The Food and Drug Administration’s Content and Format for Labeling for Human Prescription Drugs Rule, or the 1979 Labeling Rule, first assessed the risk of prescription drugs in pregnant women and fetuses. Prior to 1979, drug labels were only required to state true information, but there were no requirements for content or format.
In 2010, a team of US researchers concluded that the more peanuts a pregnant woman ate during her pregnancy, the more likely her newborn was to be sensitive to peanuts.
In the 1950s and 1960s, researchers Leon Chesley, John Annitto, and Robert Cosgrove investigated the possible familial factor for the conditions of preeclampsia and eclampsia in pregnant women. Preeclampsia and eclampsia, which are related to high blood pressure, have unknown causes and affect at least five percent of all pregnancies.
Virginia Apgar worked as an obstetrical anesthesiologist, administering drugs that reduce women's pain during childbirth, in the mid-twentieth century US. In 1953, Apgar created a scoring system using five easily assessable measurements, including heart rate and breathing rate, to evaluate whether or not infants would benefit from medical attention immediately after birth. Apgar's system showed that infants who were previously set aside as too sick to survive,
Leon Chesley studied hypertension, or high blood pressure, in pregnant women during the mid-twentieth century. Chesley studied preeclampsia and eclampsia, two hypertensive disorders found in approximately five percent of all US pregnancies. In New Jersey and New York, Chesley devoted over forty years to researching preeclampsia and eclampsia, and conducted several long-term studies using the same group of women beginning from their pregnancies. Chesley's