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The Discovery of p53 Protein
The p53 protein acts as a pivotal suppressor of inappropriate cell proliferation. By initiating suppressive effects through induction of apoptosis, cell senescence, or transient cell-cycle arrest, p53 plays an important role in cancer suppression, developmental regulation, and aging. Its discovery in 1979 was a product of research into viral etiology and the immunology of cancer. The p53 protein was first identified in a study of the role of viruses in cancer through its ability to form a complex with viral tumor antigens.
Format: Articles
Subject: Experiments
"Alternative Sources of Human Pluripotent Stem Cells" (2005), by Leon Kass and the President’s Council on Bioethics
Human pluripotent stem cells are valued for their potential to form numerous specialized cells and for their longevity. In the US, where a portion of the population is opposed to destruction of human embryos to obtain stem cells, what avenues are open to scientists for obtaining pluripotent cells that do not offend the moral sensibilities of a significant number of citizens?
Format: Articles
Subject: Publications, Ethics
St. George Jackson Mivart (1827-1900)
St. George Jackson Mivart studied animals and worked in England during the nineteenth century. He also proposed a theory of organismal development that he called individuation, and he critiqued Charles Darwin's argument for evolution by natural selection. His work on prosimians, a group of primates excluding apes and monkeys, helped scientists better investigate the Primate group.
Format: Articles
Subject: People
Gustav Jacob Born (1851-1900)
Gustav Jacob Born was an experimental embryologist whose original work with amphibians served as the platform for his wax-plate method of embryo modeling, heteroblastic (different tissues) and xenoplastic (similar species) transplantation methods, environmental influences on sex ratio studies, and proposed function of the corpus luteum. He was born 22 April 1851 in Kempen, Prussia, but his family moved to the larger city of Görlitz within a year after Born's birth. His father was Marcus Born, a physician and public health officer who practiced in the town of Görlitz.
Format: Articles
Subject: People
Hans Asperger (1906-1980)
Hans Asperger studied mental abnormalities in children in
Vienna, Austria, in the early twentieth century. Asperger was one of
the early researchers who studied the syndrome that was later named
after him, Asperger's Syndrome. Asperger described the syndrome in
his 1944 publication Die Autistischen Psychopathen im
Kindesalter (Autistic Psychopathy in Childhood). At that time,
the syndrome was called autistic psychopathy, and Asperger noted
that characteristics of the syndrome included lack of sympathy,
Format: Articles
Subject: People
Twilight Sleep
Twilight Sleep (Dammerschlaf) was a form
of childbirth first used in the early twentieth century in Germany in
which drugs caused women in labor to enter a state of sleep prior to
giving birth and awake from childbirth with no recollection of the
procedure. Prior to the early twentieth century, childbirth was
performed at home and women did not have anesthetics to alleviate the
pain of childbirth. In 1906, obstetricians Bernhardt Kronig and Karl
Gauss developed the twilight sleep method in 1906 to relieve the pain of
Format: Articles
Subject: Theories
Boston Women’s Health Book Collective, later Our Bodies Ourselves (1969–)
The Boston Women’s Health Book Collective was a women’s health organization headquartered in Boston, Massachusetts, that published the informational book Our Bodies Ourselves, which sold over 4.5 million copies. Initially called the Doctor’s Group, the Collective formed in response to the insufficiency of women-specific health information during the late 1960s and early 1970s. Members of the organization participated in the women’s liberation movement in Boston, Massachusetts, and conducted research on women’s health using resources such as medical textbooks.
Format: Articles
Subject: Organizations
Barbara Seaman (1935–2008)
Barbara Seaman was a writer, investigator, and advocate for female healthcare rights during the twentieth century in the United States. Seaman’s work addressed the gendered prejudice she observed in the US healthcare system and argued that women of the 1960s lacked the proper tools to make informed decisions about pregnancy care, breastfeeding, childbirth, and contraception. Seaman wrote the book The Doctor’s Case Against the Pill in 1969 to expose the dangers in prescribing and consuming high doses of estrogen in the form of birth control.
Format: Articles
Subject: People
Ovarian Hyperstimulation Syndrome (OHSS) Caused by Fertility Treatment
Ovarian hyperstimulation syndrome, abbreviated OHSS, is an atypical reaction that women may experience in response to excessive hormones, and often occurs during fertility treatments. OHSS is typically triggered by hormonal medications designed to mature eggs in the ovaries, which can cause blood vessels within the ovaries to leak fluid. Sometimes that can lead to painful tenderness or swelling. In severe cases of OHSS, that fluid can leak into the abdominal cavity in large amounts, causing vomiting, blood clots, and severe pain.
Format: Articles
Subject: Reproduction
Theophilus Shickel Painter (1889-1969)
Theophilus Shickel Painter studied the structure and
function of chromosomes in the US during in the early to mid-twentieth century. Painter worked at
the University of Texas at Austin in Austin, Texas. In the 1920s
and 1930s, Painter studied the chromosomes of the salivary gland
giant chromosomes of the fruit fly (Drosophila
melanogaster), with Hermann J. Muller. Muller and Painter
studied the ability of X-rays to cause changes in the chromosomes
of fruit flies. Painter also studied chromosomes in mammals.
Format: Articles
Subject: People
Calvin Bridges’ Experiments on Nondisjunction as Evidence for the Chromosome Theory of Heredity (1913-1916)
From 1913 to 1916, Calvin Bridges performed experiments that indicated genes are found on chromosomes. His experiments were a part of his doctoral thesis advised by Thomas Hunt Morgan in New York, New York. In his experiments, Bridges studied Drosophila, the common fruit fly, and by doing so showed that a process called nondisjunction caused chromosomes, under some circumstances, to fail to separate when forming sperm and egg cells. Nondisjunction, as described by Bridges, caused sperm or egg cells to contain abnormal amounts of chromosomes.
Format: Articles
Subject: Experiments, Publications
Birth Control or the Limitation of Offspring (1936), by William J. Robinson
Birth Control or the Limitation of Offspring was written by American eugenics and birth control advocate William J. Robinson. First published in 1916, the final edition (forty-eighth) was published in 1936, the same year that Robinson died. As a medical doctor and author, Robinson used his influence to promote propaganda for "fewer and better babies," by focusing on contraception. Even Margaret Sanger, another prominent eugenics and birth control advocate, took great interest in this book. Robinson had three goals in mind when writing Birth Control.
Format: Articles
Subject: Publications, Reproduction
“Reproductive Injustice: Racial and Gender Discrimination in U.S. Healthcare” (2014), by the Center for Reproductive Rights, the National Latina Institute for Reproductive Health, and SisterSong Women of Color Reproductive Justice Collective
In 2014, the Center for Reproductive Rights, SisterSong Women of Color Reproductive Justice Collective, and the National Latina Institute for Reproductive Health released a co-authored report titled “Reproductive Injustice: Racial and Gender Discrimination in U.S. Healthcare,” hereafter “Reproductive Injustice.” In “Reproductive Injustice,” the organizations evaluate trends in the US federal system concerning racial and gender discrimination in sexual and reproductive healthcare.
Format: Articles
Subject: Publications, Organizations, Outreach, Legal
Title X Family Planning Program (1970–1977)
The Family Planning Services and Public Research Act of 1970, often called Title X Family Planning Program, is a US federal law that provides federal funding for family planning services to low income or uninsured families. The US federal government passed the law, Public Law 91-572, in 1970 as an amendment to the Public Health Services Act of 1944. The Act created the Office of Population Affairs (OPA) under the Secretary of Health, Education, and Welfare (here called the Secretary).
Format: Articles
Subject: Reproduction, Legal
David Starr Jordan (1851-1931)
David Starr Jordan studied fish and promoted eugenics in the US during the late nineteenth and early twentieth centuries. In his work, he embraced Charles Darwin s theory of evolution and described the importance of embryology in tracing phylogenic relationships. In 1891, he became the president of Stanford University in Stanford, California. Jordan condemned war and promoted conservationist causes for the California wilderness, and he advocated for the eugenic sterilization of thousands of Americans.
Format: Articles
Subject: People, Reproduction
Orchiopexy
Orchiopexy, also known as orchidopexy, is a surgical technique that can correct cryptorchidism and was successfully performed for one of the first times in 1877 in Scotland. Cryptorchidism, a condition where one or both of the testicles fail to descend before birth, is one of the most common male genital birth defects, affecting approximately 2 to 8 percent of full-term male infants, and around 33 percent of premature infants. Typically in the womb, male testes form within the abdomen, then descend into the scrotal area between twenty-five to thirty-five weeks’ gestation.
Format: Articles
Subject: Technologies, Disorders, Reproduction
“Beyond Menstrual Hygiene: Addressing Vaginal Bleeding Throughout the Life Course in LMICs” (2017), by Marni Sommer, Penelope A. Phillips-Howard, Therese Mahon, Sasha Zients, Meredith Jones, and Bethany A. Caruso
In “Beyond Menstrual Hygiene: Addressing Vaginal Bleeding Throughout the Life Course in LMICs,” hereafter “Beyond Menstrual Hygiene,” Marni Sommer, Penelope A. Phillips-Howard, Therese Mahon, Sasha Zients, Meredith Jones, and Bethany A. Caruso explored the barriers women experience in managing menstruation and other forms of vaginal bleeding in low and middle-income countries, which the researchers abbreviate to LMICs. The medical journal British Medical Journal Global Health published the article on 27 July 2017.
Format: Articles
Subject: Reproduction, Publications
Margaret Higgins Sanger (1879-1966)
Margaret Higgins Sanger advocated for birth control in the United States and Europe during the late nineteenth and early twentieth centuries. Although people used contraceptives prior to the twentieth century, in the US the 1873 Comstock Act made the distribution of information relating to the use of contraceptives illegal, and similar state-level Comstock laws also classified discussion and dissemination of contraceptives as illegal.
Format: Articles
Subject: People, Reproductive Health Arizona, Reproduction, Outreach
Seed Collection and Plant Genetic Diversity, 1900-1979
Farmers have long relied on genetic diversity to breed new crops, but in the early 1900s scientists began to study the importance of plant genetic diversity for agriculture. Scientists realized that seed crops could be systematically bred with their wild relatives to incorporate specific genetic traits or to produce hybrids for more productive crop yields.
Format: Articles
Subject: Organizations
"On the Origin of Mitosing Cells" (1967), by Lynn Sagan
On the Origin of Mitosing Cells by Lynn Sagan appeared in the March 1967 edition of the Journal of Theoretical Biology. At the time the article was published, Lynn Sagan had divorced astronomer Carl Sagan, but kept his last name. Later, she remarried and changed her name to Lynn Margulis, and will be referred to as such throughout this article. In her 1967 article, Margulis develops a theory for the origin of complex cells that have enclosed nuclei, called eukaryotic cells.
Format: Articles
Subject: Publications, Theories
Keith Henry Stockman Campbell (1954-2012)
Keith Henry Stockman Campbell studied embryo growth and cell differentiation during the twentieth and twenty-first centuries in the UK. In 1995, Campbell and his scientific team used cells grown and differentiated in a laboratory to clone sheep for the first time. They named these two sheep Megan and Morag. Campbell and his team also cloned a sheep from adult cells in 1996, which they named Dolly. Dolly was the first mammal cloned from specialized adult (somatic) cells with the technique of somatic cell nuclear transfer (SCNT).
Format: Articles
Subject: People
MicroSort
"MicroSort, developed in 1990 by the Genetics and IVF Institute, is a form of pre-conception sex selection technology for humans. Laboratories located around the world use MicroSort technology to help couples increase their chances of conceiving a child of their desired sex. MicroSort separates male sperm cells based on which sex chromosome they contain, which results in separated semen samples that contain a higher percentage of sperm cells that carry the same sex chromosome.
Format: Articles
Subject: Technologies
The Mustard Operation
The Mustard Operation is a surgical technique to correct a heart condition called the transposition of the great arteries (TGA). TGA is a birth defect in which the placement of the two arteries, the pulmonary artery, which supplies deoxygenated blood to the lungs, and the aorta, which takes oxygenated blood to the body are switched. William Thornton Mustard developed the operation later named for him and in 1963 operated on an infant with TGA, and ameliorated the condition, at the Hospital for Sick Children in Toronto, Canada.
Format: Articles
Subject: Technologies, Disorders
Charles Otis Whitman (1842-1910)
Charles Otis Whitman was an extremely curious and driven researcher who was not content to limit himself to one field of expertise. Among the fields of study to which he made significant contributions were: embryology; morphology, or the form of living organisms and the relationships between their structures; natural history; and behavior.
Format: Articles
Subject: People
Post-Coital Oral Emergency Contraception
Post-coital oral emergency contraception is used for the prevention of pregnancy after intercourse. The contraception comes in the form of pills, often collectively referred to as morning-after pills. Post-coital use of morning-after pills separates them from traditional contraception which is either a continual preventative process, such as the birth control pill, or used during intercourse, such as condoms.
Format: Articles
Subject: Processes, Reproduction