Between 1958 and 1962, physicians Olive W. Smith, George V. Smith, and Robert W. Kistner performed experiments that demonstrated the effects of the drugs MER-25 and clomiphene citrate on the female human

In the early twentieth century US, Jean Paul Pratt and Edgar Allen showed that if doctors injected estrogen into women with abnormal menstrual cycles, the cycles would become more normal. During clinical tests, researchers injected