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Evaluation of the Newborn Infant--Second Report (1958), by Virginia Apgar et al.

Virginia Apgar and colleagues wrote “Evaluation of the Newborn Infant—Second Report” in 1958. This article explained that Apgar’s system for evaluating infants’ condition after birth accurately predicted the health of infants. Apgar had developed the scoring system in 1953 to provide a simple method for determining if an infant needed medical attention after birth.

Format: Articles

Subject: Reproduction, Publications

Methylmercury and Human Embryonic Development

Methylmercury (MeHg) is an organic form of mercury that can damage the developing brains of human fetuses. Women who consume methylmercury during pregnancy can bear children who have neurological issues because methylmercury has toxic effects on the nervous system during embryonic development. During the third week of gestation, the human nervous system begins to form in the embryo. During this gestational period, the embryo's nervous system is particularly susceptible to the influence of neurotoxins like methylmercury that can result in abnormalities.

Format: Articles

Subject: Reproduction, Disorders

Isotretinoin (Accutane) as a Teratogen

Isotretinoin is a molecule and a byproduct (metabolite) of vitamin A, and in greater than normal amounts in pregnant women, it can cause fetal abnormalities including cleft lips, ear and eye defects, and mental retardation. Isotretinoin is commonly called by its trade name Accutane, and it's a chemical compound derived from vitamin A, or retinoic acid. Doctors prescribe isotretinoin to treat severe acne. For pregnant women, too much vitamin A or isotretinoin can also cause greater than normal rates of stillbirths and fetal disintegrations after the ninth week of gestation.

Format: Articles

Subject: Reproduction, Disorders

Diethylstilbestrol (DES) in the US

Diethylstilbestrol (DES) is an artificially created hormone first synthesized in the late 1930s. Doctors widely prescribed DES first to pregnant women to prevent miscarriages, and later as an emergency contraceptive pill and to treat breast cancer. However, in 1971, physicians showed a link between DES and vaginal cancer during puberty in the children of women who had taken DES while pregnant. Consequently, the US Food and Drug Administration (FDA) banned its use during pregnancy.

Format: Articles

Subject: Reproduction, Technologies

Nuclear Magnetic Resonance Imaging to Visualize Fetal Abnormalities

Nuclear magnetic resonance imaging (MRI) is a technique to create a three-dimensional image of a fetus. Doctors often use MRIs to image a fetuses after an ultrasound has detected an, or has been inconclusive about an, abnormality. In 1983 researchers in Scotland first used MRI to visualize a fetus. MRIs showed a greater level of fetal detail than ultrasound images, and researchers recognized the relevance of this technique as a means to gather information about fetal development and growth.

Format: Articles

Subject: Technologies, Technologies, Reproduction

Howard Wilber Jones Jr.

Howard Wilber Jones Jr. and his wife, Georgeanna Seegar Jones, developed a method of in vitro fertilization and helped create the first baby in the US using that method. Though the first in vitro baby was born in England in 1978, Jones and his wife's contribution allowed for the birth of Elizabeth Carr on 28 December 1981. Jones, a gynecologist and an obstetrician, researched human reproduction for most of his life.

Format: Articles

Subject: People, Reproduction

Horatio Robinson Storer (1830–1922)

Horatio Robinson Storer was a surgeon and anti-abortion activist in the 1800s who worked in the field of women’s reproductive health and led the Physicians’ Crusade Against Abortion in the US. Historians credit Storer as being one of the first physicians to distinguish gynecology, the study of diseases affecting women and their reproductive health, as a separate subject from obstetrics, the study of pregnancy and childbirth.

Format: Articles

Subject: People, Reproduction, Religion

Whitner v. South Carolina (1997)

In the case Whitner v. South Carolina in 1997, the South Carolina State Supreme Court defined the concept of a child to include viable fetuses. This allowed grounds for prosecution of a pregnant womanÕs prenatal activity if those activities endangered or could potentially endanger the fetus within her. The case brought the issue of fetal rights versus pregnant womenÕs rights to light.

Format: Articles

Subject: Legal, Reproduction

Cocaine as a Teratogen

Cocaine use by pregnant women has a variety of effects on the embryo and fetus, ranging from various gastro-intestinal and cardiac defects to tissue death from insufficient blood supply. Thus, cocaine has been termed a teratogen, or an agent that causes defects in fetuses during prenatal development. Cocaine is one of the most commonly used drugs in the US and it has a history of both medical and illegal recreational use. It is a drug capable of a wide array of effects on physical and mental health.

Format: Articles

Subject: Reproduction, Disorders

Doolan v. IVF America [Brief] (2000)

The implication of the court's decision was that Thomas Doolan's identity or personhood existed at the embryo stage in vitro, thus the fact that he was born with cystic fibrosis was not attributable to the decision of the in vitro fertilization providers to implant one embryo instead of another. The other unused embryo may not have carried the cystic fibrosis genes, but that other embryo was not Thomas Doolan. The decision in Doolan has not been publicly tested in other jurisdictions.

Format: Articles

Subject: Legal, Reproduction

Paretta v. Medical Offices for Human Reproduction [Brief] (2003)

The court decided a child of in vitro fertilization born with cystic fibrosis does not have the right to sue for wrongful life even in the presence of demonstrable acts of medical negligence because to allow such a case would grant the IVF child rights not possessed by naturally born children. The decision in Paretta has not been publicly tested in other jurisdictions.

Format: Articles

Subject: Legal, Reproduction

Nettie Maria Stevens (1861-1912)

Multiple theories about what determines sex were tested at the turn of the twentieth century. By experimenting on germ cells, cytologist Nettie Maria Stevens collected evidence to support the connection between heredity and the sex of offspring. Stevens was able to interpret her data to conclude that chromosomes have a role in sex determination during development. For her time, she was an emerging breed: a woman of science making the leap from the world of data collection to that of male-dominated interpretive work.

Format: Articles

Subject: People, Reproduction

Sir Graham Collingwood Liggins (1926-2010)

Sir Graham Collingwood Liggins devoted much of his professional life to obstetric research. Liggins demonstrated that hormones created by the fetus helped initiate labor, rather than hormones originating solely from the mother. Liggins also discovered that cortisol given to pregnant mothers helped delay premature labor, and that it increased the likelihood that premature infants would breathe normally after birth. Prior to cortisol treatment, premature infants often died of respiratory distress syndrome characterized by the inability to inflate immature lungs.

Format: Articles

Subject: People, Reproduction

Fetus in Fetu

Fetus in fetu is a rare variety of parasitic twins , where the developmentally abnormal parasitic twin is completely encapsulated within the torso of the otherwise normally developed host twin. In the late eighteenth century, German anatomist Johann Friedrich Meckel was the first to described fetus in fetu, which translates to “fetus within fetus.” Fetus in fetu is thought to result from the unequal division of the totipotent inner cell mass , the mass of cells that is the ancestral precursor to all cells in the body.

Subject: Theories, Disorders, Reproduction

Robert Geoffrey Edwards (1925-2013)

Robert Geoffrey Edwards worked with Patrick Christopher Steptoe to develop in-vitro fertilization (IVF) techniques during the 1960s and 1970s in the United Kingdom. Louise Brown, the world' s first "test-tube baby," was born as a result of Edwards and Steptoe's IVF techniques in 1978, and since then more than four million children have been born using IVF techniques. Publicity and controversy accompanied Edwards and Steptoe's work as conservative religious institutions expressed concern over the morality of the IVF procedure.

Format: Articles

Subject: People, Reproduction

Planned Parenthood Center of Tucson (1950-1977)

Established in 1950, the Planned Parenthood Center of Tucson provided Arizona women with family planning resources until 1977, when it expanded to locations outside of Tucson and became Planned Parenthood of Southern Arizona. The Planned Parenthood Center of Tucson was formed after the Clinica Para Madres, the first birth control clinic in Arizona, merged with the national organization Planned Parenthood Federation of America.

Format: Articles

Subject: Organizations, Reproduction, Outreach

Abortion

Abortion is the removal of the embryo or fetus from the womb, before birth can occur-either naturally or by induced labor. Prenatal development occurs in three stages: the zygote, or fertilized egg; the embryo, from post-conception to eight weeks; and the fetus, from eight weeks after conception until the baby is born. After abortion, the infant does not and cannot live. Spontaneous abortion is the loss of the infant naturally or accidentally, without the will of the mother. It is more commonly referred to as miscarriage.

Format: Articles

Subject: Processes, Ethics, Reproduction

Developmental Timeline of Alcohol-Induced Birth Defects

Maternal consumption of alcohol (ethanol) during pregnancy can result in a continuum of embryonic developmental abnormalities that vary depending on the severity, duration, and frequency of exposure of ethanol during gestation. Alcohol is a teratogen, an environmental agent that impacts the normal development of an embryo or fetus. In addition to dose-related concerns, factors such as maternal genetics and metabolism and the timing of alcohol exposure during prenatal development also impact alcohol-related birth defects.

Format: Articles

Subject: Disorders, Reproduction

Rock-Menkin Experiments

Dr. John Rock, a doctor of obstetrics and gynecology in Boston, and Miriam Menkin, Rock s hired lab technician, were the first researchers to fertilize a human egg outside of a human body in February of 1944. Their work was published on 4 August 1944 in an issue of Science in an article entitled "In Vitro Fertilization and Cleavage of Human Ovarian Eggs." This experiment marked the first time in history that a human embryo was produced outside of the human body, proving that in vitro fertilization was possible in humans.

Format: Articles

Subject: Experiments, Reproduction

Johns Hopkins Fertility Center

Johns Hopkins Medical Center, located in Baltimore, Maryland, opened in 1889; its associated medical school opened four years later. Today the hospital, a leading research center, contains many departments, including a fertility center that is renowned for taking on difficult cases that have been rejected by other fertility clinics. The fertility center was founded by physician Georgeanna Seegar Jones in 1939 as the Division of Reproductive Endocrinology in the gynecology department. The division expanded once formal training in reproductive endocrinology began in 1973.

Format: Articles

Subject: Organizations, Reproduction

Georgeanna Seegar Jones (1912-2005)

Georgeanna Seegar Jones was a reproductive endocrinologist who created one of America' s most successful infertility clinics in West Virginia and eventually, along with her husband Howard W. Jones MD, performed the first in vitro fertilization in America, leading to the birth of Elizabeth Jordan Carr. Jones was born in Baltimore, Maryland, on 6 July 1912. Her father, Dr. John King Beck Emory Seegar, was a practicing physician at the time working in the field of obstetrics.

Format: Articles

Subject: People, Reproduction

Gunther von Hagens (1945- )

Gunther von Hagens invented a plastination technique and created Body Worlds, a traveling exhibit that has made anatomy part of the public domain. Von Hagens invented the plastination technique in 1977 while working at Heidelberg University in Heidelberg, Germany. Von Hagen's plastination technique preserves real bodies and tissues by the removal of the fluid and replacement with resin. Body Worlds features three-dimensional, plastinated human bodies.

Format: Articles

Subject: People, Outreach, Reproduction

Human Betterment Foundation (1928-1942)

In 1928 Ezra Seymour Gosney founded the non-profit Human Betterment Foundation (HBF) in Pasadena, California to support the research and publication of the personal and social effects of eugenic sterilizations carried out in California. Led by director Gosney and secretary Paul Popenoe, the HBF collected data on thousands of individuals in California who had been involuntarily sterilized under a California state law enacted in 1909. The Foundation's assets were liquidated following Gosney's death in 1942.

Format: Articles

Subject: Organizations, Reproduction

Robert Geoffrey Edwards's Study of Fertilization of Human Oocytes Matured in vitro, 1965 to 1969

Robert Geoffrey Edwards, a British developmental biologist at University of Cambridge, began exploring human in vitro fertilization (IVF) as a way to treat infertility in 1960. After successfully overcoming the problem of making mammalian oocytes mature in vitro in 1965, Edwards began to experiment with fertilizing matured eggs in vitro. Collaborating with other researchers, Edwards eventually fertilized a human egg in vitro in 1969. This was a huge step towards establishing human IVF as a viable fertility treatment.

Format: Articles

Subject: Experiments, Reproduction

Test-Tube Baby

A test-tube baby is the product of a successful human reproduction that results from methods beyond sexual intercourse between a man and a woman and instead utilizes medical intervention that manipulates both the egg and sperm cells for successful fertilization. The term was originally used to refer to the babies born from the earliest applications of artificial insemination and has now been expanded to refer to children born through the use of in vitro fertilization, the practice of fertilizing an embryo outside of a woman's body.

Format: Articles

Subject: Processes, Ethics, Reproduction