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Role of Sonic Hedgehog (Shh) in Alcohol-Induced Craniofacial Abnormalities

Prenatal exposure to alcohol (ethanol) results in a continuum of physical and neurological developmental abnormalities that vary depending on the timing, duration, and degree of alcohol exposure. Heavy exposure during development may lead to the condition Fetal Alcohol Syndrome (FAS), characterized by growth deficits, neurological deficiencies and minor facial abnormalities. Alcohol is a known teratogen, an agent that causes birth defects and acts upon developing embryos through mechanisms that are not yet fully understood.

Format: Articles

Subject: Disorders

Mizuko Kuyo

Mizuko Kuyo is a Japanese Buddhist ceremony that focuses on a deceased fetus or stillborn child. This ceremony was originally developed to honor Jizo, a god believed to be responsible for transporting dead fetuses or children to the other world. The practice has become more popular in the last half century due to the growing number of abortions taking place and the particular views that Japanese Buddhists have about fetuses and abortion.

Format: Articles

Subject: Religion, Reproduction

Planned Parenthood v. Casey (1992)

Almost ten years after the landmark decision in Roe v. Wade (1973) the battle over abortion was still being waged. The reproductive rights of women in the United States were being challenged yet again by the Pennsylvania Abortion Control Act of 1982. The act was comprised of four provisions that restricted the fundamental right a woman had to obtaining an abortion, as established in Roe v. Wade. The four provisions included spousal notification, information disclosure, a twenty-four hour waiting period, and parental consent for minors.

Format: Articles

Subject: Legal, Reproduction

The Cabinet of Frederik Ruysch

Frederik Ruysch's cabinet of curiosities, commonly referred to simply as the Cabinet, was a museum Ruysch created in the Netherlands in the late 160ss. The Cabinet filled a series of small houses that Ruysch rented in Amsterdam and contained over 2,000 specimens, including preserved fetuses and infants. The collection remained in Amsterdam until it was purchased by Tsar Peter the Great of Russia in 1717 and transferred to St. Petersburg, Russia.

Format: Articles

Subject: Organizations, Outreach

Pope Sixtus V (1520-1590)

Known for dropping a long-held distinction in the Catholic Church between the animated and unanimated fetus, Felice Peretti was born in Grottamare, Italy, in 1521, son of a Dalmatian gardener. In his early years, Peretti worked as a swineherd, but soon became involved in the local Minorite convent in Montalto, where he served as a novice at the age of twelve. He went on to study in Montalto, Ferrara, and Bologna, continuing his devotion to religious life, and in 1547 Peretti was ordained as priest in the city of Siena.

Format: Articles

Subject: People, Religion, Reproduction

Girolamo Fabrici (1537-1619)

Girolamo Fabrici, known as Hieronymus Fabricius in Latin, was given the surname Aquapendente from the city where he was born, near Orvieto, Italy. Born in 1533, Fabrici was the eldest son of a respected noble family, whose coat of arms appears as an illustration in the title page of Fabrici's book on embryology, De formato foetu. Little is known of Fabrici's parents. His father is recorded as Fabricio, and Fabrici is said to have been named for his paternal grandfather.

Format: Articles

Subject: People

Birth without Violence (1975), by Frederick Leboyer

In Birth without Violence (1975), French obstetrician Frederick Leboyer describes in poetic form the possible perceptions and feelings of embryos and fetuses before, during, and after birth. His work has helped to promote a gentler and more sensitive birthing method with the goal of easing the newborn's transition from the womb to the outside world. Leboyer's birthing method influenced later birth techniques such as water birth and unassisted childbirth.

Format: Articles

Subject: Publications, Reproduction

Arizona State University Embryo Project Photograph Collections

In the 1970s Stanford University Embryologist Harold Heath sent a box of photographs to Frederick B. Churchill, who was a Professor in the History and Philosophy of Science Department at Indiana University. Heath was born in Indiana, he knew that Churchill was the leading historian of embryology, and he wanted his photographs to be used and therefore wanted them to be housed somewhere with an interest in the history of biology. Heath made it clear that he was donating the photographs for use by scholars and the public.

Format: Articles

Subject: Outreach

Quickening

Quickening, the point at which a pregnant woman can first feel the movements of the growing embryo or fetus, has long been considered a pivotal moment in pregnancy. Over time, this experience has been used in a variety of contexts, ranging from representing the point of ensoulment to determining whether an abortion was legal to indicating the gender of the unborn baby; philosophy, theology, and law all address the idea of quickening in detail. Beginning with Aristotle, quickening divided the developmental stages of embryo and fetus.

Format: Articles

Subject: Processes, Ethics, Reproduction

"Effraenatam" (1588), by Pope Sixtus V

"Effraenatam," the brain-child of Pope Sixtus V, was released as a papal bull in the year 1588. Papal bulls are formal declarations issued by the pope of the Roman Catholic Church and are named for their authenticating leaden seals (bullas). This particular document became famous for its official forbiddance of all procured abortions. "Effraenatam," meaning "without restraint," is often regarded as a specific response to increasing rates of prostitution and procured abortions in the Papal States, though this is not discussed in the actual document.

Format: Articles

Subject: Religion, Reproduction

Birth Control or the Limitation of Offspring (1936), by William J. Robinson

Birth Control or the Limitation of Offspring was written by American eugenics and birth control advocate William J. Robinson. First published in 1916, the final edition (forty-eighth) was published in 1936, the same year that Robinson died. As a medical doctor and author, Robinson used his influence to promote propaganda for "fewer and better babies," by focusing on contraception. Even Margaret Sanger, another prominent eugenics and birth control advocate, took great interest in this book. Robinson had three goals in mind when writing Birth Control.

Format: Articles

Subject: Publications, Reproduction

Turpin v. Sortini (1982)

The Supreme Court of California reversed the Superior Court of Fresno County's decision to dismiss the Turpins' claims in the case Turpin v. Sortini on 3 May 1982. The case was based upon a wrongful life claim, in which a disabled child sues physicians for neglecting to inform its parents of potential genetic defects, resulting in harm to the child when it is born. The Turpin case determined tha a physician could be liable for failing to inform parents of potential birth defects in the fetus.

Format: Articles

Subject: Legal, Reproduction

Advanced Cell Technology, Inc.

Advanced Cell Technology, Inc. (ACT) is a biotechnology company that uses stem cell technology to develop novel therapies in the field of regenerative medicine. Formed in 1994, ACT grew from a small agricultural cloning research facility located in Worcester, Massachusetts, into a multi-locational corporation involved in using both human embryonic stem cells (hESC) and human adult stem cells as well as animal cells for therapeutic innovations.

Format: Articles

Subject: Organizations, Reproduction

Rh Incompatibility in Pregnancy

Rh incompatibility occurs when a pregnant woman whose blood type is Rh-negative is exposed to Rh-positive blood from her fetus, leading to the mother s development of Rh antibodies. These antibodies have the potential to cross the placenta and attach to fetal red blood cells, resulting in hemolysis, or destruction of the fetus 's red blood cells. This causes the fetus to become anemic, which can lead to hemolytic disease of the newborn. In severe cases, an intrauterine blood transfusion for the fetus may be required to correct the anemia.

Format: Articles

Subject: Processes, Disorders, Reproduction

Amniocentesis Prior to 1980

The extraembryonic membranes that surround and originate from the embryos of vertebrates such as birds, reptiles, and mammals are crucial to their development. They are integral to increasing the surface area of the uterus, forming the chorion (which in turn produces the placenta) and the amnion, respectively. The amnion will ultimately surround the embryo in a fluid-filled amniotic cavity. This amniotic fluid, which cushions and protects the fetus and helps prevent the onset of labor, is sampled in amniocentesis to screen for genetic diseases.

Format: Articles

Subject: Processes, Reproduction

Neural Tube Defects (NTD): Folic Acid and Pregnancy

In the US, one in 1000 births is affected by neural tube defects (NTD). A neural tube defect is a birth defect involving the malformation of body features associated with the brain and spinal cord. An NTD originates from and is characterized by incomplete closure of the neural tube, which is an organizer and precursor of the central nervous system.

Format: Articles

Subject: Disorders, Reproduction

Francis Galton (1822-1911)

Sir Francis Galton was a British science writer and amateur researcher of the late nineteenth century. He contributed greatly to the fields of statistics, experimental psychology and biometry. In the history of biology, Galton is widely regarded as the originator of the early twentieth century eugenics movement. Galton published influential writings on nature versus nurture in human personality traits, developed a family study method to identify possible inherited traits, and devised laws of genetic inheritance prior to the rediscovery of Gregor Mendel's work.

Format: Articles

Subject: People, Reproduction

The Comstock Law (1873)

The Comstock Law was a controversial law because it limited the reproductive rights of women and violated every person's right to privacy. This federal law was the beginning of a long fight over the reproductive rights of women which is still being waged. Reproductive rights are important to embryology because they lead to the discussions regarding the morality of abortion, contraceptives, and ultimately the moral status of the embryo.

Format: Articles

Subject: Legal, Reproduction

Richard Woltereck (1877-1944)

Richard Woltereck was a German zoologist and hydrobiologist who studied aquatic animals and extended the concept of Reaktionsnorm (norm of reaction) to the study of genetics. He also provided some of the first experimental evidence for the early twentieth-century embryological theory of heredity known as cytoplasmic inheritance. Through experiments on the water flea, Daphnia, Woltereck investigated whether variation produced by environmental impacts on development could play a role in heredity and evolution.

Format: Articles

Subject: People

Jan Swammerdam (1637-1680)

Jan Swammerdam, known as the founder of the preformation theory based on his extensive research on insect development, was born on 12 February 1637 in Amsterdam, the Netherlands, to Baertje Jans Corvers and Jan Jacobszoon Swammerdam. He began medical school on 11 October 1661 at the University of Leiden. A few of his classmates included Regnier de Graaf, Frederik Ruysch, Niels Stensen (Nicolaus Steno), and Robertus Padtbrugge. Padtbrugge would later join the East India Company and send Swammerdam exotic animals.

Format: Articles

Subject: People

Eisenstadt v. Baird (1972)

Prior to 1971, women had some difficulty obtaining contraceptive materials due to a law prohibiting the distribution of contraceptives by anyone other than a registered physician or registered pharmacist. This limited access to contraceptives had an impact on women's reproductive rights and it was the Supreme Court case Eisenstadt v. Baird (1972) that helped bring the issue into the public spotlight. It demonstrated that women's bodies have reproductive as well as anatomical functions, and that the right to privacy extends to those reproductive functions.

Format: Articles

Subject: Legal, Reproduction

Richard Woltereck's Concept of Reaktionsnorm

Richard Woltereck first described the concept of Reaktionsnorm (norm of reaction) in his 1909 paper 'Weitere experimentelle Untersuchungen uber Art-veranderung, speziell uber das Wesen quantitativer Artunterschiede bei Daphniden' ('Further investigations of type variation, specifically concerning the nature of quantitative differences between varieties of Daphnia'). This concept refers to the ways in which the environment can alter the development of an organism, and its adult characteristics.

Format: Articles

Subject: Theories

Alexis Carrel's Immortal Chick Heart Tissue Cultures (1912-1946)

In an effort to develop tissue culture techniques for long-term tissue cultivation, French surgeon and biologist Alexis Carrel, and his associates, produced and maintained a series of chick heart tissue cultures at the Rockefeller Institute in New York City. From 1912 to 1946, this series of chick heart tissue cultures remained alive and dividing. Since the duration of this culture greatly exceeded the normal chick life span, the cells were deemed immortal.

Format: Articles

Subject: Experiments

Parasitic Twins

Parasitic twins, a specific type of conjoined twins, occurs when one twin ceases development during gestation and becomes vestigial to the fully formed dominant twin, called the autositic twin. The underdeveloped twin is called parasitic because it is only partially formed, is not functional, or is wholly dependent on the autositic twin.

Format: Articles

Subject: Disorders, Reproduction

Effects of Prenatal Alcohol Exposure on Basal Ganglia Development

Prenatal exposure to alcohol (ethanol) in human and animal models results in a range of alcohol-induced developmental defects. In humans, those collective birth defects are called Fetal Alcohol Spectrum Disorders, with the most severe manifestation being Fetal Alcohol Syndrome (FAS). FAS is defined by pre- and post-natal growth retardation, minor facial abnormalities, and deficiencies in the central nervous system (CNS). The basal ganglia, one of the central nervous system components, are affected by exposure to ethanol during development.

Format: Articles

Subject: Disorders, Reproduction