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Peter Mazur (1928–2015)
Peter Mazur was a researcher in the US who developed new ways of preserving biological material by freezing it, a process called cryopreservation. If done correctly, cryopreservation enables scientists to store or study biological material for an extended period of time. If done incorrectly, cryopreservation can easily harm or destroy biological material. Mazur worked to find the best ways to cryopreserve different cells, embryos, and organs in order to minimize the damage caused by freezing.
Historically the exact age of human embryo specimens has long perplexed embryologists. With the menstrual history of the mother often unknown or not exact, and the premenstrual and postmenstrual phases varying considerably among women, age sometimes came down to a best guess based on the weight and size of the embryo. Wilhelm His was one of the first to write comparative descriptions of human embryos in the late 1800s. Soon afterward, Franklin P. Mall, the first director of the Carnegie Institution of Washington's (CIW) Department of Embryology, expanded upon His' work.
Individuals with Disabilities Education Act (1975)
In 1975, the United States Congress passed the Individuals with Disabilities Education Act, referred to as the IDEA, which codified the right of all American children to a free and appropriate public education regardless of disability status. The IDEA requires all public schools that accept federal funds to provide education that meets the needs of students with disabilities at the public expense. Prior to IDEA, many students with disabilities went without any educational opportunities, and many faced confinement in institutions.
"Hybrids and Chimeras: A Consultation on the Ethical and Social Implications of Creating Human/Animal Embryos in Research" (2007), by the HFEA
To educate its citizens about research into chimeras made from human and non-human animal cells, the United Kingdom's Human Fertilisation Embryology Authority published the consultation piece Hybrids and Chimeras: A Consultation on the Ethical and Social Implications of Creating Human/Animal Embryos in Research, in 2007.
Human Fertilisation and Embryology Act (1990)
The Human Fertilisation and Embryology Act 1990 established the legal framework that governs infertility treatment, medical services ancillary to infertility treatment such as embryo storage, and all human embryological research performed in the UK. The law also defines a legal concept of the parent of a child conceived with assisted reproductive technologies.
Subject: Legal, Reproduction, Ethics
"Embryonic Stem Cell Lines Derived from Human Blastocytes" (1998), by James Thomson
After becoming chief pathologist at the University of Wisconsin-Madison Wisconsin Regional Primate Center in 1995, James A. Thomson began his pioneering work in deriving embryonic stem cells from isolated embryos. That same year, Thomson published his first paper, "Isolation of a Primate Embryonic Stem Cell Line," in Proceedings of the National Academy of Sciences of the United States of America, detailing the first derivation of primate embryonic stem cells. In the following years, Thomson and his team of scientists - Joseph Itskovitz-Eldor, Sander S. Shapiro, Michelle A.
Subject: Experiments, Publications
Human Evolution Inferred from Tooth Growth and Development
To study human evolution, researchers sometimes use microstructures found in human teeth and their knowledge of the processes by which those structures grow. Human fetusus begin to develop teeth in utero. As teeth grow, they form a hard outer substance, called enamel, through a process called amelogenesis. During amelogenesis, incremental layers of enamel form in a Circadian rhythm. This rhythmic deposition leaves the enamel with microstructures, called cross-striations and striae of Retzius, which have a regular periodicity.
Arizona State University Embryo Project Photograph Collections
In the 1970s Stanford University Embryologist Harold Heath sent a box of photographs to Frederick B. Churchill, who was a Professor in the History and Philosophy of Science Department at Indiana University. Heath was born in Indiana, he knew that Churchill was the leading historian of embryology, and he wanted his photographs to be used and therefore wanted them to be housed somewhere with an interest in the history of biology. Heath made it clear that he was donating the photographs for use by scholars and the public.
Edwin Carlyle (Carl) Wood (1929–2011)
Edwin Carlyle Wood, also known as Carl Wood, was a physician who helped develop in vitro fertilization, or IVF, treatments. From 1964 to 1992, Wood worked as a professor of obstetrics and gynecology at Monash University in Melbourne, Australia, where he was one of the first in the world to lead a team of physicians to establish IVF as a proven treatment for infertility. IVF refers to a medical procedure in which scientists inseminate an egg cell with a sperm cell outside of the body, such as in a glass dish in a clinical setting.
Subject: People, Technologies, Reproduction
Dana Louise Raphael (1926–2016)
Dana Louise Raphael was an anthropologist and breastfeeding advocate in the US during the twentieth century. After she was unable to breastfeed her own infant, Raphael began to research why breastfeeding was more common in other cultures than in the US. As part of that research, Raphael cofounded the Human Lactation Center, where she studied the breastfeeding habits of mothers around the world. Through that research, she coordinated with formula manufacturers to educate women on the benefits of breastfeeding and formula supplementation to reduce infant mortality in developing nations.
Robert Geoffrey Edwards and Patrick Christopher Steptoe's Clinical Research in Human in vitro Fertilization and Embryo Transfer, 1969-1980
The biomedical accomplishment of human in vitro fertilization and embryo transfer (IVF-ET) took years to become the successful technique that presently enables infertile couples to have their own children. In 1969, more than ten years after the first attempts to treat infertilities with IVF technologies, the British developmental biologist Robert Geoffrey Edwards fertilized human oocytes in a Petri dish for the first time.
Subject: Experiments, Reproduction
"Mechanistic Science and Metaphysical Romance" (1915), by Jacques Loeb
Jacques Loeb published "Mechanistic Science and Metaphysical Romance" in 1915. His goal for the article was to outline his conception of mechanistic science and its relation to other methods of inquiry. Loeb argued that mechanistic science was the foundation of knowledge and humanity's progress depended on it. Loeb's argument altered the account of science he offered in The Mechanistic Conception of Life insofar as scientists no longer aimed merely to control nature, but also to understand nature s underlying elements and their mechanical relations.
Carnegie Institution of Washington Department of Embryology
The Carnegie Institution of Washington's (CIW) Embryology Department was opened in 1914 and remains one of six departments in the CIW. The department quickly became, and remains, world renowned for its many embryonic development discoveries. In 1913 Franklin P. Mall, Professor of Anatomy at Johns Hopkins Medical School, applied for a Carnegie grant to support his research with human embryos. Mall had a collection of over 800 human embryo specimens and was at the point of wanting to do more than just collect.
Assisted Human Reproduction Act (2004)
The Assisted Human Reproduction Act (AHR Act) is a piece of federal legislation passed by the Parliament of Canada. The Act came into force on 29 March 2004. Many sections of the Act were struck down following a 2010 Supreme Court of Canada ruling on its constitutionality. The AHR Act sets a legislative and regulatory framework for the use of reproductive technologies such as in vitro fertilization and related services including surrogacy and gamete donation. The Act also regulates research in Canada involving in vitro embryos.
Subject: Legal, Reproduction, Ethics
Dickey-Wicker Amendment, 1996
The Dickey-Wicker Amendment is an amendment attached to the appropriations bills for the Departments of Health and Human Services, Labor, and Education each year since 1996 restricting the use of federal funds for creating, destroying, or knowingly injuring human embryos. The Dickey-Wicker Amendment began as a rider (another name for an amendment) attached to House Resolution (H.R.) 2880. H.R.
The Human Genome Project (1990-2003)
The Human Genome Project (HGP) was an international scientific effort to sequence the entire human genome, that is, to produce a map of the base pairs of DNA in the human chromosomes, most of which do not vary among individuals. The HGP started in the US in 1990 as a public effort and included scientists and laboratories located in France, Germany, Japan, China, and the United Kingdom.
Human Betterment Foundation (1928-1942)
In 1928 Ezra Seymour Gosney founded the non-profit Human Betterment Foundation (HBF) in Pasadena, California to support the research and publication of the personal and social effects of eugenic sterilizations carried out in California. Led by director Gosney and secretary Paul Popenoe, the HBF collected data on thousands of individuals in California who had been involuntarily sterilized under a California state law enacted in 1909. The Foundation's assets were liquidated following Gosney's death in 1942.
Subject: Organizations, Reproduction
Mitochondrial Diseases in Humans
Mitochondrial diseases in humans result when the small organelles called mitochondria, which exist in all human cells, fail to function normally. The mitochondria contain their own mitochondrial DNA (mtDNA) separate from the cell's nuclear DNA (nDNA). The main function of mitochondria is to produce energy for the cell. They also function in a diverse set of mechanisms such as calcium hemostasis, cell signaling, regulation of programmed cell death (apoptosis), and biosynthesis of heme proteins that carry oxygen.
Subject: Disorders, Reproduction
Estrogen and the Menstrual Cycle in Humans
Estrogen is the primary sex hormone in women and it functions during the reproductive menstrual cycle. Women have three major types of estrogen: estrone, estradiol, and estriol, which bind to and activate receptors within the body. Researchers discovered the three types of estrogen over a period of seven years, contributing to more detailed descriptions of the menstrual cycle. Each type of estrogen molecule contains a slightly different arrangement or number of atoms that in turn causes some of the estrogens to be more active than others.
Subject: Theories, Reproduction
The French Flag Model
The French flag model represents how embryonic cells receive and respond to genetic information and subsequently differentiate into patterns. Created by Lewis Wolpert in the late 1960s, the model uses the French tricolor flag as visual representation to explain how embryonic cells can interpret genetic code to create the same pattern even when certain pieces of the embryo are removed. Wolpert's model has provided crucial theoretical framework for investigating universal mechanisms of pattern formation during development.
Camillo Golgi (1843–1926)
Camillo Golgi studied the central nervous system during the late nineteenth and early twentieth centuries in Italy, and he developed a staining technique to visualize brain cells. Called the black reaction, Golgi’s staining technique enabled him to see the cellular structure of brain cells, called neurons, with much greater precision. Golgi also used the black reaction to identify structures within animal cells like the internal reticular apparatus that stores, packs, and modifies proteins, later named the Golgi apparatus in his honor.
St. Thomas Aquinas (c. 1225-1274)
Widely known as a key contributor to the Roman Catholic Church's body of doctrine, St. Thomas Aquinas also published an opinion on the moral status of embryos and fetuses that seems contradictory to the Catholic Church's current standpoint on the matter. Born in Naples, Italy, around 1225 (scholars debate the exact year of many of his life events) to wealthy nobility, Thomas Aquinas quickly proved himself a pious and astute scholar with an insatiable desire for logic and understanding.
Many difficulties can arise with a pregnancy even after the sperm successfully fertilizes the oocyte. A major problem occurs if the fertilized egg tries to implant before reaching its normal implantation site, the uterus. An ectopic pregnancy occurs when a fertilized egg implants anywhere other than in the uterus, most commonly in the fallopian tubes. Ectopic pregnancies cannot continue to term, so a physician must remove the developing embryo as early as possible.
Subject: Disorders, Processes, Reproduction
Assisted Human Reproduction Canada (AHRC)
Established under the Assisted Human Reproduction (AHR) Act of 2004, Assisted Human Reproduction Canada (AHRC), also known as the Assisted Human Reproduction Agency of Canada, was created in 2006 to oversee research related to reproductive technologies and to protect the reproductive rights and interests of Canadian citizens. AHRC serves as a regulatory body for the development and use of such research and technology while enforcing the guidelines and restrictions laid out by the AHR Act.
Subject: Organizations, Reproduction
George Linius Streeter (1873-1948)
George Linius Streeter was born on 12 January 1873 in Johnstown, New York, to Hannah Green Anthony and George Austin Streeter. He completed his undergraduate studies at Union College in 1895 and received his MD degree from the College of Physicians and Surgeons of Columbia University in 1899. At Columbia, Professor George S. Huntington sparked Streeter's interest in anatomy, and Streeter also interned at Roosevelt Hospital in New York City. He then went on to Albany to teach anatomy at the Albany Medical College and to work with neurologist Henry Hun.