Estrogen plays a key role in the regulation of gene transcription. This is accomplished by its ability to act as a ligand and to bind to specific
In the early twentieth century US, Jean Paul Pratt and Edgar Allen showed that if doctors injected estrogen into women with abnormal menstrual cycles, the cycles would become more normal. During clinical tests, researchers injected
Eugen Steinach researched sex hormones and their effects on mammals in the late nineteenth and early twentieth centuries in Europe.