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Displaying 876 - 900 of 1053 items.

"A Diffusible Agent of Mouse Sarcoma, Producing Hyperplasia of Sympathetic Ganglia and Hyperneurotization of Viscera in the Chick Embryo" (1953), by Rita Levi-Montalcini and Viktor Hamburger

"A Diffusible Agent of Mouse Sarcoma, Producing Hyperplasia of Sympathetic Ganglia and Hyperneurotization of Viscera in the Chick Embryo," by Rita Levi-Montalcini and Viktor Hamburger, appeared in 1953 in the Journal of Experimental Zoology. The paper provided the first evidence that nerve growth factor is a diffusible substance. Nerve growth promoting tumors were implanted into developing embryos to determine whether the tumors stimulated growth by direct contact or by a diffusible substance.

Format: Articles

Subject: Experiments

Mother Teresa (1910-1997)

Mother Teresa, a Roman Catholic nun known for her charitable work and attention to the poor, was born 26 August 1910. The youngest child of Albanian parents Nikola and Drane Bojaxhiu, she was christened Agnes Gonxha Bojaxhiu and spent her early life in the place of her birth, present-day Skopje, in the Republic of Macedonia. In addition to her unwavering devotion to serve the sick and the poor, Mother Teresa firmly defended traditional Catholic teachings on more controversial issues, such as contraception and abortion.

Format: Articles

Subject: People, Religion, Reproduction

In the Womb: Identical Twins (2009), by National Geographic

National Geographic's documentary In the Womb: Identical Twins focuses on the prenatal development of human identical twins. Director Lorne Townend uses three-dimensional (3D) and four-dimensional (4D) ultrasound imaging and microscopy to depict twin development , genetic and epigenetic variations in the fetuses, and methods of fetal survival in the confines of the womb. Artist renditions of scientific data fill in areas of development inaccessible to the imaging tools.

Format: Articles

Subject: Outreach, Reproduction

"β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis" (2007), by Kyle A. Gurley, Jochen C. Rink, and Alejandro Sánchez Alvarado

Alejandro Sánchez Alvarado's laboratory group has employed molecular tools to investigate old questions about regeneration and as a result have identified some of the molecular mechanisms determining polarity. Recent work by his group has shown Wnt-β-catenin signaling determines whether a tail or a head will form during regeneration in planarians. This study was motivated by work Thomas Hunt Morgan conducted in the late nineteenth century.

Format: Articles

Subject: Experiments

Pregnancy Tests

Throughout history methods involving urine have been a popular way to test for pregnancy. Early ideas ranged from simply observing the color of a woman's urine to the notion that the urine of pregnant women contains special crystals or secretions. Indeed, pregnancy testing can be traced back to 1350 BCE in Ancient Egypt. A written document from the time describes a process in which a woman would urinate on wheat and barley seeds over several days and, depending on which plant grew, both the woman's pregnancy status and the sex of the fetus could be determined.

Format: Articles

Subject: Technologies, Reproduction

Meiosis in Humans

Meiosis, the process by which sexually-reproducing organisms generate gametes (sex cells), is an essential precondition for the normal formation of the embryo. As sexually reproducing, diploid, multicellular eukaryotes, humans rely on meiosis to serve a number of important functions, including the promotion of genetic diversity and the creation of proper conditions for reproductive success.

Format: Articles

Subject: Processes, Reproduction

Intracytoplasmic Sperm Injection

Intracytoplasmic Sperm Injection (ICSI) is an assisted reproductive technique (ART) initially developed by Dr. Gianpiero D. Palermo in 1993 to treat male infertility. It is most commonly used in conjunction with in vitro fertilization (IVF) or a less commonly used technique called zygote intrafallopian transfer (ZIFT). In natural fertilization, the sperm must penetrate the surface of the female egg, or oocyte.

Format: Articles

Subject: Technologies, Reproduction

Hysterectomy

A hysterectomy is the surgical removal of a woman's uterus. For many women, a hysterectomy comes as a solution to health problems as diverse as abnormal bleeding to reproductive cancers. First performed in the early 1800s, this procedure has evolved in terms of both technique and popularity. The first successful abdominal hysterectomy was performed by Ellis Burnham in Lowell, Massachusetts, in 1853, although earlier attempts were made in the 1840s.

Format: Articles

Subject: Technologies, Reproduction

Endoscopy

Endoscopy is a medical procedure that enables the viewing and biopsy of, and surgery on, internal tissues and organs. Endoscopic examinations are characterized by the introduction of a tube containing a series of lenses into the body through either an incision in the skin or a natural opening or cavity. During the mid-twentieth century, photographer Lennart Nilsson used endoscopes to capture the now-familiar images of embryos and fetuses.

Format: Articles

Subject: Technologies, Reproduction

Intrauterine Insemination

Intrauterine insemination (IUI), also known as artificial insemination, is one of the earliest and simplest assisted reproductive technologies (ART). With this technique, sperm from either a partner or donor (such as from a sperm bank) is inserted with a syringe into the woman's vagina during ovulation to increase the probability that fertilization will occur and lead to pregnancy.

Format: Articles

Subject: Technologies, Reproduction

Diprosopus (Craniofacial Duplication)

Diprosopus is a congenital defect also known as craniofacial duplication. The exact description of diprosopus refers to a fetus with a single trunk, normal limbs, and facial features that are duplicated to a certain degree. A less severe instance is when the nose is duplicated and the eyes are spaced far apart. In the most extreme instances, the entire face is duplicated, hence the name diprosopus, which is Greek for two-faced. Fetuses with diprosopus often also lack brains (anencephaly), have neural tube defects, or heart malformations.

Format: Articles

Subject: Disorders, Reproduction

Twin-to-Twin Transfusion Syndrome

Twin-to-Twin Transfusion Syndrome (TTTS) is a rare placental disease that can occur at any time during pregnancy involving identical twins. TTTS occurs when there is an unequal distribution of placental blood vessels between fetuses, which leads to a disproportionate supply of blood delivered. This unequal allocation of blood leads to developmental problems in both fetuses that can range in severity depending on the type, direction, and number of interconnected blood vessels.

Format: Articles

Subject: Disorders, Reproduction

Multi-Fetal Pregnancy

In humans, multi-fetal pregnancy occurs when a mother carries more than one fetus during the pregnancy. The most common multi-fetal pregnancy is twins, but mothers have given birth to up to eight children (octuplets) from a single pregnancy. Multiple fetusus can result from the release of multiple eggs or multiple ovulations, the splitting of a single fertilized egg, and fertility treatments such as in vitro fertilization (IVF) which involves the insertion of many fertilized eggs into the mother's uterus.

Format: Articles

Subject: Processes, Reproduction

Effect of Prenatal Alcohol Exposure on Radial Glial Cells

Prenatal alcohol (ethanol) exposure can have dramatic effects on the development of the central nervous system (CNS), including morphological abnormalities and an overall reduction in white matter of the brain. The impact of ethanol on neural stem cells such as radial glia (RG) has proven to be a significant cause of these defects, interfering with the creation and migration of neurons and glial cells during development.

Format: Articles

Subject: Disorders, Reproduction

Rock-Menkin Experiments

Dr. John Rock, a doctor of obstetrics and gynecology in Boston, and Miriam Menkin, Rock s hired lab technician, were the first researchers to fertilize a human egg outside of a human body in February of 1944. Their work was published on 4 August 1944 in an issue of Science in an article entitled "In Vitro Fertilization and Cleavage of Human Ovarian Eggs." This experiment marked the first time in history that a human embryo was produced outside of the human body, proving that in vitro fertilization was possible in humans.

Format: Articles

Subject: Experiments, Reproduction

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene was identified in 1989 by geneticist Lap-Chee Tsui and his research team as the gene associated with cystic fibrosis (CF). Tsui's research pinpointed the gene, some mutations to which cause CF, and it revealed the underlying disease mechanism. The CFTR gene encodes a protein in the cell membrane in epithelial tissues and affects multiple organ systems in the human body. Mutations in the CFTR gene cause dysfunctional regulation of cell electrolytes and water content.

Format: Articles

Subject: Disorders, Reproduction

Summerfield v. Superior Court [Brief] (1985)

Arizona joined the majority of states that recognized wrongful death claims on behalf of a viable fetus, regardless of whether the child was born alive or died in the womb by expanding the definition of "person" to include a viable fetus.

Format: Articles

Subject: Legal, Reproduction

Commonwealth v. Luceba Parker [Brief] (1845)

The Court settled the question left open from the case of Commonwealth v. Bangs that it must be proved a woman was "quick with child" in order for abortion prohibitions to have any effect in Massachusetts.

Format: Articles

Subject: Legal, Reproduction

Bonbrest v. Kotz [Brief] (1946)

This influential opinion was copied throughout the United States allowing civil actions and wrongful death claims on behalf of children who suffered injuries while a viable fetus. The case essentially overruled the opinion by Justice Oliver Wendell Holmes, Jr. in Dietrich v. Inhabitants of Northampton (1884). However, the ability to sue was usually limited in two ways: the fetus had to be viable, and a child had to be born alive to have a claim. These two restrictions have recently been removed in many jurisdictions.

Format: Articles

Subject: Legal, Reproduction

Davis v. Davis [Brief] (1992)

This case was the first of its kind to address questions of personhood in the context of in vitro fertilization of a human embryo. It laid a foundation for future cases to work from: specifically, this case established the importance of prior written agreements for disposition of frozen embryos. This was also the first court decision to borrow the word "pre-embryo" from bioethics to describe the in vitro embryo. This terminology has been copied by many states.

Format: Articles

Subject: Legal, Reproduction

Paretta v. Medical Offices for Human Reproduction [Brief] (2003)

The court decided a child of in vitro fertilization born with cystic fibrosis does not have the right to sue for wrongful life even in the presence of demonstrable acts of medical negligence because to allow such a case would grant the IVF child rights not possessed by naturally born children. The decision in Paretta has not been publicly tested in other jurisdictions.

Format: Articles

Subject: Legal, Reproduction

Role of Sonic Hedgehog (Shh) in Alcohol-Induced Craniofacial Abnormalities

Prenatal exposure to alcohol (ethanol) results in a continuum of physical and neurological developmental abnormalities that vary depending on the timing, duration, and degree of alcohol exposure. Heavy exposure during development may lead to the condition Fetal Alcohol Syndrome (FAS), characterized by growth deficits, neurological deficiencies and minor facial abnormalities. Alcohol is a known teratogen, an agent that causes birth defects and acts upon developing embryos through mechanisms that are not yet fully understood.

Format: Articles

Subject: Disorders

Mizuko Kuyo

Mizuko Kuyo is a Japanese Buddhist ceremony that focuses on a deceased fetus or stillborn child. This ceremony was originally developed to honor Jizo, a god believed to be responsible for transporting dead fetuses or children to the other world. The practice has become more popular in the last half century due to the growing number of abortions taking place and the particular views that Japanese Buddhists have about fetuses and abortion.

Format: Articles

Subject: Religion, Reproduction

Berman v. Allan (1979)

The Supreme Court of New Jersey decided the case of Berman v. Allan on 26 June 1979, brought by Shirley Berman and Paul Berman and their daughter Sharon Esther Berman against Ronald Allan and Michael Vincent Attardi, Shirley's physicians. The court dismissed the Bermans' claims for what they termed wrongful life of their daughter, but allowed them to claim compensation as a result of what was termed wrongful birth.

Format: Articles

Subject: Legal, Reproduction

The Cabinet of Frederik Ruysch

Frederik Ruysch's cabinet of curiosities, commonly referred to simply as the Cabinet, was a museum Ruysch created in the Netherlands in the late 160ss. The Cabinet filled a series of small houses that Ruysch rented in Amsterdam and contained over 2,000 specimens, including preserved fetuses and infants. The collection remained in Amsterdam until it was purchased by Tsar Peter the Great of Russia in 1717 and transferred to St. Petersburg, Russia.

Format: Articles

Subject: Organizations, Outreach