Experiments

"A molecular wound response program associated with regeneration initiation in planarians" (2012), by Danielle Wenemoser et al.

By Joe Brinkman

In 2012, a team of scientists across the US conducted an experiment to find the mechanism that allowed a group of flatworms, planarians, to regenerate any body part. The group included Danielle Wenemoser, Sylvain Lapan, Alex Wilkinson, George Bell, and Peter Reddien. They aimed to identify genes that are expressed by planarians in response to wounds that initiated a regenerative mechanism. The researchers determined several genes as important for tissue regeneration.

Created 2017-05-09

Last modified 1 month 2 weeks ago

Format: Articles

Calvin Bridges’ Experiments on Nondisjunction as Evidence for the Chromosome Theory of Heredity (1913-1916)

By Kevin Gleason

From 1913 to 1916, Calvin Bridges performed experiments that indicated genes are found on chromosomes. His experiments were a part of his doctoral thesis advised by Thomas Hunt Morgan in New York, New York. In his experiments, Bridges studied Drosophila, the common fruit fly, and by doing so showed that a process called nondisjunction caused chromosomes, under some circumstances, to fail to separate when forming sperm and egg cells. Nondisjunction, as described by Bridges, caused sperm or egg cells to contain abnormal amounts of chromosomes.

Created 2017-05-18

Last modified 1 month 1 week ago

Format: Articles

“Sex Limited Inheritance in Drosophila” (1910), by Thomas Hunt Morgan

By Kevin Gleason

In 1910, Thomas Hunt Morgan performed an experiment at Columbia University, in New York City, New York, that helped identify the role chromosomes play in heredity. That year, Morgan was breeding Drosophila, or fruit flies. After observing thousands of fruit fly offspring with red eyes, he obtained one that had white eyes. Morgan began breeding the white-eyed mutant fly and found that in one generation of flies, the trait was only present in males.

Created 2017-05-22

Last modified 1 month 6 days ago

Format: Articles

"The linear arrangement of six sex-linked factors in drosophila, as shown by their mode of association” (1913), by Alfred Henry Sturtevant

By Kevin Gleason

In 1913, Alfred Henry Sturtevant published the results of experiments in which he showed how genes are arranged along a chromosome. Sturtevant performed those experiments as an undergraduate at Columbia University, in New York, New York, under the guidance of Nobel laureate Thomas Hunt Morgan. Sturtevant studied heredity using Drosophila, the common fruit fly. In his experiments, Sturtevant determined the relative positions of six genetic factors on a fly’s chromosome by creating a process called gene mapping.

Created 2017-05-22

Last modified 1 month 5 days ago

Format: Articles

Sonja Vernes, et al.'s Experiments On the Gene Networks Affected by the Foxp2 Protein (2011)

By Kat Fowler

In 2011, Sonja Vernes and Simon Fisher performed a series of experiments to determine which developmental processes are controlled by the mouse protein Foxp2. Previous research showed that altering the Foxp2 protein changed how neurons grew, so Vernes and Fisher hypothesized that Foxp2 would affect gene networks that involved in the development of neurons, or nerve cells. Their results confirmed that Foxp2 affected the development of gene networks involved in the growth of neurons, as well as networks that are involved in cell specialization and cell communication.

Created 2017-05-30

Last modified 4 days 4 hours ago

Format: Articles

"Control of Corneal Differentiation by Extracellular Materials" (1974), by Stephen Meier and Elizabeth D. Hay

By Kevin Gleason

In 1974, Elizabeth Dexter Hay and Stephen Meier in the US conducted an experiment that demonstrated that the extracellular matrix, the mesh-like network of proteins and carbohydrates found outside of cells in the body, interacted with cells and affected their behaviors. In the experiment, Hay and Meier removed the outermost layer of cells that line the front of the eye, called corneal epithelium, from developing chick embryos.

Created 2017-06-19

Last modified 1 week 1 day ago

Format: Articles

Hox Genes and the Evolution of Vertebrate Axial Morphology Experiment (1995)

By Joe Brinkman

In 1995, researchers Ann Burke, Craig Nelson, Bruce Morgan, and Cliff Tabin in the US studied the genes that regulate the construction of vertebra in developing chick and mouse embryos, they showed similar patterns of gene regulation across both species, and they concluded that those patterns were inherited from an ancestor common to all vertebrate animals. The group analyzed the head-to-tail (anterior-posterior) axial development of vertebrates, as the anterior-posterior axis showed variation between species over the course of evolutionary time.

Created 2017-06-23

Last modified 4 days 9 hours ago

Format: Articles

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