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Interspecies SCNT-derived Humanesque Blastocysts

Since the 1950s, scientists have developed interspecies blastocysts in laboratory settings, but not until the 1990s did proposals emerge to engineer interspecies blastocysts that contained human genetic or cellular material. Even if these embryos were not permitted to mature to fetal stages, their ethical and political status became debated within nations attempting to use them for research.

Format: Articles

Subject: Theories

Hartsoeker's Homunculus Sketch from Essai de Dioptrique

This embryology image is a pencil sketch by Nicolaas Hartsoeker, published as part of his 1694 French-language paper entitled Essai de Dioptrique, a semi-speculative work describing the sorts of new scientific observations that could be done using magnifying lenses. Dioptrique was published in Paris by the publishing house of Jean Anisson. The image depicts a curled up infant-like human, now referred to as a homunculus, inside the head of a sperm cell.

Format: Articles

Subject: Theories, Processes

Essay: The Cuvier-Geoffroy Debate

In 1830, a dispute erupted in the halls of lÕAcad mie des Sciences in Paris between the two most prominent anatomists of the nineteenth century. Georges Cuvier and tienne Geoffroy Saint-Hilaire, once friends and colleagues at the Paris Museum, became arch rivals after this historical episode. Like many important disputes in the history of science, this debate echoes several points of contrasts between the two thinkers.

Format: Essays and Theses

Subject: Theories

Epithelium

Frederik Ruysch, working in the Netherlands, introduced the term epithelia in the third volume of his Thesaurus Anatomicus in 1703. Ruysch created the term from the Greek epi, which means on top of, and thele, which means nipple, to describe the type of tissue he found when dissecting the lip of a cadaver. In the mid nineteenth century, anatomist Albrecht von Haller adopted the word epithelium, designating Ruysch's original terminology as the plural version. In modern science, epithelium is a type of animal tissue in which cells are packed into neatly arranged sheets.

Format: Articles

Subject: Theories, Processes

Mitochondrial DNA (mtDNA)

Mitochondrial DNA (mtDNA) is located outside the nucleus in the liquid portion of the cell (cytoplasm) inside cellular organelles called Mitochondria. Mitochondria are located in all complex or eukaryotic cells, including plant, animal, fungi, and single celled protists, which contain their own mtDNA genome. In animals with a backbone, or vertebrates, mtDNA is a double stranded, circular molecule that forms a circular genome, which ranges in size from sixteen to eighteen kilo-base pairs, depending on species. Each mitochondrion in a cell can have multiple copies of the mtDNA genome.

Format: Articles

Subject: Theories

Revive & Restore’s Woolly Mammoth Revival Project

In 2015, Revive & Restore launched the Woolly Mammoth Revival Project with a goal of engineering a creature with genes from the woolly mammoth and introducing it back into the tundra to combat climate change. Revive & Restore is a nonprofit in California that uses genome editing technologies to enhance conservation efforts in sometimes controversial ways.

Format: Articles

Subject: Theories, Technologies, Organizations, Ethics