Abnormalities, Human

Studies of Thalidomide's Effects on Rodent Embryos from 1962-2008

Studies of Thalidomide's Effects on Rodent Embryos from 1962-2008

Thalidomide is a sedative drug introduced to European markets on 1 October 1957 after extensive testing on rodent embryos to ensure its safety. Early laboratory tests in rodent populations showed that pregnant rodents could safely use it, so doctors prescribed Thalidomide to treat morning sickness in pregnant women.

Teratogens

Teratogens

Teratogens are substances that may produce physical or functional defects in the human embryo or fetus after the pregnant woman is exposed to the substance. Alcohol and cocaine are examples of such substances.

"Congenital Club Foot in the Human Fetus" (1980), by Ernesto Ippolito and Ignacio Ponseti

Congenital Club Foot in the Human Fetus by Ernesto Ippolito and Ignacio Ponseti (1980)

In 1980, Ernesto Ippolito and Ignacio Ponseti published their results on a histological study they performed on congenital club foot in human fetuses. The researchers examined the feet of four aborted fetuses and compared the skeletal tissues from healthy feet to those affected by congenital club foot. Infants born with club foot are born with one or both feet rigidly twisted inwards and

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