Roy John Britten studied DNA sequences in the US in the second half of the twentieth century, and he helped discover repetitive elements in DNA sequences. Additionally, Britten helped propose models and concepts of gene regulatory networks. Britten studied the
California Institute of Technology
Boris Ephrussi studied fruit flies, yeast, and mouse genetics and development while working in France and the US during the twentieth century. In yeast, Ephrussi studied how mutations in the cytoplasm persisted across generations. In mice he studied the genetics of hybrids and the development of cancer.
In 1969, Roy J. Britten and Eric H. Davidson published “Gene Regulation for Higher Cells: A Theory,” in Science.
In 2002 Eric Davidson and his research team published “A Genomic Regulatory Network for Development” in Science. The authors present the first experimental verification and systemic description of a gene regulatory network.