Title By Description Created Last modifiedsort ascending
Roger Sperry’s Split Brain Experiments (1959–1968) Dina A. Lienhard In the 1950s and 1960s, Roger Sperry performed experiments on cats, monkeys, and humans to study functional differences between the two hemispheres of the brain in the United States. To do so he studied the corpus callosum, which is a large bundle of neurons that connects the two hemispheres of the brain. Sperry severed the corpus callosum in cats and monkeys to study the function of each side of the brain. He found that if hemispheres were not connected, they functioned independently of one another, which he called a split-brain. 2017-12-27 30 Nov 2018 - 5:02:26am
David H. Hubel and Torsten N. Wiesel’s Research on Optical Development in Kittens Dina A. Lienhard During 1964, David Hubel and Torsten Wiesel studied the short and long term effects of depriving kittens of vision in one eye. In their experiments, Wiesel and Hubel used kittens as models for human children. Hubel and Wiesel researched whether the impairment of vision in one eye could be repaired or not and whether such impairments would impact vision later on in life. The researchers sewed one eye of a kitten shut for varying periods of time. 2017-10-11 30 Nov 2018 - 5:02:02am
Jennifer Doudna and Emmanuelle Charpentier’s Experiment About the CRISPR/cas 9 System’s Role in Adaptive Bacterial Immunity (2012) Meilin Zhu In 2012, Jennifer Doudna, Emmanuelle Charpentier from the University of California, Berkeley, in Berkeley, California, and Umeå University in Umeå, Sweden, along with their colleagues discovered how bacteria use the CRISPR/cas 9 system to protect themselves from viruses. The researchers also proposed the idea of using the CRISPR/cas 9 system as a genome editing tool. 2017-10-19 30 Nov 2018 - 4:58:19am
"Transplantation of Living Nuclei from Blastula Cells into Enucleated Frogs' Eggs" (1952), by Robert Briggs and Thomas J. King Nicole Newkirk In 1952 Robert Briggs and Thomas J. King published their article, "Transplantation of Living Nuclei from Blastula Cells into Enucleated Frogs' Eggs," in the Proceedings of the National Academy of Sciences, the culmination of a series of experiments conducted at the Institute for Cancer Research and Lankenau Hospital Research Institute in Philadelphia, Pennsylvania. In this paper Briggs and King examined whether nuclei of embryonic cells are differentiated, and by doing so, were the first to conduct a successful nuclear transplantation with amphibian embryos. 2007-11-13 4 Jul 2018 - 4:40:59am
"The Association between Depressive Symptoms and Social Support in Taiwanese Women During the Month" (2004), by Shu-Shya Heh et al. Cecilia Chou In 2004, Shu-Shya Heh, Lindsey Coombes, and Helen Bartlett studied the association between Chinese postpartum (post-childbirth) practices and postpartum depression in Taiwanese women. The researchers surveyed Taiwanese women about the social support they received after giving birth and then evaluated the depression rates in the same women. Heh and her colleagues focused on the month following childbirth, which according to traditional Chinese medicine, is an important period that warrants a set of specialized practices to aid the woman's recovery. 2017-04-11 4 Jul 2018 - 4:40:59am
"Experiments on Artificial Parthenogenesis in Annelids (Chaetopterus) and the Nature of the Process of Fertilization" (1901), by Jacques Loeb Steve Elliott Jacques Loeb showed that scientists could achieve artificial parthenogenesis with some types of annelid worm eggs through a series of experiments in 1900. Loeb published the results of his experiments in 1901 as "Experiments on Artificial Parthenogenesis in Annelids (Chaetopterus) and the Nature of the Process of Fertilization," in The American Journal of Physiology. Loeb 's results broadened the range of animals to which artificial parthenogenesis applied beyond sea urchins. 2009-06-10 4 Jul 2018 - 4:40:59am
"On the Induction of Embryonic Primordia by Implantation of Organizers from Different Species" (1924), Hilde Mangold's Dissertation Megan Kearl, Kate MacCord Hilde Proscholdt Mangold was a doctoral student at the Zoological Institute at the University of Freiburg in Freiburg, Germany, from 1920-1923. Mangold conducted research for her dissertation 'On the Induction of Embryonic Primordia by Implantation of Organizers from Different Species' ('Ueber Induktion von Embryonanlagen durch Implantation artfremder Organisatoren'), under the guidance of Hans Spemann, a professor of zoology at the University of Freiburg. 2012-12-19 4 Jul 2018 - 4:40:59am
"The Familial Factor in Toxemia of Pregnancy" (1968), by Leon C. Chesley, et al. Sarah Patel In the 1950s and 1960s, researchers Leon Chesley, John Annitto, and Robert Cosgrove investigated the possible familial factor for the conditions of preeclampsia and eclampsia in pregnant women. Preeclampsia and eclampsia, which are related to high blood pressure, have unknown causes and affect at least five percent of all pregnancies. 2017-03-16 4 Jul 2018 - 4:40:59am
A plant genetically modified that accumulates Pb is especially promising for phytoremediation (2003), by Carmina Gisbert et al. Ernest Nkansah-Dwamena In 2003, Carmina Gisbert and her research team produced a tobacco plant that could remove lead from soil. To do so, they inserted a gene from wheat plants that produces phytochelatin synthase into a shrub tobacco plant (Nicotiana glauca) to increase N. glauca's absorption and tolerance of toxic metals, particularly lead and cadmium. Gisbert and her team aimed to genetically modify a plant so that it could be used for phytoremediation- using plants to remove toxic substances from the soil. 2014-12-30 4 Jul 2018 - 4:40:59am
Robert Geoffrey Edwards and Patrick Christopher Steptoe's Clinical Research in Human in vitro Fertilization and Embryo Transfer, 1969-1980 Lijing Jiang The biomedical accomplishment of human in vitro fertilization and embryo transfer (IVF-ET) took years to become the successful technique that presently enables infertile couples to have their own children. In 1969, more than ten years after the first attempts to treat infertilities with IVF technologies, the British developmental biologist Robert Geoffrey Edwards fertilized human oocytes in a Petri dish for the first time. 2011-05-12 4 Jul 2018 - 4:40:59am
"Interspecific Chimeras in Mammals: Successful Production of Live Chimeras Between Mus musculus and Mus caroli" (1980), by Janet Rossant and William I. Frels Nicole Newkirk In 1980 Janet Rossant and William I. Frels published their paper, "Interspecific Chimeras in Mammals: Successful Production of Live Chimeras Between Mus musculus and Mus caroli," in Science. Their experiment involved the first successful creation of interspecific mammalian chimeras. Mammalian chimeras are valuable for studying early embryonic development. However, in earlier studies, clonal analysis was restricted by the lack of a cell marker, present at all times, that makes a distinction between the two parental cell types in situ. 2007-10-30 4 Jul 2018 - 4:40:59am
Sonja Vernes, et al.'s Experiments On the Gene Networks Affected by the Foxp2 Protein (2011) Kat Fowler In 2011, Sonja Vernes and Simon Fisher performed a series of experiments to determine which developmental processes are controlled by the mouse protein Foxp2. Previous research showed that altering the Foxp2 protein changed how neurons grew, so Vernes and Fisher hypothesized that Foxp2 would affect gene networks that involved in the development of neurons, or nerve cells. Their results confirmed that Foxp2 affected the development of gene networks involved in the growth of neurons, as well as networks that are involved in cell specialization and cell communication. 2017-05-30 4 Jul 2018 - 4:40:59am
"Cellular death in morphogenesis of the avian wing" (1962), by John W. Saunders Jr., et al. Lijing Jiang In the early 1960s, John W. Saunders Jr., Mary T. Gasseling, and Lilyan C. Saunders in the US investigated how cells die in the developing limbs of chick embryos. They studied when and where in developing limbs many cells die, and they studied the functions of cell death in wing development. At a time when only a few developmental biologists studied cell death, or apoptosis, Saunders and his colleagues showed that researchers could use embryological experiments to uncover the causal mechanisms of apotosis. 2014-03-07 4 Jul 2018 - 4:40:59am
Ponseti's Treatment for Congenital Clubfoot (1963) Katherine Gandee In 1963, Ignacio Ponseti and Eugene Smoley experimentally determined an effective and minimally invasive method of treating congenital clubfoot. Congenital clubfoot is a disorder in which a newborn’s foot is rigidly turned inwards and upwards. During the early 1960s, orthopedists often relied on invasive surgical procedures to treat clubfoot. 2017-12-27 4 Jul 2018 - 4:40:59am
"The Potency of the First Two Cleavage Cells in Echinoderm Development. Experimental Production of Partial and Double Formations" (1891-1892), by Hans Driesch Megan Kearl Hans Adolf Eduard Driesch was a late-nineteenth and early-twentieth century philosopher and developmental biologist. In the spring of 1891 Driesch performed experiments using two-celled sea urchin embryos, the results of which challenged the then-accepted understanding of embryo development. Driesch showed that the cells of an early embryo, when separated, could each continue to develop into normal larval forms. 2012-01-01 4 Jul 2018 - 4:40:59am
Amphioxus, and the Mosaic Theory of Development (1893), by Edmund Beecher Wilson James Lowe Edmund Beecher Wilson experimented with Amphioxus (Branchiostoma) embryos in 1892 to identify what caused their cells to differentiate into new types of cells during the process of development. Wilson shook apart the cells at early stages of embryonic development, and he observed the development of the isolated cells. He observed that in the normal development of Amphioxus, all three main types of symmetry, or cleavage patterns observed in embryos, could be found. Wilson proposed a hypothesis that reformed the Mosaic Theory associated with Wilhelm Roux in Germany. 2015-03-31 4 Jul 2018 - 4:40:59am
Management of Myelomeningocele Study Clinical Trial (2003–2010) Jessica Pollesche From February 2003 to December 2010, researchers of the Management of Myelomeningocele Study, or MOMS, clinical trial compared the safety and efficacy of different treatments for a specific type of spina bifida, called myelomeningocele. Myelomeningocele, the most frequent and severe form of spina bifida, is a condition in which the bony spinal column does not develop correctly, which causes an opening of the spine, exposure of the spinal cord, and formation of a small sac containing cerebrospinal fluid. 2017-11-15 4 Jul 2018 - 4:40:59am
"Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants" (2010), by Scott Sicherer, et al. Maggie Pingolt In 2010, a team of US researchers concluded that the more peanuts a pregnant woman ate during her pregnancy, the more likely her newborn was to be sensitive to peanuts. They published their results in 2010's "Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants." The work resulted from the collaboration of Scott Sicherer and Hugh Sampson, both from the Jaffe Food Allergy Institute, Mount Sinai School of Medicine, in New York, New York along with other colleagues. 2013-01-30 4 Jul 2018 - 4:40:59am
Treatment of Anemia during Pregnancy (1931), by Lucy Wills Lauren Lynch In 1931, physician Lucy Wills conducted a study of nutritional deficiencies that caused anemia in pregnant women in Bombay, India, later renamed Mumbai. Anemia is a lack of healthy red blood cells in the blood. Wills published the results of her study in the medical article 'Treatment of ‘Pernicious Anaemia of Pregnancy' and 'Tropical Anaemia'' in the British Medical Journal in 1931. Wills's research contributed to knowledge of anemia and the possible causes associated with the disease, such as the symptoms of fatigue and irritability. 2017-04-20 4 Jul 2018 - 4:40:59am
"How do Embryos Assess Risk? Vibrational Cues in Predator-Induced Hatching of Red-Eyed Treefrogs" (2005), by Karen Warkentin Karla T. Moeller In 'How do Embryos Assess Risk? Vibrational Cues in Predator-Induced Hatching of Red-Eyed Treefrogs' (2005), Karen Warkentin reported on experiments she conducted to see how red-eyed treefrog embryos, Agalychnis callidryas, can distinguish between vibrations due to predator attacks and other environmental occurrences, such as storms. Though the ability of red-eyed treefrogs to alter their hatch timing had been documented, the specific cues that induce early hatching were not well understood. 2012-04-07 4 Jul 2018 - 4:40:59am
The inductive capacity of oral mesenchyme and its role in tooth development (1969-1970), by Edward J. Kollar and Grace R. Baird Kate MacCord Between February 1969 and August 1970 Edward Kollar and Grace Baird, from the University of Chicago in Chicago, Illinois, published three papers that established the role of the mesenchyme in tooth induction. Drawing upon a history of using tissue interactions to understand differentiation, Kollar and Baird designed their experiments to understand how differentiated structures become specified. Their work overturned a widely accepted model that epithelium controls the identity of the structure, a phenomenon called structural specificity. 2013-03-15 4 Jul 2018 - 4:40:59am
"Congenital Club Foot in the Human Fetus" (1980), by Ernesto Ippolito and Ignacio Ponseti Katherine Gandee In 1980, Ernesto Ippolito and Ignacio Ponseti published their results on a histological study they performed on congenital club foot in human fetuses. The researchers examined the feet of four aborted fetuses and compared the skeletal tissues from healthy feet to those affected by congenital club foot. Infants born with club foot are born with one or both feet rigidly twisted inwards and upwards, making typical movement painful and challenging. 2017-03-16 4 Jul 2018 - 4:40:59am
Digit Regeneration Is Regulated by Msx1 and BMP4 in Fetal Mice (2003), by Manjong Han et al. Joe Brinkman In the early 2000s, Manjong Han, Xiaodang Yang, Jennifer Farrington, and Ken Muneoka investigated how genes and proteins in fetal mice (Mus musculus) influenced those fetal mice to regenerate severed toes at Tulane University in New Orleans, Louisiana. The group used hind limbs from mice to show how the gene Msx1 (Homeobox 7) functions in regenerating amputated digits. 2015-04-13 4 Jul 2018 - 4:40:59am
"Embryonic Stem Cell Lines Derived from Human Blastocytes" (1998), by James Thomson Ke Wu After becoming chief pathologist at the University of Wisconsin-Madison Wisconsin Regional Primate Center in 1995, James A. Thomson began his pioneering work in deriving embryonic stem cells from isolated embryos. That same year, Thomson published his first paper, "Isolation of a Primate Embryonic Stem Cell Line," in Proceedings of the National Academy of Sciences of the United States of America, detailing the first derivation of primate embryonic stem cells. In the following years, Thomson and his team of scientists - Joseph Itskovitz-Eldor, Sander S. Shapiro, Michelle A. 2011-02-01 4 Jul 2018 - 4:40:59am
"Purification of a Nerve-Growth Promoting Protein from the Mouse Salivary Gland and its Neuro-Cytoxic Antiserum" (1960), by Stanley Cohen Adam R. Navis Stanley Cohen published "Purification of a Nerve-Growth Promoting Protein from the Mouse Salivary Gland and its Neuro-Cytoxic Antiserum" in the Proceedings of the National Academies of Sciences in 1960. This paper outlined the successful purification and identification of nerve growth factor (NGF) as a protein, the developmental effects of depriving an embryo of NGF, and the discovery that NGF is also required for the maintenance of the nervous system. 2007-10-30 4 Jul 2018 - 4:40:59am
The Effects of Gene Regulation on Aging in Caenorhabditis elegans (2003) Dasia Garcia In 2003, molecular biology and genetics researchers Coleen T. Murphy, Steven A. McCarroll, Cornelia I. Bargmann, Andrew Fraser, Ravi S. Kamath, Julie Ahringer, Hao Li, and Cynthia Kenyon conducted an experiment that investigated the cellular aging in, Caenorhabditis elegans (C. elegans) nematodes. The researchers investigated the interactions between the transcription factor DAF-16 and the genes that regulate the production of an insulin-like growth factor 1 (IGF-1-like) protein related to the development, reproduction, and aging in C. elegans. 2017-02-16 4 Jul 2018 - 4:40:59am
"Transfer of Fetal Cells with Multilineage Potential to Maternal Tissue" (2004), by Kiarash Khosrotehrani et al. Alexis Abboud In 2004, a team of researchers at Tufts-New England Medical Center in Boston, Massachusetts, investigated the fetal cells that remained in the maternal blood stream after pregnancy. The results were published in Transfer of Fetal Cells with Multilineage Potential to Maternal Tissue. The team working on that research included Kiarash Khosrotehrani, Kirby L. Johnson, Dong Hyun Cha, Robert N. Salomon, and Diana W. Bianchi. The researchers reported that the fetal cells passed to a pregnant woman during 2014-11-14 4 Jul 2018 - 4:40:59am
"β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis" (2007), by Kyle A. Gurley, Jochen C. Rink, and Alejandro Sánchez Alvarado Mary E. Sunderland Alejandro Sánchez Alvarado's laboratory group has employed molecular tools to investigate old questions about regeneration and as a result have identified some of the molecular mechanisms determining polarity. Recent work by his group has shown Wnt-β-catenin signaling determines whether a tail or a head will form during regeneration in planarians. This study was motivated by work Thomas Hunt Morgan conducted in the late nineteenth century. 2010-03-15 4 Jul 2018 - 4:40:59am
"Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (t12/t12)-Normal Mosaics" (1964), by Beatrice Mintz Adam R. Navis The paper "Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (t12/t12)-Normal Mosaics," by Beatrice Mintz, describes a technique to fuse two mouse embryos into a single embryo. This work was published in the Journal of Experimental Zoology in 1964. When two embryos are correctly joined before the 32-cell stage, the embryo will develop normally and exhibit a mosaic pattern of cells as an adult. 2009-01-13 4 Jul 2018 - 4:40:59am
"The Developmental Capacity of Nuclei Taken from Intestinal Epithelium Cells of Feeding Tadpoles" (1962), by John B. Gurdon Giselle Lee In 1962 researcher John Bertrand Gurdon at the University of Oxford in Oxford, England, conducted a series of experiments on the developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. In the experiments, Gurdon conducted nuclear transplantation, or cloning, of differentiated cells, or cells that have already specialized to become one cell type or another, in tadpoles. Gurdon's experiment showed that differentiated adult cells could be induced to an undifferentiated state, where they could once again become multiple cell types. 2017-03-16 4 Jul 2018 - 4:40:59am
"Human Factor IX Transgenic Sheep Produced by Transfer of Nuclei from Transfected Fetal Fibroblasts" (1997), by Angelika E. Schnieke, et al. Zane Bartlett In the 1990s, researchers working at the Roslin Institute in Edinburgh, Scotland, performed cloning experiments in collaboration with PPL Therapeutics in Roslin, Scotland, on human coagulation factor IX, a protein. The team of scientists used the methods identified during the Dolly experiments to produce transgenic livestock capable of producing milk containing human blood clotting factor IX, which helps to treat a type of hemophilia. 2014-08-19 4 Jul 2018 - 4:40:59am
CRISPR Acquired Resistance Against Viruses (2007) Meilin Zhu In 2007, Philippe Horvath and his colleagues explained how bacteria protect themselves against viruses at Danisco, a Danish food company, in Dangé-Saint-Romain, France. Horvath and his team worked to improve the lifespan of bacteria cultures for manufacturing yogurt and ice cream. Specifically, they focused on bacteria’s resistance to bacteriophages, or viruses that infect bacteria. Horvath and his colleagues found that the bacteria used to culture yogurt, Streptococcus thermophilus, has an adaptive immune system that can target specific viruses that have previously infected the bacteria. 2017-11-15 4 Jul 2018 - 4:40:59am
The Discovery of p53 Protein Lijing Jiang The p53 protein acts as a pivotal suppressor of inappropriate cell proliferation. By initiating suppressive effects through induction of apoptosis, cell senescence, or transient cell-cycle arrest, p53 plays an important role in cancer suppression, developmental regulation, and aging. Its discovery in 1979 was a product of research into viral etiology and the immunology of cancer. The p53 protein was first identified in a study of the role of viruses in cancer through its ability to form a complex with viral tumor antigens. 2011-01-21 4 Jul 2018 - 4:40:59am
"Sheep Cloned by Nuclear Transfer from a Cultured Cell Line" (1996), by Keith Campbell, Jim McWhir, William Ritchie, and Ian Wilmut Zane Bartlett In 1995 and 1996, researchers at the Roslin Institute in Edinburgh, Scotland, cloned mammals for the first time. Keith Campbell, Jim McWhir, William Ritchie, and Ian Wilmut cloned two sheep, Megan and Morag, using sheep embryo cells. The experiments indicated how to reprogram nuclei from differentiated cells to produce live offspring, and that a single population of differentiated cells could produce multiple offspring. They reported their results in the article 'Sheep Cloned by Nuclear Transfer from a Cultured Cell Line' in March 1996. 2014-09-19 4 Jul 2018 - 4:40:59am
"The linear arrangement of six sex-linked factors in drosophila, as shown by their mode of association” (1913), by Alfred Henry Sturtevant Kevin Gleason In 1913, Alfred Henry Sturtevant published the results of experiments in which he showed how genes are arranged along a chromosome. Sturtevant performed those experiments as an undergraduate at Columbia University, in New York, New York, under the guidance of Nobel laureate Thomas Hunt Morgan. Sturtevant studied heredity using Drosophila, the common fruit fly. In his experiments, Sturtevant determined the relative positions of six genetic factors on a fly’s chromosome by creating a process called gene mapping. 2017-05-22 4 Jul 2018 - 4:40:59am
Corticosteroids' Effect on Fetal Lung Maturation (1972), by Sir Graham Collingwood Liggins and Ross Howie Kathleen O'Connor, Erica O'Neil In a clinical trial from 1969 to 1972, Sir Graham Collingwood Liggins and Ross Howie showed that if doctors treat pregnant women with corticosteroids before those women deliver prematurely, then those women's infants have fewer cases of respiratory distress syndrome than do similarly premature infants of women not treated with corticosteroids. Prior to the study, premature infants born before 32 weeks of gestation often died of respiratory distress syndrome, or the inability to inflate immature lungs. 2012-12-19 4 Jul 2018 - 4:40:59am
Gene Transfer Strategy Used to Treat Tay - Sachs Disease (2005), by Sabata Martino’s Research Group Tiffany Nardi In the early 2000s, Sabata Martino and a team of researchers in Italy and Germany showed that they could reduce the symptoms of Tay-Sachs in afflicted mice by injecting them with a virus that infected their cells with a gene they lacked. Tay-Sachs disease is a fatal degenerative disorder that occurs in infants and causes rapid motor and mental impairment, leading to death at the ages of three to five. In gene therapy, researchers insert normal genes into cells that have missing or defective genes in order to correct genetic disorders. 2017-02-21 4 Jul 2018 - 4:40:59am
"Maternal Thyroid Deficiency During Pregnancy and Subsequent Neuropsychological Development of the Child" (1999), by James E. Haddow et al. Jennifer R. Craer From 1987 to the late 1990s, James Haddow and his team of researchers at the Foundation for Blood Research in Scarborough, Maine, studied children born to women who had thyroid deficiencies while pregnant with those children. Haddow's team focused the study on newborns who had normal thyroid function at the time of neonatal screening. They tested the intelligence quotient, or IQ, of the children, ages eight to eleven years, and found that all of the children born to thyroid-hormone deficient mothers performed less well than the control group. 2014-07-11 4 Jul 2018 - 4:40:59am
"Selective Growth Stimulating Effects of Mouse Sarcoma on the Sensory and Sympathetic Nervous System of the Chick Embryo" (1951), by Rita Levi-Montalcini and Viktor Hamburger Adam R. Navis In "Selective Growth Stimulating Effects of Mouse Sarcoma on the Sensory and Sympathetic Nervous System of the Chick Embryo," Rita Levi-Montalcini and Viktor Hamburger explored the effects of two nerve growth stimulating tumors; mouse sarcomas 180 and 37. This experiment led to the discovery that nerve growth factor was a diffusible chemical and later to discoveries that the compound was a protein. Although this paper was an important step in the discovery of nerve growth factor, the term "nerve growth factor" was not used in this paper. 2007-10-30 4 Jul 2018 - 4:40:59am
Infant Mortality: Results of a Field Study in Johnstown, PA., Based on Births in One Calendar Year (1915), by Emma Duke Katherine Madgett The book Infant Mortality: Results of a Field Study in Johnstown, PA., Based on Births in One Calendar Year (1915), written by Emma Duke, detailed one of the first infant mortality field studies conducted by the US Children's Bureau. In the study, Duke and her colleagues collected information about over one thousand infants in the city of Johnstown, Pennsylvania. They used that information, along with interviews conducted with the families of the infants, to identify factors that affected infant mortality rates in the community. 2017-03-23 4 Jul 2018 - 4:40:59am
Paul Kammerer's Experiments on Salamanders (1903-1912) Federica Turriziani Colonna In the early twentieth century, Paul Kammerer conducted a series of experiments to demonstrate that organisms could transmit characteristics acquired in their lifetimes to their offspring. In his 1809 publication, zoologist Jean-Baptiste Lamarck had hypothesized that living beings can inherit features their parents or ancestors acquired throughout life. By breeding salamanders, as well as frogs and other organisms, Kammerer tested Lamarck's hypothesis in an attempt to provide evidence for Lamarck's theory of the inheritance of acquired characteristics. 2014-12-30 4 Jul 2018 - 4:40:59am
Robert Geoffrey Edwards's Study of Fertilization of Human Oocytes Matured in vitro, 1965 to 1969 Lijing Jiang Robert Geoffrey Edwards, a British developmental biologist at University of Cambridge, began exploring human in vitro fertilization (IVF) as a way to treat infertility in 1960. After successfully overcoming the problem of making mammalian oocytes mature in vitro in 1965, Edwards began to experiment with fertilizing matured eggs in vitro. Collaborating with other researchers, Edwards eventually fertilized a human egg in vitro in 1969. This was a huge step towards establishing human IVF as a viable fertility treatment. 2011-03-10 4 Jul 2018 - 4:40:59am
"A Series of Normal Stages in the Development of the Chick Embryo" (1951), by Viktor Hamburger and Howard L. Hamilton Adam R. Navis The developmental stages of the chick embryo were examined by Viktor Hamburger and Howard L. Hamilton in "A Series of Normal Stages in the Development of the Chick Embryo," published in the Journal of Morphology in 1951. These stages were published to standardize the development of the chick based on varying laboratory conditions and genetic differences. The stages Hamburger and Hamilton assigned were determined by the visible features of the chick embryo. 2007-10-30 4 Jul 2018 - 4:40:59am
"A molecular wound response program associated with regeneration initiation in planarians" (2012), by Danielle Wenemoser et al. Joe Brinkman In 2012, a team of scientists across the US conducted an experiment to find the mechanism that allowed a group of flatworms, planarians, to regenerate any body part. The group included Danielle Wenemoser, Sylvain Lapan, Alex Wilkinson, George Bell, and Peter Reddien. They aimed to identify genes that are expressed by planarians in response to wounds that initiated a regenerative mechanism. The researchers determined several genes as important for tissue regeneration. 2017-05-09 4 Jul 2018 - 4:40:59am
Frank Rattray Lillie's Study of Freemartins (1914-1920) Mary Drago Frank Rattray Lillie's research on freemartins from 1914 to 1920 in the US led to the theory that hormones partly caused for sex differentiation in mammals. Although sometimes applied to sheep, goats, and pigs, the term freemartin most often refers to a sterile cow that has external female genitalia and internal male gonads and was born with a normal male twin. 2014-03-14 4 Jul 2018 - 4:40:59am
"The Development of the Turtle Carapace" (1989), by Ann Campbell Burke Guido Caniglia Ann Campbell Burke examines the development and evolution of vertebrates, in particular, turtles. Her Harvard University experiments, described in Development of the Turtle Carapace: Implications for the Evolution of a Novel Bauplan, were published in 1989. Burke used molecular techniques to investigate the developmental mechanisms responsible for the formation of the turtle shell. 2011-10-20 4 Jul 2018 - 4:40:59am
"Human Toxoplasmosis: Occurrence in Infants as an Encephalomyelitis Verification of Transmission to Animals" (1939), by Abner Wolf et al. Jesse Potestas In a series of experiments during mid 1930s, a team of researchers in New York helped establish that bacteria of the species Toxoplasma gondii can infect humans, and in infants can cause toxoplasmosis, a disease that inflames brains, lungs, and hearts, and that can organisms that have it. The team included Abner Wolf, David Cowen, and Beryl Paige. They published the results of their experiment in Human Toxoplasmosis: Occurrence in Infants as an Encephalomyelitis Verification of Transmission to Animals. 2015-06-11 4 Jul 2018 - 4:40:59am
"CRISPR /Cas9-mediated Gene Editing in Human Tripronuclear Zygotes" (2015), by Junjiu Huang et al. Meilin Zhu In 2015, Junjiu Huang and his colleagues reported their attempt to enable CRISPR/cas 9-mediated gene editing in nonviable human zygotes for the first time at Sun Yat-Sen University in Guangzhou, China. Their article, CRISPR /Cas9-mediated Gene Editing in Human Tripronuclear Zygotes, was published in Protein and Cell. Nonviable zygotes are sperm-fertilized eggs that cannot develop into a fetus. Researchers previously developed the CRISPR/cas 9 gene editing tool, which is a system that originated from bacteria as a defense mechanism against viruses. 2017-11-08 4 Jul 2018 - 4:40:59am
"Experiments on the Development of Chick and Duck Embryos, Cultivated in vitro" (1932), by Conrad Hal Waddington Adam R. Navis Conrad Hal Waddington's "Experiments on the Development of Chick and Duck Embryos, Cultivated in vitro," published in 1932 in Philosophical Transactions of the Royal Society of London, Series B, compares the differences in the development of birds and amphibians. Previous experiments focused on the self differentiation of individual tissues in birds, but Waddington wanted to study induction in greater detail. The limit to these studies had been the amount of time an embryo could be successfully cultivated ex vivo. 2007-11-08 4 Jul 2018 - 4:40:59am
Beadle and Ephrussi Show that Something Besides Eye Tissue Determines Eye Color in Fruit Flies Amy Pribadi In the 1930s, George Beadle and Boris Ephrussi discovered factors that affect eye colors in developing fruit flies. They did so while working at the California Institute of Technology in Pasadena, California. (1) They took optic discs (colored fuchsia in the image) from fruit fly larvae in the third instar stage of development. Had the flies not been manipulated, they would have developed into adults with vermilion eyes. 2016-10-11 4 Jul 2018 - 4:40:59am