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Treatment of Pelvic Organ Prolapse in Women
Pelvic organ prolapse is a common condition in women that causes the pelvic organs to descend, often resulting from a weakened pelvic floor. Pelvic organs supported by the pelvic floor, such as the bladder, bowel, or uterus, can descend to such a degree that they project out from a woman’s body typically via the vagina. Pelvic floor stress or trauma, like vaginal childbirth, can cause pelvic organ prolapse. Women with pelvic organ prolapse also often experience other conditions, such as incontinence or the involuntary leakage of urine or fecal matter.
Subject: Reproduction, Disorders, Processes
Thesis: Growing Human Organs in Animals: Interspecies Blastocyst Complementation as a Potential Solution for Organ Transplant Limitations
To address the progression of immune-related constraints on organ transplantation, the first part of this thesis contains a historical analysis tracing early transplant motivations and the events that led to the discoveries broadly related to tolerance, rejection, and compatibility. Despite the advancement of those concepts over time, this early history shows that immunosuppression was one of the earliest limiting barriers to successful organ transplantation, and remains one of the most significant technical challenges.
Format: Essays and Theses
Dictyostelium discoideum is a cellular slime mold that serves as an important model organism in a variety of fields. Cellular slime molds have an unusual life cycle. They exist as separate amoebae, but after consuming all the bacteria in their area they proceed to stream together to form a multicellular organism. These features make it a valuable tool for studying developmental processes and also for investigating the evolution of multicellularity. Long thought to be a type of fungus, it has recently been shown that slime molds in fact bear no relation to fungi.
"A Stochastic Model of Stem Cell Proliferation, Based on the Growth of Spleen Colony-Forming Cells” (1964) by James Till, Ernest McCulloch, and Louis Siminovitch
In 1964, authors James Till, Ernest McCulloch, and Louis Siminovitch, published A Stochastic Model of Stem Cell Proliferation, Based on The Growth of Spleen Colony-Forming Cells, which discussed possible mechanisms that control stem cell division. The authors wrote the article following their experiments with spleens of irradiated mice to demonstrate the existence of stem cells, had unknown properties.
Hamburger-Hamilton Staging Series (1951)
In 1951 Viktor Hamburger and Howard Hamilton created an embryonic staging series from a combination of photographs and drawings from other researchers. The Hamburger-Hamilton stages are a sequence of images depicting 46 chronological stages in chick development. The images begin with a fertilized egg and end with a fully developed chick. The Hamburger-Hamilton staging series was produced in order to replace a previous chick staging series created in 1900. The earlier attempt lacked specific details and staged the chick embryo by using only morphological characteristics.
"Induction and Patterning of the Primitive Streak, an Organizing Center of Gastrulation in the Amniote" (2004), by Takashi Mikawa, Alisa M. Poh, Kristine A. Kelly, Yasuo Ishii, and David E. Reese
"Induction and Patterning of the Primitive Streak, an Organizing Center of Gastrulation in the Amniote," (hereafter referred to as "Induction") examines the mechanisms underlying early amniote gastrulation and the formation of the primitive streak and midline axis. The review, authored by Takashi Mikawa and colleagues at Cornell University Medical College, was published in Developmental Dynamics in 2004.
The Source-Sink Model
The source-sink model, first proposed by biologist Francis Crick in 1970, is a theoretical system for how morphogens distribute themselves across small fields of early embryonic cells. A morphogen is a substance that determines the fate and phenotype of a group of cells through a concentration gradient of itself across that group. Crick’s theory has been experimentally confirmed with several morphogens, most notably with the protein bicoid , the first discovered morphogen. The model provides a theoretical structure for the understanding of some features of early embryonic development.
“Levator Trauma is Associated with Pelvic Organ Prolapse” (2008), by Hans P. Dietz and Judy M. Simpson
Hans Peter Dietz and Judy Simpson published, “Levator Trauma is Associated with Pelvic Organ Prolapse,” in the journal BJOG: An International Journal of Obstetrics and Gynecology in 2008. In their article, Dietz and Simpson estimated the risk of pelvic organ prolapse in women who attained injuries to the pelvic levator muscles. The levator muscles, also known as the levator ani, are a major muscle group that comprise the pelvic floor. Along with other muscles, the pelvic floor supports organs in a woman’s pelvis, such as the bladder, uterus, and rectum.
Subject: Publications, Disorders
“Pelvic Organ Prolapse” (2007), by John E. Jelovsek, Christopher Maher, and Matthew D. Barber
In 2007, physicians John Jelovsek, Christopher Maher, and Matthew Barber published, “Pelvic Organ Prolapse,” in The Lancet. In their article, Jelovsek and colleagues provided an overview of pelvic organ prolapse in women and described the epidemiology, risk factors, symptoms, and management of the condition. Pelvic organ prolapse occurs when a woman’s pelvic floor is weakened or damaged from stress or trauma such as vaginal childbirth.
Subject: Publications, Disorders
Making Visible Embryos (2008- ), by Tatjana Buklijaz and Nick Hopwood
Making Visible Embryos is a 2008 online exhibition of embryos authored and designed by Tatjana Buklijaz and Nick Hopwood who work in the Department of History and Philosophy of Science at the University of Cambridge. Hopwood's research on the history of Ziegler wax models and the use of visual aids to promote the teaching and learning of science is well known.
Subject: Organizations, Outreach
The Jackson Laboratory
The Roscoe B. Jackson Laboratory, known commonly in the scientific field as the Jackson Laboratory, was founded by Clarence Cook Little in May 1929. The lab has been pivotal in research with in vitro fertilization, teratomas, gene replacement therapy for birth defects, and more because its researchers have focused from the beginning on developing the mouse as a model organism. Mice were chosen by researchers at Jackson as the best available model for genetic research, and today genetically uniform strains of mice developed at the lab are used in laboratories all over the world.
The US President's Council on Bioethics (2001-2009)
The US President's Council on Bioethics was an organization headquartered in Washington D.C. that was chartered to advise then US President George W. Bush on ethical issues related to biomedical science and technology. In November 2001, US President George W. Bush created the President's Council on Bioethics (PCB). Convened during a nationwide cloning and embryonic stem cell research debate, the Council stated that it worked to address arguments about ethics from many different perspectives.
Subject: Organizations, Legal, Ethics
Inducing Fertilization and Development in Sand Dollars
Sand dollars are common marine invertebrates in the phylum Echinodermata and share the same class (Echinoidea) as sea urchins. They have served as model laboratory organisms for such embryologists as Frank Rattray Lillie and Ernest Everett Just. Both Lillie and Just used Echinarachnius parma for their studies of egg cell membranes and embryo development at the Marine Biological Laboratory (MBL) at Woods Hole, Massachusetts, in the early 1900s.
Gastrulation in Mus musculus (common house mouse)
As mice embryos develop, they undergo a stage of development called gastrulation. The hallmark of vertebrate gastrulation is the reorganization of the inner cell mass (ICM) into the three germ layers: ectoderm, mesoderm, and endoderm. Mammalian embryogenesis occurs within organisms; therefore, gastrulation was originally described in species with easily observable embryos. For example, the African clawed frog (Xenopus laevis) is the most widely used organism to study gastrulation because the large embryos develop inside a translucent membrane.
Subject: Processes, Experiments
Stazione Zoologica Anton Dohrn, Naples, Italy
The Stazione Zoologica Anton Dohrn (Anton Dohrn Zoological Station) is a public research institute focusing on biology and biodiversity. Hereafter called the Station, it was founded in Naples, Italy, in 1872 by Anton Dohrn. The type of research conducted at the Station has varied since it was created, though initial research focused on embryology. At the turn of the twentieth century, researchers at the Station established the sea urchin (Echinoidea) as a model organism for embryological research.
Subject: Organizations, People, Places
World Health Organization Guidelines (Option A, B, and B+) for Antiretroviral Drugs to Treat Pregnant Women and Prevent HIV Infection in Infants
To address the international Human Immunodeficiency Virus epidemic, the World Health Organization, or WHO, developed three drug treatment regimens between 2010 and 2012 specifically for HIV-positive pregnant women and their infants. WHO developed the regimens, calling them Option A, Option B, and Option B+, to reduce or prevent mother-to-child, abbreviated MTC, transmission of HIV. Each option comprises of different types and schedules of antiretroviral medications. As of 2018, WHO reported that in Africa alone about 1,200,000 pregnant women were living with untreated HIV.
Subject: Reproduction, Processes, Disorders
Human Betterment Foundation (1928-1942)
In 1928 Ezra Seymour Gosney founded the non-profit Human Betterment Foundation (HBF) in Pasadena, California to support the research and publication of the personal and social effects of eugenic sterilizations carried out in California. Led by director Gosney and secretary Paul Popenoe, the HBF collected data on thousands of individuals in California who had been involuntarily sterilized under a California state law enacted in 1909. The Foundation's assets were liquidated following Gosney's death in 1942.
Subject: Organizations, Reproduction
Lysogenic Bacteria as an Experimental Model at the Pasteur Institute (1915-1965)
Lysogenic bacteria, or virus-infected bacteria, were the primary experimental models used by scientists working in the laboratories of the Pasteur Institute in Paris, France, during the 1950s and 1960s. Historians of science have noted that the use of lysogenic bacteria as a model in microbiological research influenced the scientific achievements of the Pasteur Institute's scientists.
Subject: Organisms, Experiments
The French Flag Model
The French flag model represents how embryonic cells receive and respond to genetic information and subsequently differentiate into patterns. Created by Lewis Wolpert in the late 1960s, the model uses the French tricolor flag as visual representation to explain how embryonic cells can interpret genetic code to create the same pattern even when certain pieces of the embryo are removed. Wolpert's model has provided crucial theoretical framework for investigating universal mechanisms of pattern formation during development.
The Pasteur Institute (1887- )
L'Institut Pasteur (The Pasteur Institute) is a non-profit private research institution founded by Louis Pasteur on 4 June 1887 in Paris, France. The Institute's research focuses on the study of infectious diseases, micro-organisms, viruses, and vaccines. As of 2014, ten scientists have received Nobel Prizes in physiology or medicine for the research they have done at the Pasteur Institute.
Carnegie Institution of Washington Department of Embryology
The Carnegie Institution of Washington's (CIW) Embryology Department was opened in 1914 and remains one of six departments in the CIW. The department quickly became, and remains, world renowned for its many embryonic development discoveries. In 1913 Franklin P. Mall, Professor of Anatomy at Johns Hopkins Medical School, applied for a Carnegie grant to support his research with human embryos. Mall had a collection of over 800 human embryo specimens and was at the point of wanting to do more than just collect.
The Eugenics Record Office at Cold Spring Harbor Laboratory (1910-1939)
From its founding in 1910 until it closed its doors in 1939, the Eugenics Record Office (ERO) at Cold Spring Harbor Laboratory in New York was the center of the American Eugenics Movement. Charles Davenport, a geneticist and biologist, founded the ERO, and served as its director until 1934. Under the direction of Davenport and his associate, superintendant Harry H. Laughlin, the influence of the ERO on science and public policy waxed during the early twentieth century until after World War II.
Subject: Organizations, Reproduction
Women’s Field Army (1936–1948)
From 1936 to 1945, the Women’s Field Army, hereafter the WFA, educated women in the US on the early symptoms, prevention, and treatment of reproductive cancers. The WFA was a women-led volunteer organization and a branch of, what was then called, the American Society for the Control of Cancer, or ASCC. The WFA, headquartered in New York City, New York, recruited hundreds of thousands of women volunteers across the country.
Alexandre Lion’s Incubator Charities in Europe (1894–1898)
Alexandre Lion established incubator charities in the late 1890s in France to promote his infant incubator. Lion’s infant incubators kept premature infants warm and improved their chances of survival, but were expensive and not widely used. In order to promote his new technology, Lion displayed incubators that carried premature infants in storefronts and at fairs and expositions throughout Europe. After the public began paying admission to view the infants and incubators, the expositions became incubator charities. Admission fees went directly to the care of the premature infants.
The Doula Project (2007– )
The Doula Project, cofounded in 2007 as The Abortion Doula Project by Mary Mahoney, Lauren Mitchell, and Miriam Zoila Perez, is a nonprofit organization of full-spectrum doulas based in New York City, New York, and is one of the first organizations to provide free full-spectrum doula care to pregnant people. Full-spectrum doulas provide non-medical physical, emotional, and informational support to pregnant people through a wide range of pregnancy experiences, including birth, miscarriage, stillbirth, fetal anomalies, and abortion.
Subject: Organizations, Outreach, Ethics, Reproduction