Mesoderm is one of the three germ layers, groups of cells that interact early during the embryonic life of animals and from which organs and tissues form.
Among other functions, the Notch signaling prevents the differentiation of muscle progenitor cells into mature muscle in animals. The Notch signaling pathway is a pathway in animals by which two adjacent cells within an organism use a protein named Notch to mechanically interact with each other.
A germ layer is a group of cells in an embryo that interact with each other as the embryo develops and contribute to the formation of all organs and tissues. All animals, except perhaps sponges, form two or three germ layers.
In 1969, Roy J. Britten and Eric H. Davidson published “Gene Regulation for Higher Cells: A Theory,” in Science.