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The China-US Study on the Prevention of Neural Tube Defects using Folic Acid (1999)
From 1993 to 1995 researchers led by Robert J. Berry from the US Centers for Disease Control headquartered in Atlanta, Georgia, and Zhu Li from Beijing Medical University in Beijing, China, conducted a collaborative study in China on the prevention of neural tube defects or NTDs using folic acid supplements. NTDs are birth defects in which openings in the spinal cord or the brain that occur during early development remain after birth. Neural-tube formation occurs in early pregnancy, often before a woman knows she is pregnant and therefore before she has begun taking prenatal vitamins.
“Sources of Human Psychological Differences: The Minnesota Study of Twins Reared Apart” (1990), by Thomas J. Bouchard Jr, David T. Lykken, Matthew McGue, Nancy L. Segal and Auke Tellegen
In 1990, Thomas J. Bouchard and his colleagues published the paper “Sources of Human Psychological Differences: The Minnesota Study of Twins Reared Apart” in Science Magazine. The paper described the results of a study initiated in 1979 on the development of twins raised in different environments. The scientists conducted their experiment at the University of Minnesota, in Minneapolis, Minnesota. The researchers physiologically and psychologically assessed monozygotic twins or triplets who were reared apart, comparing the similarity of those twins to twins who were reared together.
Ferguson v. City of Charleston (2001)
The US Supreme Court case Ferguson v. City of Charleston (2001) established that public hospitals couldn't legally drug test pregnant women without their consent when those women sought prenatal care at those hospitals. The court held that such searches violated the pregnant women's protections under the Fourth Amendment to the US Constitution. The decisions also indicated those circumstances that qualified as special needs exceptions to the Fourth Amendment, and it highlighted the extent to which pregnant women are sovereign individuals in the eyes of the Court. Ferguson v.
Hypertensive Disorders in Pregnancy (1978), by Leon Chesley
Leon Chesley published Hypertensive Disorders in Pregnancy in 1978 to outline major and common complications that occur during pregnancy and manifest in abnormally high blood pressures in pregnant women. The book was published by Appleton-Century-Crofts in New York, New York. Chesley compiled his book as a tool for practicing obstetricians and teachers.
Epidermal Growth Factor
Epidermal growth factor is a signaling molecule that stimulates the growth of epidermal tissues during development and throughout life. Stanley Cohen discovered epidermal growth factor (EGF) during studies of nerve growth factor as a side effect of other experiments. EGF stimulates tissue growth by initiating a variety of cellular mechanisms. This work led to the 1986 Nobel Prize in Physiology or Medicine awarded to Cohen and Rita Levi-Montalcini.
Effects of Prenatal Alcohol Exposure on Central Nervous System Development
Prenatal exposure to alcohol (ethanol) results in a continuum of physical, neurological, behavioral, and learning defects collectively grouped under the heading Fetal Alcohol Spectrum Disorder (FASD). Fetal Alcohol Syndrome (FAS) is part of this group and was first defined in 1973 as a condition characterized by pre- and postnatal growth deficiencies, facial abnormalities and defects of the central nervous system (CNS). The CNS is particularly vulnerable to the effects of ethanol during prenatal development.
Subject: Disorders, Reproduction
Twilight Sleep (Dammerschlaf) was a form
of childbirth first used in the early twentieth century in Germany in
which drugs caused women in labor to enter a state of sleep prior to
giving birth and awake from childbirth with no recollection of the
procedure. Prior to the early twentieth century, childbirth was
performed at home and women did not have anesthetics to alleviate the
pain of childbirth. In 1906, obstetricians Bernhardt Kronig and Karl
Gauss developed the twilight sleep method in 1906 to relieve the pain of
The Use of Morphine and Scopolamine to Induce Twilight Sleep
In 1907, researchers Bernhardt Kronig and Carl Gauss combined the drugs morphine and scopolamine to induce twilight sleep in women during childbirth. Physicians in the early twentieth century in Germany used twilight sleep, Dammerschlaf, to cause women to enter a state of consciousness in which they felt no pain and did not remember giving birth. Twilight sleep was associated with increased use of forceps during delivery, prolonged labor, and increased risk of infant suffocation.
"A Diffusible Agent of Mouse Sarcoma, Producing Hyperplasia of Sympathetic Ganglia and Hyperneurotization of Viscera in the Chick Embryo" (1953), by Rita Levi-Montalcini and Viktor Hamburger
"A Diffusible Agent of Mouse Sarcoma, Producing Hyperplasia of Sympathetic Ganglia and Hyperneurotization of Viscera in the Chick Embryo," by Rita Levi-Montalcini and Viktor Hamburger, appeared in 1953 in the Journal of Experimental Zoology. The paper provided the first evidence that nerve growth factor is a diffusible substance. Nerve growth promoting tumors were implanted into developing embryos to determine whether the tumors stimulated growth by direct contact or by a diffusible substance.
Mizuko Kuyo is a Japanese Buddhist ceremony that focuses on a deceased fetus or stillborn child. This ceremony was originally developed to honor Jizo, a god believed to be responsible for transporting dead fetuses or children to the other world. The practice has become more popular in the last half century due to the growing number of abortions taking place and the particular views that Japanese Buddhists have about fetuses and abortion.
Subject: Religion, Reproduction
Jane Marion Oppenheimer (1911-1966)
Jane Marion Oppenheimer, embryologist and historian of science and medicine, was born on 19 September 1911 in Philadelphia, Pennsylvania, to Sylvia Stern and James H. Oppenheimer. After studying zoology at Bryn Mawr College, Oppenheimer received her AB degree in 1932. Oppenheimer received her PhD in embryology at Yale University in 1935 and worked as a research fellow from 1935-1936. While at Yale she was influenced by the work of Ross Granville Harrison and John Spangler Nicholas, the latter of whom was Oppenheimer's PhD advisor.
The Eugenics Record Office at Cold Spring Harbor Laboratory (1910-1939)
From its founding in 1910 until it closed its doors in 1939, the Eugenics Record Office (ERO) at Cold Spring Harbor Laboratory in New York was the center of the American Eugenics Movement. Charles Davenport, a geneticist and biologist, founded the ERO, and served as its director until 1934. Under the direction of Davenport and his associate, superintendant Harry H. Laughlin, the influence of the ERO on science and public policy waxed during the early twentieth century until after World War II.
Subject: Organizations, Reproduction
"Limitations in Abortion Legislation: A Comparative Study" (2007), by Orli Lotan
Written by Orli Lotan on behalf of the Knesset (Israeli Parliament) Center for Research and Information, "Limitations in Abortion Legislation: A Comparative Study" (hereafter abbreviated "Legislation") examines abortion legislation in Israel, the US, Canada, and a number of European countries. The study also acknowledges the medical, moral, ethical, and religious implications of abortion and the impact of such legislation on society in each country.
Subject: Publications, Legal, Reproduction
Kurt Benirschke (1924-)
Kurt Benirschke studied cells, placentas, and endangered species in Germany and the US during the twentieth century. Benirschke was professor at the University of California in San Diego, California, and a director of the research department at the San Diego Zoo in San Diego, California. He also helped form the research department of the San Diego Zoo and its sister organization, the Center for Reproduction of Endangered Species.
The term morphogenesis generally refers to the processes by which order is created in the developing organism. This order is achieved as differentiated cells carefully organize into tissues, organs, organ systems, and ultimately the organism as a whole. Questions centered on morphogenesis have aimed to uncover the mechanisms responsible for this organization, and developmental biology textbooks have identified morphogenesis as one of the main challenges in the field. The concept of morphogenesis is intertwined with those of differentiation, growth, and reproduction.
The Roslin Institute (1993- )
The Roslin Institute was established in 1993 in the village of Roslin, Scotland, as an independent research center by the Biotechnology and Biological Sciences Research Council (BBSRC), and as of 2014 is part of the University of Edinburgh in Edinburgh, Scotland. Researchers at the Roslin Institute cloned the Dolly the sheep in 1996. According to the Roslin Institute, Dolly was the first mammal to develop into an adult from the transfer of the nucleus of an adult sheep cell into an ovum with the nucleus removed.
“Causes of Death Among Stillbirths” (2011), by Stillbirth Collaborative Research Network Writing Group
In December 2011, the Stillbirth Collaborative Research Network, or SCRN, published the article “Causes of Death Among Stillbirths” in The Journal of the American Medical Association. The authors of the article investigate the causes of stillbirth and possible reasons for the racial, ethnic, and geographic disparities in stillbirth rates. According to the Centers for Disease Control and Prevention, or CDC, stillbirth is the death of a fetus at twenty or more weeks during pregnancy.
Hermaphrodites and the Medical Invention of Sex (1998), by Alice Domurat Dreger
Hermaphrodites and the Medical Invention of Sex, by historian of science Alice Domurat Dreger, was published in 1998 by Harvard University Press. In the book, Dreger describes how many doctors and scientists treated human hermaphrodites from the late nineteenth century to the early twentieth century. She states that during this time period, many physicians and scientists struggled to determine the nature sex, and to support a classification of sex as male or female, many physicians and scientists resorted to viewing a person's gonads for identification of his or her sex.
Subject: Publications, Theories, Disorders
Alan Mathison Turing (1912-1954)
Alan Mathison Turing was a British mathematician and computer scientist who lived in the early twentieth century. Among important contributions in the field of mathematics, computer science, and philosophy, he developed a mathematical model of morphogenesis. This model describing biological growth became fundamental for research on the process of embryo development.
Effects of Prenatal Alcohol Exposure on Basal Ganglia Development
Prenatal exposure to alcohol (ethanol) in human and animal models results in a range of alcohol-induced developmental defects. In humans, those collective birth defects are called Fetal Alcohol Spectrum Disorders, with the most severe manifestation being Fetal Alcohol Syndrome (FAS). FAS is defined by pre- and post-natal growth retardation, minor facial abnormalities, and deficiencies in the central nervous system (CNS). The basal ganglia, one of the central nervous system components, are affected by exposure to ethanol during development.
Subject: Disorders, Reproduction
Exchange Transfusion for Jaundiced Newborns in the United States
Exchange transfusion is the replacement of blood from newborn infants with elevated bilirubin level in their blood stream with donor blood containing normal bilirubin levels. Newborn infants that experience jaundice, the yellowing of the skin and eyes, have a buildup of bilirubin, a chemical that occurs during red blood cell breakdown, or hemolysis. Exchange transfusion is a therapy developed throughout the 1940s by Louis Diamond and a group of surgeons at the Children’s Medical Center in Boston, Massachusetts.
Shoukhrat Mitalipov and Masahito Tachibana's Mitochondrial Gene Replacement Therapy Technique
In 2009, Shoukhrat Mitalipov, Masahito Tachibana, and their team of researchers developed the technology of mitochondrial gene replacement therapy to prevent the transmission of a mitochondrial disease from mother to offspring in primates. Mitochondria contain some of the body's genetic material, called mitochondrial DNA. Occasionally, the mitochondrial DNA possesses mutations.
Texas Medical Providers Performing Abortion Services v. Lakey (2012)
In the 2012 case Texas Medical Providers Performing Abortion Services v. David Lakey, a US appeals court ruled as constitutional a Texas law that required abortion providers in the state to show women receiving abortions the ultrasound images of their fetuses. The law also required providers to describe the sounds of the fetuses' nascent hearts. In doing so, the court set precedent that ultrasound readings are necessary medical information for pregnant women seeking abortions, increasing the wait-period for women seeking abortions.
Carol Downer (1933– )
Carol Downer was a reproductive health and abortion rights activist in the twentieth and twenty-first centuries in the US and other countries. During the late 1960s, many women reported knowing little about female anatomy and receiving little information from their physicians. Downer advocated for women’s reproductive anatomy education and encouraged women to not rely on the intervention of a medical doctor for all reproductive issues.
Whitner v. South Carolina (1997)
In the case Whitner v. South Carolina in 1997, the South Carolina State Supreme Court defined the concept of a child to include viable fetuses. This allowed grounds for prosecution of a pregnant womanÕs prenatal activity if those activities endangered or could potentially endanger the fetus within her. The case brought the issue of fetal rights versus pregnant womenÕs rights to light.
Subject: Legal, Reproduction