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“The Intergenerational Effects of Fetal Programming: Non-genomic Mechanisms for the Inheritance of Low Birth Weight and Cardiovascular Risk” (2004), by Amanda J. Drake and Brian R. Walker

In 2004, Amanda J. Drake and Brian R. Walker published “The Intergenerational Effects of Fetal Programming: Non-genomic Mechanisms for the Inheritance of Low Birth Weight and Cardiovascular Risk,” hereafter, “The Intergenerational Effects,” in the Journal of Endocrinology. In their article, the authors assert that cardiovascular disease may develop via fetal programming, which is when a certain event occurring during a critical point of pregnancy affects the fetus long after birth.

Format: Articles

Subject: Publications, Theories, Reproduction

Aristotle (384-322 BCE)

Aristotle studied developing organisms, among other things, in ancient Greece, and his writings shaped Western philosophy and natural science for greater than two thousand years. He spent much of his life in Greece and studied with Plato at Plato's Academy in Athens, where he later established his own school called the Lyceum. Aristotle wrote greater than 150 treatises on subjects ranging from aesthetics, politics, ethics, and natural philosophy, which include physics and biology. Less than fifty of Aristotle's treatises persisted into the twenty-first century.

Format: Articles

Subject: People

The Y-Chromosome in Animals

The Y-chromosome is one of a pair of chromosomes that determine the genetic sex of individuals in mammals, some insects, and some plants. In the nineteenth and twentieth centuries, the development of new microscopic and molecular techniques, including DNA sequencing, enabled scientists to confirm the hypothesis that chromosomes determine the sex of developing organisms. In an adult organism, the genes on the Y-chromosome help produce the male gamete, the sperm cell. Beginning in the 1980s, many studies of human populations used the Y-chromosome gene sequences to trace paternal lineages.

Format: Articles

Subject: Reproduction, Theories

Breast Augmentation Techniques

Breast augmentation involves the use of implants or fat tissue to increase patient breast size. As of 2019, breast augmentation is the most popular surgical cosmetic procedure in the United States, with annual patient numbers increasing by 41 percent since the year 2000. Since the first documented breast augmentation by surgeon Vincenz Czerny in 1895, and later the invention of the silicone breast implant in 1963, surgeons have developed the procedure into its own specialized field of surgery, creating various operating techniques for different results.

Format: Articles

Subject: Technologies, Processes, Reproduction, Ethics

Felix Anton Dohrn

Felix Anton Dohrn is best remembered as the founder of the Stazione Zoologica di Napoli, the world' s first permanent laboratory devoted to the study of marine organisms. Dohrn was born on 29 December 1840 in Stettin, Pomerania (now Poland), to a wealthy merchant family. Dohrn's paternal grandfather, Heinrich, trained as a surgeon and then established a sugar refinery, while Dohrn's father, Carl August Dohrn, who inherited the family business, became interested in natural history through Alexander von Humboldt, a family friend.

Format: Articles

Subject: People

Title X Family Planning Program (1970–1977)

The Family Planning Services and Public Research Act of 1970, often called Title X Family Planning Program, is a US federal law that provides federal funding for family planning services to low income or uninsured families. The US federal government passed the law, Public Law 91-572, in 1970 as an amendment to the Public Health Services Act of 1944. The Act created the Office of Population Affairs (OPA) under the Secretary of Health, Education, and Welfare (here called the Secretary).

Format: Articles

Subject: Reproduction, Legal

Royal College of Obstetricians and Gynaecologists (1929–1970)

Starting in 1929, the Royal College of Obstetricians and Gynaecologists was a professional association of physicians in the UK that aimed to improve the care of women in childbirth through training and education and to establish obstetrics and gynecology as a medical specialty. The Royal College of Obstetricians and Gynaecologists has contributed to women’s reproductive health by fostering research, establishing standards for physicians specializing in obstetrics and gynecology, and influencing legislation.

Format: Articles

Subject: Organizations

"Testing the Kin Selection Theory: Who Controls the Investments?" from The Ants (1990), by Bert Hölldobler and Edward O. Wilson

In “Testing the Kin Selection Theory: Who Controls the Investments?” Bert Hölldobler and Edward Osborne Wilson discussed the predictive power of kin selection theory, a theory about the evolution of social behaviors. As part of Hölldobler's and Wilson's 1990 book titled The Ants, Hölldobler and Wilson compared predictions about the reproductive practices of ants to data about the reproductive practices of ants. They showed that the data generally supported the expected behaviors proposed by kin selection theory.

Format: Articles

Subject: Publications, Theories

The Effects of Bisphenol A on Embryonic Development

Bisphenol A (BPA) is an organic compound that was first synthesized by Aleksandr Dianin, a Russian chemist from St. Petersburg, in 1891. The chemical nomenclature of BPA is 2,2-bis (4-hydroxyphenyl) propane. The significance of this synthesized compound did not receive much attention until 1936, when two biochemists interested in endocrinology, Edward Dodds and William Lawson, discovered its ability to act as an estrogen agonist in ovariectomized, estrogen-deficient rats.

Format: Articles

Subject: Disorders, Reproduction

The Discovery of p53 Protein

The p53 protein acts as a pivotal suppressor of inappropriate cell proliferation. By initiating suppressive effects through induction of apoptosis, cell senescence, or transient cell-cycle arrest, p53 plays an important role in cancer suppression, developmental regulation, and aging. Its discovery in 1979 was a product of research into viral etiology and the immunology of cancer. The p53 protein was first identified in a study of the role of viruses in cancer through its ability to form a complex with viral tumor antigens.

Format: Articles

Subject: Experiments

Leo Loeb (1869-1959)

Leo Loeb developed an experimental approach to studying cancer and pioneered techniques for tissue culture and in vitro tissue transplantation which impacted early-to-mid twentieth century experimental embryology. Loeb received his medical degree from the University of Zurich in 1897. As part of his doctorate, he completed a thesis on the outcomes of tissue transplantation in guinea pigs. Loeb's thesis inspired a life-long interest in tissue transplantation.

Format: Articles

Subject: People

Temperature-Dependent Sex Determination in Reptiles

The sex of a reptile embryo partly results from the production of sex hormones during development, and one process to produce those hormones depends on the temperature of the embryo's environment. The production of sex hormones can result solely from genetics or from genetics in combination with the influence of environmental factors. In genotypic sex determination, also called genetic or chromosomal sex determination, an organism's genes determine which hormones are produced.

Format: Articles

Subject: Experiments

Wilhelm Johannsen's Genotype-Phenotype Distinction

Wilhelm Johannsen in Denmark first proposed the distinction between genotype and phenotype in the study of heredity in 1909. This distinction is between the hereditary dispositions of organisms (their genotypes) and the ways in which those dispositions manifest themselves in the physical characteristics of those organisms (their phenotypes). This distinction was an outgrowth of Johannsen's experiments concerning heritable variation in plants, and it influenced his pure line theory of heredity.

Format: Articles

Subject: Theories

General Embryological Information Service, published annually by the Hubrecht Laboratory, 1949-1981

The General Embryological Information Service (GEIS) was an annual report published by the Hubrecht Laboratory in Utrecht, The Netherlands from 1949 to 1981 that disseminated contemporary research information to developmental biologists. The purpose of the annual report was to catalog the names, addresses, and associated research of every developmental biologist in the world. Pieter Nieuwkoop edited each issue from 1949 until 1964, when Job Faber began assisting Nieuwkoop. Bert Z. Salome joined the editing team in 1968 before Nieuwkoop ceased editing duties in 1971.

Format: Articles

Subject: Organizations

Wilhelm Ludvig Johannsen (1857-1927)

Wilhelm Ludvig Johannsen studied plants and helped found the field of genetics, contributing methods and concepts to the study of heredity around the turn of the twentieth century in Denmark. His experiments on heredity and variation in plants influenced the methods and techniques of geneticists, and his distinction between the genotype of an organism-its hereditary disposition-and its phenotype-its observable characteristics-remains at the core of contemporary biology. Johannsen criticized biological explanations that relied on concepts such as vitalism and teleology.

Format: Articles

Subject: People

Golden Rice

Golden Rice was engineered from normal rice by Ingo Potrykus and Peter Beyer in the 1990s to help improve human health. Golden Rice has an engineered multi-gene biochemical pathway in its genome. This pathway produces beta-carotene, a molecule that becomes vitamin A when metabolized by humans. Ingo Potrykus worked at the Swiss Federal Institute of Technology in Zurich, Switzerland, and Peter Beyer worked at University of Freiburg, in Freiburg, Germany. The US Rockefeller Foundation supported their collaboration.

Format: Articles

Subject: Organisms, Legal

Eugenical Sterilization in the United States (1922), by Harry H. Laughlin

Eugenical Sterilization in the United States is a 1922 book in which author Harry H. Laughlin argues for the necessity of compulsory sterilization in the United States based on the principles of eugenics. The eugenics movement of the early twentieth century in the US focused on altering the genetic makeup of the US population by regulating immigration and sterilization, and by discouraging interracial procreation, then called miscegenation.

Format: Articles

Subject: Outreach, Legal, Ethics, Publications

Green Fluorescent Protein

Green fluorescent protein (GFP) is a protein in the jellyfish Aequorea Victoria that exhibits green fluorescence when exposed to light. The protein has 238 amino acids, three of them (Numbers 65 to 67) form a structure that emits visible green fluorescent light. In the jellyfish, GFP interacts with another protein, called aequorin, which emits blue light when added with calcium. Biologists use GFP to study cells in embryos and fetuses during developmental processes.

Format: Articles

Subject: Technologies

Lynn Petra Alexander Sagan Margulis (1938-2011)

Lynn Petra Alexander Sagan Margulis was an American biologist, whose work in the mid-twentieth century focused on cells living together in a mutually advantageous relationship, studied cells and mitochondria in the US during the second half of the twentieth century. She developed a theory for the origin of eukaryotic cells, that proposed two kinds of structures found in eukaryotic cells mitochondria in animals, and plastids in plantsÑwere once free-living bacteria that lived harmoniously and in close proximity to larger cells, a scenario called symbiosis.

Format: Articles

Subject: People, Theories

Jeter v. Mayo (2005)

In Jeter v. Mayo, the Court of Appeals of Arizona in 2005 held that a cryopreserved, three-day-old pre-embryo is not a person for purposes of Arizona's wrongful death statutes, and that the Arizona Legislature was best suited to decide whether to expand the law to include cryopreserved pre-embryos. The Court of Appeals affirmed a decision by the Maricopa County Superior Court to dismiss a couple's wrongful death claim after the Mayo Clinic (Mayo) allegedly lost or destroyed several of their cryopreserved pre-embryos.

Format: Articles

Subject: Reproduction, Legal

Nancy Goodman Brinker (1946– )

Nancy Goodman Brinker founded the largest breast cancer organization in the US, Susan G. Komen for the Cure, during the twentieth century. In 1982, Brinker created the organization, Susan G. Komen for the Cure, in memory of her sister, who had died of breast cancer two years earlier. During the early twentieth century, breast cancer was socially stigmatized, very few people discussed the disease, and there were limited treatment options available for those diagnosed with the disease.

Format: Articles

Subject: People

"Limitations in Abortion Legislation: A Comparative Study" (2007), by Orli Lotan

Written by Orli Lotan on behalf of the Knesset (Israeli Parliament) Center for Research and Information, "Limitations in Abortion Legislation: A Comparative Study" (hereafter abbreviated "Legislation") examines abortion legislation in Israel, the US, Canada, and a number of European countries. The study also acknowledges the medical, moral, ethical, and religious implications of abortion and the impact of such legislation on society in each country.

Format: Articles

Subject: Publications, Legal, Reproduction

Corpus Callosum Defects Associated with Fetal Alcohol Syndrome

Prenatal exposure to alcohol (ethanol) can result in a continuum of developmental abnormalities that are highly variable depending on the severity, duration, frequency, and timing of exposure during gestation. Defects of the corpus callosum (CC) have proven to be a reliable indicator of prenatal alcohol exposure as it affects the brain. Structural abnormalities of the CC occur along a continuum, like most alcohol-induced anomalies, whereby more severe prenatal exposure results in a greater expression of the abnormal trait.

Format: Articles

Subject: Disorders, Reproduction

Sir Graham Collingwood Liggins (1926-2010)

Sir Graham Collingwood Liggins devoted much of his professional life to obstetric research. Liggins demonstrated that hormones created by the fetus helped initiate labor, rather than hormones originating solely from the mother. Liggins also discovered that cortisol given to pregnant mothers helped delay premature labor, and that it increased the likelihood that premature infants would breathe normally after birth. Prior to cortisol treatment, premature infants often died of respiratory distress syndrome characterized by the inability to inflate immature lungs.

Format: Articles

Subject: People, Reproduction

Parasitic Twins

Parasitic twins, a specific type of conjoined twins, occurs when one twin ceases development during gestation and becomes vestigial to the fully formed dominant twin, called the autositic twin. The underdeveloped twin is called parasitic because it is only partially formed, is not functional, or is wholly dependent on the autositic twin.

Format: Articles

Subject: Disorders, Reproduction