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Carl Richard Moore (1892-1955)

Carl Richard Moore was a professor and researcher at the University of Chicago in Chicago, Illinois who studied sex hormones in animals from 1916 until his death in 1955. Moore focused on the role of hormones on sex differentiation in offspring, the optimal conditions for sperm production, and the effects of vasectomy or testicular implants on male sex hormone production. Moore's experiments to create hermaphrodites in the laboratory contributed to the theory of a feedback loop between the pituitary and fetal gonadal hormones to control sex differentiation.

Format: Articles

Subject: People

“Family Limitations” (1914), by Margaret Higgins Sanger

In 1914, Margaret Sanger published “Family Limitations,” a pamphlet describing six different types of contraceptive methods. At the time Sanger published the pamphlet, the federal Comstock Act of 1873 had made distributing contraceptive and abortion information through the US postal service illegal. The Comstock Act classified contraceptive information as obscene and limited the amount of information available to individuals about preventing pregnancies.

Format: Articles

Subject: Publications

Barbara Seaman (1935–2008)

Barbara Seaman was a writer, investigator, and advocate for female healthcare rights during the twentieth century in the United States. Seaman’s work addressed the gendered prejudice she observed in the US healthcare system and argued that women of the 1960s lacked the proper tools to make informed decisions about pregnancy care, breastfeeding, childbirth, and contraception. Seaman wrote the book The Doctor’s Case Against the Pill in 1969 to expose the dangers in prescribing and consuming high doses of estrogen in the form of birth control.

Format: Articles

Subject: People

Alec John Jeffreys (1950–)

Alec John Jeffreys created a process called DNA fingerprinting in the UK during the twentieth century. For DNA fingerprinting, technicians identify a person as the source of a biological sample by comparing the genetic information contained in the person's DNA to the DNA contained in the sample. Jeffreys developed the technique in the 1980s while at the University of Leicester in Leicester, UK. Jeffreys's technique had immediate applications. In forensic science, DNA fingerprinting enabled police to identify suspects of crimes based on their genetic identities.

Format: Articles

Subject: People

"Versuche zur Analyse der Induktionsmittel in der Embryonalentwicklung" (1932), by Hermann Bautzmann, Johannes Holtfreter, Otto Mangold, and Hans Spemann

In "Versuche zur Analyse der Induktionsmittel in der Embryonalentwicklung," published in Naturwissenschaften in 1932, Hermann Bautzmann, Johannes Holtfreter, Otto Mangold, and Hans Spemann jointly reported on experiments each had conducted testing the activity of organizers killed by boiling, freezing, alcohol, and drying. Each of the authors had been independently conducting similar experiments, when Holtfreter made a breakthrough allowing him to produce many more successful transplantations.

Format: Articles

Subject: Experiments

First American Birth Control Clinic (The Brownsville Clinic), 1916

On 16 October 1916, Margaret Sanger opened one of the first birth control clinics in the United States in Brooklyn, New York, which some have called the Brownsville Clinic. Located at 46 Amboy Street, the clinic was a place where Sanger and her staff verbally communicated with women seeking information about birth control. During the early 1900s, both birth control and abortion were illegal in the US, and publication or circulation of information on both topics was deemed obscene and illegal by the federal Comstock Act.

Format: Articles

Subject: Organizations

Robert Geoffrey Edwards (1925-2013)

Robert Geoffrey Edwards worked with Patrick Christopher Steptoe to develop in-vitro fertilization (IVF) techniques during the 1960s and 1970s in the United Kingdom. Louise Brown, the world' s first "test-tube baby," was born as a result of Edwards and Steptoe's IVF techniques in 1978, and since then more than four million children have been born using IVF techniques. Publicity and controversy accompanied Edwards and Steptoe's work as conservative religious institutions expressed concern over the morality of the IVF procedure.

Format: Articles

Subject: People, Reproduction

Cystic Fibrosis

Cystic fibrosis (CF) is a fatal, inherited disease found in humans and characterized by buildup of thick, sticky mucus, particularly in the respiratory and digestive tracts. The abnormally thick mucus prevents the pancreas from functioning normally; it often leads to digestive problems and chronic lung infections. Cystic fibrosis is most prevalent in Caucasian individuals, and approximately 1 in every 29 individuals in the US is a carrier for the mutated CF gene.

Format: Articles

Subject: Disorders

The Jane Collective (1969–1973)

The Jane Collective was an underground organization that provided illegal abortion services in Chicago, Illinois, from 1969 until abortions became legal in 1973. Formally called the Abortion Counseling Service of Women’s Liberation, the Jane Collective was a member organization and working group within Chicago Women’s Liberation Union that challenged the Illinois state legislature by providing abortions before they were legal in the US.

Format: Articles

Subject: Organizations

Sir Graham Collingwood Liggins (1926-2010)

Sir Graham Collingwood Liggins devoted much of his professional life to obstetric research. Liggins demonstrated that hormones created by the fetus helped initiate labor, rather than hormones originating solely from the mother. Liggins also discovered that cortisol given to pregnant mothers helped delay premature labor, and that it increased the likelihood that premature infants would breathe normally after birth. Prior to cortisol treatment, premature infants often died of respiratory distress syndrome characterized by the inability to inflate immature lungs.

Format: Articles

Subject: People, Reproduction

Planned Parenthood Center of Tucson (1950-1977)

Established in 1950, the Planned Parenthood Center of Tucson provided Arizona women with family planning resources until 1977, when it expanded to locations outside of Tucson and became Planned Parenthood of Southern Arizona. The Planned Parenthood Center of Tucson was formed after the Clinica Para Madres, the first birth control clinic in Arizona, merged with the national organization Planned Parenthood Federation of America.

Format: Articles

Subject: Organizations, Reproduction, Outreach

“Guideline for the Study and Evaluation of Gender Differences in the Clinical Evaluation of Drugs” (July 1993), by the United States Food and Drug Administration

The US Food and Drug Administration, or FDA, published the “Guideline for the Study and Evaluation of Gender Differences in the Clinical Evaluation of Drugs,” henceforth “Study of Gender Differences,” in July 1993. The document defined acceptable practices for investigators studying new drugs. Prior to 1993, investigators excluded most women from clinical trials because in 1977, the FDA recommended that anyone who could possibly become pregnant be excluded from early phase drug research to minimize risk to a potential fetus.

Format: Articles

Subject: Publications

"Adenocarcinoma of the Vagina: Association of Maternal Stilbestrol Therapy with Tumor Appearance in Young Women" (1971), by Arthur L. Herbst, et al.

Published in 1971, Adenocarcinoma of the Vagina: Association of Maternal Stilbestrol Therapy with Tumor Appearance in Young Women, by Arthurs L. Herbst and colleagues, was the first piece of literature connecting maternal use of the drug diethylstilbestrol (DES), also called stilbestrol, with the development of a rare and severe form of vaginal cancer in young women. Diethylstilbestrol was later classified as an endocrine disruptor, a substance that disrupts the hormonal function of the body in those exposed to it during development or later in life.

Format: Articles

Subject: Publications

Twice Born–Stories from the Special Delivery Unit (2015), by the Public Broadcasting Service and Trailblazer Studios

In 2015, the Public Broadcasting Service, or PBS, released a three-part documentary series, Twice Born–Stories from the Special Delivery Unit, hereafter Twice Born, that follows several pregnant women and their experiences with fetal surgery. Trailblazer Studios produced the film, which predominantly features two women, although it includes the stories of many women. The two main women are pregnant with fetuses diagnosed with physical deformities. One woman’s fetus is diagnosed with spina bifida, an incomplete closure of the fetus’s spinal column.

Format: Articles

Subject: Publications

Abortion

Abortion is the removal of the embryo or fetus from the womb, before birth can occur-either naturally or by induced labor. Prenatal development occurs in three stages: the zygote, or fertilized egg; the embryo, from post-conception to eight weeks; and the fetus, from eight weeks after conception until the baby is born. After abortion, the infant does not and cannot live. Spontaneous abortion is the loss of the infant naturally or accidentally, without the will of the mother. It is more commonly referred to as miscarriage.

Format: Articles

Subject: Processes, Ethics, Reproduction

Developmental Timeline of Alcohol-Induced Birth Defects

Maternal consumption of alcohol (ethanol) during pregnancy can result in a continuum of embryonic developmental abnormalities that vary depending on the severity, duration, and frequency of exposure of ethanol during gestation. Alcohol is a teratogen, an environmental agent that impacts the normal development of an embryo or fetus. In addition to dose-related concerns, factors such as maternal genetics and metabolism and the timing of alcohol exposure during prenatal development also impact alcohol-related birth defects.

Format: Articles

Subject: Disorders, Reproduction

Richard Doll (1912–2005)

Richard Doll was an epidemiologist and public figure in the twentieth and early twenty-first centuries. Working primarily at the University of Oxford, in Oxford, England, Doll established a definitive correlation between cigarette smoking and lung cancer. Furthermore, Doll’s work helped legitimize epidemiology as a scientific discipline. Doll’s research also helped establish modern guidelines for oncological studies, as well as for contemporary and future research on the effect of smoking on pregnancy and fetal development.

Format: Articles

Subject: People

Rock-Menkin Experiments

Dr. John Rock, a doctor of obstetrics and gynecology in Boston, and Miriam Menkin, Rock s hired lab technician, were the first researchers to fertilize a human egg outside of a human body in February of 1944. Their work was published on 4 August 1944 in an issue of Science in an article entitled "In Vitro Fertilization and Cleavage of Human Ovarian Eggs." This experiment marked the first time in history that a human embryo was produced outside of the human body, proving that in vitro fertilization was possible in humans.

Format: Articles

Subject: Experiments, Reproduction

Johns Hopkins Fertility Center

Johns Hopkins Medical Center, located in Baltimore, Maryland, opened in 1889; its associated medical school opened four years later. Today the hospital, a leading research center, contains many departments, including a fertility center that is renowned for taking on difficult cases that have been rejected by other fertility clinics. The fertility center was founded by physician Georgeanna Seegar Jones in 1939 as the Division of Reproductive Endocrinology in the gynecology department. The division expanded once formal training in reproductive endocrinology began in 1973.

Format: Articles

Subject: Organizations, Reproduction

Impact of Air Pollution on Reproductive Health” (1999), by Radim Srám

In 1999, researcher Radim Srám, sometimes spelled Radim Šrám, published his article “Impact of Air Pollution on Reproductive Health” in the journal Environmental Health Perspectives. In the article, Srám analyzes the effects of exposure to air pollution, which can include harmful chemicals, on fetal growth and development. Srám discusses how industrialized countries such as the US and China have led to an increase in the global amount of respirable air pollutants.

Format: Articles

Subject: Publications

Georgeanna Seegar Jones (1912-2005)

Georgeanna Seegar Jones was a reproductive endocrinologist who created one of America' s most successful infertility clinics in West Virginia and eventually, along with her husband Howard W. Jones MD, performed the first in vitro fertilization in America, leading to the birth of Elizabeth Jordan Carr. Jones was born in Baltimore, Maryland, on 6 July 1912. Her father, Dr. John King Beck Emory Seegar, was a practicing physician at the time working in the field of obstetrics.

Format: Articles

Subject: People, Reproduction

Julia Bell (1879-1979)

Julia Bell worked in twentieth-century Britain, discovered Fragile X Syndrome, and helped find heritable elements of other developmental and genetic disorders. Bell also wrote much of the five volume Treasury of Human Inheritance, a collection about genetics and genetic disorders. Bell researched until late in life, authoring an original research article on the effects of the rubella virus of fetal development (Congenital Rubella Syndrome) at the age of 80.

Format: Articles

Subject: People

Where Are My Children? (1916)

Where Are My Children? is an anti-abortion silent film released in the United States on 16 April 1916. The film was directed by Lois Weber and Phillips Smalley and produced by Universal Film Manufacturing Company/Lois Weber Productions in Universal City, California. In the film, Weber tells a story of an attorney who wants to have children and raise a family, but his wife chooses to abort her pregnancies, fearing that having children will ruin her social activities. In the early 1900s, information about contraception was not freely available or legal to obtain.

Format: Articles

Subject: Publications

Gunther von Hagens (1945- )

Gunther von Hagens invented a plastination technique and created Body Worlds, a traveling exhibit that has made anatomy part of the public domain. Von Hagens invented the plastination technique in 1977 while working at Heidelberg University in Heidelberg, Germany. Von Hagen's plastination technique preserves real bodies and tissues by the removal of the fluid and replacement with resin. Body Worlds features three-dimensional, plastinated human bodies.

Format: Articles

Subject: People, Outreach, Reproduction

Fetal Alcohol Syndrome (FAS)

The concept Fetal Alcohol Syndrome (FAS) refers to a set of birth defects that occur in children born to mothers who abused alcohol during pregnancy. The alcohol-induced defects include pre- and post-natal growth deficiencies, minor facial abnormalities, and damage to the developing central nervous system (CNS).

Format: Articles

Subject: Disorders