 Jul 2018 - 4:40:59am
The Hayflick Limit Zane Bartlett The Hayflick Limit is a concept that helps to explain the mechanisms behind cellular aging. The concept states that a normal human cell can only replicate and divide forty to sixty times before it cannot divide anymore, and will break down by programmed cell death or apoptosis. The concept of the Hayflick Limit revised Alexis Carrel's earlier theory, which stated that cells can replicate themselves infinitely. Leonard Hayflick developed the concept while at the Wistar Institute in Philadelphia, 2014-11-14 4 Jul 2018 - 4:40:59am
The Development of the Neural Crest and the Migration of Neural Crest Cells (NCCs) in the Embryos of Various Vertebrates Brian K. Hall, M. Elizabeth Barnes This diagram shows how NCCs migrate differently in rats, birds and amphibians. The arrows represent both chronology of NCCs migration and the differential paths that NCCs follow in different classes of animals. The solid black portion of each illustration represents the neural crest, and the large black dots in (c) and in (f) represent the neural crest cells. The speckled sections that at first form a basin in (a) and then close to form a tube in (f) represent the neural ectoderm. The solid white portions represent the epidermal ectoderm. 2014-08-21 4 Jul 2018 - 4:40:59am
Spermism Cera R. Lawrence Spermism was one of two models of preformationism, a theory of embryo generation prevalent in the late seventeenth through the end of the eighteenth century. Spermist preformationism was the belief that offspring develop from a tiny fully-formed fetus contained within the head of a sperm cell. This model developed slightly later than the opposing ovist model because sperm cells were not seen under the microscope until about 1677. 2008-08-13 4 Jul 2018 - 4:40:59am
The Discovery of The Dikika Baby Fossil as Evidence for Australopithecine Growth and Development Paige Madison When scientists discovered a 3.3 million-year-old skeleton of a child of the human lineage (hominin) in 2000, in the village of Hadar, Ethiopia, they were able to study growth and development of Australopithecus afarensis, an extinct hominin species. The team of researchers, led by Zeresenay Alemseged of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, named the fossil DIK 1-1 and nicknamed it Dikika baby after the Dikika research site. The Dikika fossil 2015-02-02 4 Jul 2018 - 4:40:59am
Chloroplasts Anna Guerrero Chloroplasts are the organelles in plant and algal cells that conduct photosynthesis. A single chloroplast has an outer membrane and an inner membrane, with an intermembrane space in between. Within the inner membrane, interconnected stacks of thylakoids, called granum, float in a protein rich fluid called the stroma. These thylakoid stacks contain chlorophyll, a pigment which converts sunlight into usable energy for plants and free oxygen from water. The stacks are sites of light reactions within a plant cell. 2017-02-06 4 Jul 2018 - 4:40:59am
Reassessment of Carrel's Immortal Tissue Culture Experiments Lijing Jiang In the 1910s, Alexis Carrel, a French surgeon and biologist, concluded that cells are intrinsically immortal. His claim was based on chick-heart tissue cultures in his laboratory that seemed to be able to proliferate forever. Carrel's ideas about cellular immortality convinced his many contemporaries that cells could be maintained indefinitely. In the 1960s, however, Carrel's thesis about cell immortality was put into question by the discovery that human diploid cells can only proliferate for a finite period. 2010-06-28 4 Jul 2018 - 4:40:59am
Beadle and Tatum's 1941 Experiments with Neurospora Revealed that Genes Produce Enzymes Amy Pribadi This illustration shows George Beadle and Edward Tatum's experiments with Neurospora crassa that indicated that single genes produce single enzymes. The pair conducted the experiments at Stanford University in Palo Alto, California. Enzymes are types of proteins that can catalyze reactions inside cells, reactions that produce a number of things, including nutrients that the cell needs. Neurospora crassa is a species of mold that grows on bread. 2016-10-12 4 Jul 2018 - 4:40:59am
Richard Woltereck's Concept of Reaktionsnorm B. R. Erick Peirson Richard Woltereck first described the concept of Reaktionsnorm (norm of reaction) in his 1909 paper 'Weitere experimentelle Untersuchungen uber Art-veranderung, speziell uber das Wesen quantitativer Artunterschiede bei Daphniden' ('Further investigations of type variation, specifically concerning the nature of quantitative differences between varieties of Daphnia'). This concept refers to the ways in which the environment can alter the development of an organism, and its adult characteristics. 2012-09-06 4 Jul 2018 - 4:40:59am
Neurocristopathies M. Elizabeth Barnes Neurocristopathies are a class of pathologies in vertebrates, including humans, that result from abnormal expression, migration, differentiation, or death of neural crest cells (NCCs) during embryonic development. NCCs are cells derived from the embryonic cellular structure called the neural crest. Abnormal NCCs can cause a neurocristopathy by chemically affecting the development of the non-NCC tissues around them. They can also affect the development of NCC tissues, causing defective migration or 2014-09-19 4 Jul 2018 - 4:40:59am