Title By Description Created Last modifiedsort ascending
“Sex Limited Inheritance in Drosophila” (1910), by Thomas Hunt Morgan Kevin Gleason In 1910, Thomas Hunt Morgan performed an experiment at Columbia University, in New York City, New York, that helped identify the role chromosomes play in heredity. That year, Morgan was breeding Drosophila, or fruit flies. After observing thousands of fruit fly offspring with red eyes, he obtained one that had white eyes. Morgan began breeding the white-eyed mutant fly and found that in one generation of flies, the trait was only present in males. 2017-05-22 23 May 2017
The linear arrangement of six sex-linked factors in drosophila, as shown by their mode of association” (1913), by Alfred Henry Sturtevant Kevin Gleason In 1913, Alfred Henry Sturtevant published the results of experiments in which he showed how genes are arranged along a chromosome. Sturtevant performed those experiments as an undergraduate at Columbia University, in New York, New York, under the guidance of Nobel laureate Thomas Hunt Morgan. Sturtevant studied heredity using Drosophila, the common fruit fly. In his experiments, Sturtevant determined the relative positions of six genetic factors on a fly’s chromosome by creating a process called gene mapping. 2017-05-22 23 May 2017
Calvin Bridges’ Experiments on Nondisjunction as Evidence for the Chromosome Theory of Heredity (1913-1916) Kevin Gleason From 1913 to 1916, Calvin Bridges performed experiments that indicated genes are found on chromosomes. His experiments were a part of his doctoral thesis advised by Thomas Hunt Morgan in New York, New York. In his experiments, Bridges studied Drosophila, the common fruit fly, and by doing so showed that a process called nondisjunction caused chromosomes, under some circumstances, to fail to separate when forming sperm and egg cells. Nondisjunction, as described by Bridges, caused sperm or egg cells to contain abnormal amounts of chromosomes. 2017-05-18 18 May 2017
"A molecular wound response program associated with regeneration initiation in planarians" (2012), by Danielle Wenemoser et al. Joe Brinkman In 2012, a team of scientists across the US conducted an experiment to find the mechanism that allowed a group of flatworms, planarians, to regenerate any body part. The group included Danielle Wenemoser, Sylvain Lapan, Alex Wilkinson, George Bell, and Peter Reddien. They aimed to identify genes that are expressed by planarians in response to wounds that initiated a regenerative mechanism. The researchers determined several genes as important for tissue regeneration. 2017-05-09 9 May 2017
"Congenital Club Foot in the Human Fetus" (1980), by Ernesto Ippolito and Ignacio Ponseti Katherine Gandee In 1980, Ernesto Ippolito and Ignacio Ponseti published their results on a histological study they performed on congenital club foot in human fetuses. The researchers examined the feet of four aborted fetuses and compared the skeletal tissues from healthy feet to those affected by congenital club foot. Infants born with club foot are born with one or both feet rigidly twisted inwards and upwards, making typical movement painful and challenging. 2017-03-16 7 May 2017
Serial Cultivation of Human Diploid Cells in the Lab (1958–1961) by Leonard Hayflick and Paul S. Moorhead Christian H. Ross From 1958 to 1961, Leonard Hayflick and Paul Moorhead in the US developed a way in the laboratory to cultivate strains of human cells with complete sets of chromosomes. Previously, scientists could not sustain cell cultures with cells that had two complete sets of chromosomes like normal human cells (diploid). As a result, scientists struggled to study human cell biology because there was not a reliable source of cells that represented diploid human cells. In their experiments, Hayflick and Moorhead created lasting strains of human cells that retained both complete sets of chromosomes. 2017-04-27 7 May 2017
Treatment of Anemia during Pregnancy (1931), by Lucy Wills Lauren Lynch In 1931, physician Lucy Wills conducted a study of nutritional deficiencies that caused anemia in pregnant women in Bombay, India, later renamed Mumbai. Anemia is a lack of healthy red blood cells in the blood. Wills published the results of her study in the medical article 'Treatment of ‘Pernicious Anaemia of Pregnancy' and 'Tropical Anaemia'' in the British Medical Journal in 1931. Wills's research contributed to knowledge of anemia and the possible causes associated with the disease, such as the symptoms of fatigue and irritability. 2017-04-20 7 May 2017
“A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation” (1993), by Dean H. Hamer and Charles A. Thomas. Christina Nguyen In 1993, Dean H. Hamer and colleagues in the US published results from their research that indicated that men with speicifc genes were more likely to be homosexual than were men without those genes. The study hypothesized that some X chromosomes contain a gene, Xq28, that increases the likelihood of an individual to be homosexual. Prior to those results, researchers had argued that the cause of homosexuality was environmental and that homosexuality could be altered or reversed. Hamer’s research suggested a possible genetic cause of homosexuality. 2017-04-13 7 May 2017
"The Association between Depressive Symptoms and Social Support in Taiwanese Women During the Month" (2004), by Shu-Shya Heh et al. Cecilia Chou In 2004, Shu-Shya Heh, Lindsey Coombes, and Helen Bartlett studied the association between Chinese postpartum (post-childbirth) practices and postpartum depression in Taiwanese women. The researchers surveyed Taiwanese women about the social support they received after giving birth and then evaluated the depression rates in the same women. Heh and her colleagues focused on the month following childbirth, which according to traditional Chinese medicine, is an important period that warrants a set of specialized practices to aid the woman's recovery. 2017-04-11 7 May 2017
Christian Peeters and Bert Hölldobler's Experiments on Reproduction in Indian Jumping Ants (1991–1994) Kelle Dhein Between 1991 and 1994, Christian Peeters and Bert Hölldobler studied the reproductive behaviors of the Indian jumping ant (Harpegnathos saltator), a species native to southern India. They conducted experiments as part of a larger investigation into conflict and reproductive behavior among ants. Peeters and Hölldobler discovered that Indian jumping ant colonies contained both sexually reproductive workers and egg-laying queens. In most other species of ant, the queens are the only sexually reproductive individuals. 2017-03-23 7 May 2017
Infant Mortality: Results of a Field Study in Johnstown, PA., Based on Births in One Calendar Year (1915), by Emma Duke Katherine Madgett The book Infant Mortality: Results of a Field Study in Johnstown, PA., Based on Births in One Calendar Year (1915), written by Emma Duke, detailed one of the first infant mortality field studies conducted by the US Children's Bureau. In the study, Duke and her colleagues collected information about over one thousand infants in the city of Johnstown, Pennsylvania. They used that information, along with interviews conducted with the families of the infants, to identify factors that affected infant mortality rates in the community. 2017-03-23 7 May 2017
"The Developmental Capacity of Nuclei Taken from Intestinal Epithelium Cells of Feeding Tadpoles" (1962), by John B. Gurdon Giselle Lee In 1962 researcher John Bertrand Gurdon at the University of Oxford in Oxford, England, conducted a series of experiments on the developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. In the experiments, Gurdon conducted nuclear transplantation, or cloning, of differentiated cells, or cells that have already specialized to become one cell type or another, in tadpoles. Gurdon's experiment showed that differentiated adult cells could be induced to an undifferentiated state, where they could once again become multiple cell types. 2017-03-16 7 May 2017
"The Familial Factor in Toxemia of Pregnancy" (1968), by Leon C. Chesley, et al. Sarah Patel In the 1950s and 1960s, researchers Leon Chesley, John Annitto, and Robert Cosgrove investigated the possible familial factor for the conditions of preeclampsia and eclampsia in pregnant women. Preeclampsia and eclampsia, which are related to high blood pressure, have unknown causes and affect at least five percent of all pregnancies. 2017-03-16 7 May 2017
Ginger as a Treatment for Nausea and Vomiting in Pregnancy by Teraporn Vutyavanich, Theerajana Kraisarin, and Rung-Aroon Ruangsri (1998–2001) Cecilia Chou In 1998 and 1999, Teraporn Vutyavanich, Theerajana Kraisarin, and Rung-Aroon Ruangsri in Thailand showed that ginger alleviated nausea in pregnant women. Vutyavanich and his colleagues found that the group of pregnant women who took ginger capsules reported significantly fewer nausea symptoms and vomiting episodes than the group who only received the placebo. Vutyavanich and his team’s study at Chiang Mai University in Chiang Mai, Thailand, was one of the earliest to investigate and support the use of ginger as an effective treatment for relieving pregnancy-related nausea and vomiting. 2017-03-14 7 May 2017
Harald zur Hausen's Experiments on Human Papillomavirus Causing Cervical Cancer (1976–1987) Grace Kim From 1977 to 1987, Harald zur Hausen led a team of researchers across several institutions in Germany to investigate whether the human papillomavirus (HPV) caused cervical cancer. Zur Hausen's first experiment tested the hypothesis that HPV caused cervical cancer rather than herpes simplex virus type 2 (HSV-2), the then accepted cause. His second and third experiments detailed methods to identify two previously unidentified HPV strains, HPV 16 and HPV 18, in cervical cancer tumor samples. The experiments showed that HPV 16 and 18 DNA were present in cervical tumor samples. 2017-03-09 7 May 2017
Hermann Joseph Muller's Study of X-rays as a Mutagen, (1926-1927) Kevin M. Gleason Hermann Joseph Muller conducted three experiments in 1926 and 1927 that demonstrated that exposure to x-rays, a form of high-energy radiation, can cause genetic mutations, changes to an organism's genome, particularly in egg and sperm cells. In his experiments, Muller exposed fruit flies (Drosophila) to x-rays, mated the flies, and observed the number of mutations in the offspring. In 1927, Muller described the results of his experiments in "Artificial Transmutation of the Gene" and "The Problem of Genic Modification". 2017-03-07 7 May 2017
"Presence of Fetal DNA in Maternal Plasma and Serum" (1997), by Dennis Lo, et al. Cassidy Possehl In the late 1990s researchers Yuk Ming Dennis Lo and his colleagues isolated fetal DNA extracted from pregnant woman’s blood. The technique enabled for more efficient and less invasive diagnoses of genetic abnormalities in fetuses, such as having too many copies of chromosomes. 2017-03-07 7 May 2017
Edgar Allen and Edward A. Doisy's Extraction of Estrogen from Ovarian Follicles, (1923) Brendan Van Iten In the early 1920s, researchers Edgar Allen and Edward Adelbert Doisy conducted an experiment that demonstrated that ovarian follicles, which produce eggs in mammals, also contain and produce what they called the primary ovarian hormone, later renamed estrogen. In their experiment, Doisy and Allen extracted estrogen from the ovarian follicles of hogs and proved that they had isolated estrogen by using a measurement later renamed the Allen-Doisy test. 2017-03-02 7 May 2017
The Effectiveness of Phototherapy in Premature Infants (1968) Arianna Bradley In 1968, pediatric researchers Jerold Lucey, Mario Ferreiro, and Jean Hewitt conducted an experimental trial that determined that exposure to light effectively treated jaundice in premature infants. The three researchers published their results in 'Prevention of Hyperbilirubinemia of Prematurity by Phototherapy' that same year in Pediatrics. Jaundice is the yellowing of the skin and eyes due to the failure of the liver to break down excess bilirubin in the blood, a condition called hyperbilirubinemia. 2017-02-23 7 May 2017
Gene Transfer Strategy Used to Treat Tay - Sachs Disease (2005), by Sabata Martino’s Research Group Tiffany Nardi In the early 2000s, Sabata Martino and a team of researchers in Italy and Germany showed that they could reduce the symptoms of Tay-Sachs in afflicted mice by injecting them with a virus that infected their cells with a gene they lacked. Tay-Sachs disease is a fatal degenerative disorder that occurs in infants and causes rapid motor and mental impairment, leading to death at the ages of three to five. In gene therapy, researchers insert normal genes into cells that have missing or defective genes in order to correct genetic disorders. 2017-02-21 7 May 2017
The Effects of Gene Regulation on Aging in Caenorhabditis elegans (2003) Dasia Garcia In 2003, molecular biology and genetics researchers Coleen T. Murphy, Steven A. McCarroll, Cornelia I. Bargmann, Andrew Fraser, Ravi S. Kamath, Julie Ahringer, Hao Li, and Cynthia Kenyon conducted an experiment that investigated the cellular aging in, Caenorhabditis elegans (C. elegans) nematodes. The researchers investigated the interactions between the transcription factor DAF-16 and the genes that regulate the production of an insulin-like growth factor 1 (IGF-1-like) protein related to the development, reproduction, and aging in C. elegans. 2017-02-16 7 May 2017
Barbara McClintock's Transposon Experiments in Maize (1931–1951) Federica Turriziani Colonna Barbara McClintock conducted experiments on corn (Zea mays) in the United States in the mid-twentieth century to study the structure and function of the chromosomes in the cells. McClintock researched how genes combined in corn and proposed mechanisms for how those interactions are regulated. McClintock received the Nobel Prize in Physiology or Medicine in 1983, the first woman to win the prize without sharing it. McClintock won the award for her introduction of the concept of transposons, also called jumping genes. 2017-02-09 7 May 2017
The Meselson-Stahl Experiment (1957–1958), by Matthew Meselson and Franklin Stahl Victoria Hernandez In an experiment later named for them, Matthew Stanley Meselson and Franklin William Stahl in the US demonstrated during the 1950s the semi-conservative replication of DNA, such that each daughter DNA molecule contains one new daughter subunit and one subunit conserved from the parental DNA molecule. The researchers conducted the experiment at California Institute of Technology (Caltech) in Pasadena, California, from October 1957 to January 1958. 2017-04-18 18 April 2017
Jeffrey Weinzweig's Experiments on In Utero Cleft Palate Repair in Goats (1999-2002) Jillian R. Kersten Jeffrey Weinzweig and his team, in the US at the turn of the twenty-first century, performed a series of experiments on fetal goats to study the feasibility of repairing cleft palates on organisms still in the womb. Weinzweig , a plastic surgeon who specialized in cleft palate repair, and his team developed a method to cause cleft palates in fetal goats that are similar to clefts that occur in human fetuses. Using their goat congenital model, the team developed a method to repair a congenital cleft palate in utero, or in the womb. 2017-04-07 12 April 2017
Clinical Tests of Estrogen Injections on Women with Abnormal Menstrual Cycles During the Early 1920s by Jean Paul Pratt and Edgar Allen Brendan Van Iten In the early twentieth century US, Jean Paul Pratt and Edgar Allen conducted clinical experiments on women who had abnormal menstrual cycles. During the clinical tests, researchers injected the hormone estrogen into their patients to alleviate their menstrual ailments, which ranged from irregular cycles to natural menopause. The hormone estrogen plays a prominent role in the menstrual cycle by signaling the tissue lining the uterus (endometrium) to thicken in preparation for possible pregnancy. 2017-04-06 6 April 2017
Julia Barlow Platt's Embryological Observations on Salamanders' Cartilage (1893) Karina Ramirez In 1893, Julia Barlow Platt published her research on the origins of cartilage in the developing head of the common mudpuppy (Necturus maculosus) embryo. The mudpuppy is an aquatic salamander commonly used by embryologists because its large embryonic cells and nuclei are easy to see. Platt followed the paths of cells in developing mudpuppy embryos to see how embryonic cells migrated during the formation of the head. With her research, Platt challenged then current theories about germ layers, the types of cells in an early embryo that develop into adult cells. 2017-03-06 6 March 2017
"The Limited In Vitro Lifetime of Human Diploid Cell Strains" (1964), by Leonard Hayflick Zane Bartlett Leonard Hayflick in the US during the early 1960s showed that normal populations of embryonic cells divide a finite number of times. He published his results as 'The Limited In Vitro Lifetime of Human Diploid Cell Strains' in 1964. Hayflick performed the experiment with WI-38 fetal lung cells, named after the Wistar Institute, in Philadelphia, Pennsylvania, where Hayflick worked. Frank MacFarlane Burnet, later called the limit in capacity for cellular division the Hayflick Limit in 1974. 2017-02-11 12 February 2017
Beadle and Tatum's 1941 Experiments with Neurospora Revealed that Genes Produce Enzymes Amy Pribadi Object is a digital image that depicts four stages in Beadle and Tatum's Neurospora experiments. Each stage is depicted in a separate section, with different test tubes in each section.This illustration shows George Beadle and Edward Tatum's experiments with Neurospora crassa that indicated that single genes produce single enzymes. The pair conducted the experiments at Stanford University in Palo Alto, California. Enzymes are types of proteins that can catalyze reactions inside cells, reactions that produce a number of things, including nutrients that the cell needs. Neurospora crassa is a species of mold that grows on bread. 2016-10-12 12 October 2016
Beadle and Ephrussi Show that Something Besides Eye Tissue Determines Eye Color in Fruit Flies Amy Pribadi Object is a digital image of fruit flies, and it has three panes. The first pane shows two fruit fly larvae, with one having its optic disc removed and the other getting that disc inserted in its abdomen. The second pane shows an adult fruit fly, a donee, which has a normal colored eye in its abdomen. The third pane shows an adult fruit fly, a donee, which has an abnormally colored eye in its abdomen.In the 1930s, George Beadle and Boris Ephrussi discovered factors that affect eye colors in developing fruit flies. They did so while working at the California Institute of Technology in Pasadena, California. (1) They took optic discs (colored fuchsia in the image) from fruit fly larvae in the third instar stage of development. Had the flies not been manipulated, they would have developed into adults with vermilion eyes. 2016-10-11 12 October 2016
Beadle and Ephrussi’s Technique to Transplant Optic Discs between Fruit Fly Larvae Amy Pribadi Object is a digital image of fruit fly larvae. There are three panes. In the first, a micropipette sucks the optic disc from a fruit fly larva. In the second, the micropipette pushes the optic disc into the abdomen of another fruit fly larva. The third pane shows the adult fruit fly from the second pane with an eye that has developed in its abdomen.In 1935, George Beadle and Boris Ephrussi developed a technique to transplant optic discs between fruit fly larvae. They developed it while at the California Institute of Technology in Pasedena, California. Optic discs are tissues from which the adult eyes develop. Beadle and Ephrussi used their technique to study the development of the eye and eye pigment. (1) The experimenter dissects a donor larva, which is in the third instar stage of development, and removes the optic disc (colored red) with a micropipette. 2016-10-11 12 October 2016
Corticosteroids' Effect on Fetal Lung Maturation (1972), by Sir Graham Collingwood Liggins and Ross Howie Kathleen O'Connor, Erica O'Neil In a clinical trial from 1969 to 1972, Sir Graham Collingwood Liggins and Ross Howie showed that if doctors treat pregnant women with corticosteroids before those women deliver prematurely, then those women's infants have fewer cases of respiratory distress syndrome than do similarly premature infants of women not treated with corticosteroids. Prior to the study, premature infants born before 32 weeks of gestation often died of respiratory distress syndrome, or the inability to inflate immature lungs. 2012-12-19 4 October 2016
"On the Induction of Embryonic Primordia by Implantation of Organizers from Different Species" (1924), Hilde Mangold's Dissertation Megan Kearl, Kate MacCord Hilde Proscholdt Mangold was a doctoral student at the Zoological Institute at the University of Freiburg in Freiburg, Germany, from 1920-1923. Mangold conducted research for her dissertation 'On the Induction of Embryonic Primordia by Implantation of Organizers from Different Species' ('Ueber Induktion von Embryonanlagen durch Implantation artfremder Organisatoren'), under the guidance of Hans Spemann, a professor of zoology at the University of Freiburg. 2012-12-19 4 October 2016
"Maternal Thyroid Deficiency During Pregnancy and Subsequent Neuropsychological Development of the Child" (1999), by James E. Haddow et al. Jennifer R. Craer From 1987 to the late 1990s, James Haddow and his team of researchers at the Foundation for Blood Research in Scarborough, Maine, studied children born to women who had thyroid deficiencies while pregnant with those children. Haddow's team focused the study on newborns who had normal thyroid function at the time of neonatal screening. They tested the intelligence quotient, or IQ, of the children, ages eight to eleven years, and found that all of the children born to thyroid-hormone deficient mothers performed less well than the control group. 2014-07-11 4 October 2016
Elizabeth Blackburn, Carol Greider and Jack Szostak's Telomere and Telomerase Experiments (1982-1989) Zane Bartlett Experiments conducted by Elizabeth Blackburn, Carol Greider, and Jack Szostak from 1982 to 1989 provided theories of how the ends of chromosomes, called telomeres, and the enzyme that repairs telomeres, called telomerase, worked. The experiments took place at the Sidney Farber Cancer Institute and at Harvard Medical School in Boston, Massachusetts, and at the University of California in Berkeley, California. For their research on telomeres and telomerase, Blackburn, Greider, and Szostak received the Nobel Prize in Physiology or Medicine in 2009. 2015-03-24 4 October 2016
"Human Toxoplasmosis: Occurrence in Infants as an Encephalomyelitis Verification of Transmission to Animals" (1939), by Abner Wolf et al. Jesse Potestas In a series of experiments during mid 1930s, a team of researchers in New York helped establish that bacteria of the species Toxoplasma gondii can infect humans, and in infants can cause toxoplasmosis, a disease that inflames brains, lungs, and hearts, and that can organisms that have it. The team included Abner Wolf, David Cowen, and Beryl Paige. They published the results of their experiment in Human Toxoplasmosis: Occurrence in Infants as an Encephalomyelitis Verification of Transmission to Animals. 2015-06-11 22 June 2016
Induced Pluripotent Stem Cell Experiments by Kazutoshi Takahashi and Shinya Yamanaka in 2006 and 2007 Zane Bartlett In 2006, Kazutoshi Takahashi and Shinya Yamanaka reprogrammed mice fibroblast cells, which can produce only other fibroblast cells, to become pluripotent stem cells, which have the capacity to produce many different types of cells. Takahashi and Yamanaka also experimented with human cell cultures in 2007. Each worked at Kyoto University in Kyoto, Japan. They called the pluripotent stem cells that they produced induced pluripotent stem cells (iPSCs) because they had induced the adult cells, called differentiated cells, to become pluripotent stem cells through genetic manipulation. 2015-06-01 3 June 2015
The Genetic Control and Cytoplasmic Expression of 'Inducibility' in the synthesis of B-galactosidase" (1959), by Arthur B. Pardee, Francois Jacob, and Jacques Monod Abhinav Mishra Between 1957 and 1959, Arthur Pardee, Francois Jacob, and Jacques Monod conducted a set of experiments at the Pasteur Institute in Paris, France, that was later called the PaJaMa Experiments, a moniker derived from the researchers' last names. In these experiments, they described how genes of a species of single-celled bacteria, called Escherichia coli (E. coli), controlled the processes by which enzymes were produced in those bacteria. 2015-05-28 1 June 2015
Digit Regeneration Is Regulated by Msx1 and BMP4 in Fetal Mice (2003), by Manjong Han et al. Joe Brinkman In the early 2000s, Manjong Han, Xiaodang Yang, Jennifer Farrington, and Ken Muneoka investigated how genes and proteins in fetal mice (Mus musculus) influenced those fetal mice to regenerate severed toes at Tulane University in New Orleans, Louisiana. The group used hind limbs from mice to show how the gene Msx1 (Homeobox 7) functions in regenerating amputated digits. 2015-04-13 13 April 2015
Paul Kammerer's Experiments on Sea-squirts in the Early Twentieth Century Federica Turriziani Colonna In the early twentieth century, Paul Kammerer, a zoologist working at the Vivarium in Vienna, Austria, experimented on sea-squirts (Ciona intestinalis). Kammerer claimed that results from his experiments demonstrated that organisms could transmit characteristics that they had acquired in their lifetimes to their offspring. Kammerer conducted breeding experiments on sea-squirts and other organisms at a time when Charles Darwin's 1859 theory of evolution lacked evidence to explain how offspring inherited traits from their parents. 2015-04-13 13 April 2015
"Development, Plasticity and Evolution of Butterfly Eyespot Patterns" (1996), by Paul M. Brakefield et al. Yawen Zou Paul M. Brakefield and his research team in Leiden, the Netherlands, examined the development, plasticity, and evolution of butterfly eyespot patterns, and published their findings in Nature in 1996. Eyespots are eye-shaped color patterns that appear on the wings of some butterflies and birds as well as on the skin of some fish and reptiles. In butterflies, such as the peacock butterfly Aglais, the eyespots resemble the eyes of birds and help butterflies deter potential predators. 2013-09-10 9 April 2015
"Developmental Capacity of Nuclei Transplanted from Keratinized Skin Cells of Adult Frogs" (1975), by John Gurdon, Ronald Laskey, and O. Raymond Reeves Sean Cohmer In 1975 John Gurdon, Ronald Laskey, and O. Raymond Reeves published "Developmental Capacity of Nuclei Transplanted from Keratinized Skin Cells of Adult Frogs," in the Journal of Embryology and Experimental Morphology. Their article was the capstone of a series of experiments performed by Gurdon during his time at Oxford and Cambridge, using the frog species Xenopus laevis. Gurdon's first experiment in 1958 showed that the nuclei of Xenopus cells maintained their ability to direct normal development when transplanted. 2011-06-14 9 April 2015
"Programmed Cell Death-II. Endocrine Potentiation of the Breakdown of the Intersegmental Muscles of Silkmoths" (1964), by Richard A. Lockshin and Carroll M. Williams Lijing Jiang Richard A. Lockshin's 1963 PhD dissertation on cell death in insect metamorphosis was conducted under the supervision of Harvard insect physiologist Carroll M. Williams. Lockshin and Williams used this doctoral research as the basis for five articles, with the main title "Programmed Cell Death," that were published between 1964 and 1965 in the Journal of Insect Physiology. These articles examine the cytological processes, neuronal and endocrinal controls, and the influence of drugs on the mechanism of cell death observed in pupal muscle structures of the American silkmoth. 2011-04-27 9 April 2015
"Embryonic Stem Cell Lines Derived from Human Blastocytes" (1998), by James Thomson Ke Wu After becoming chief pathologist at the University of Wisconsin-Madison Wisconsin Regional Primate Center in 1995, James A. Thomson began his pioneering work in deriving embryonic stem cells from isolated embryos. That same year, Thomson published his first paper, "Isolation of a Primate Embryonic Stem Cell Line," in Proceedings of the National Academy of Sciences of the United States of America, detailing the first derivation of primate embryonic stem cells. In the following years, Thomson and his team of scientists - Joseph Itskovitz-Eldor, Sander S. Shapiro, Michelle A. 2011-02-01 9 April 2015
"The Effects of Wing Bud Extirpation on the Development of the Central Nervous System in Chick Embryos" (1934), by Viktor Hamburger Lijing Jiang German embryologist Viktor Hamburger came to the US in 1932 with a fellowship provided by the Rockefeller Foundation. Hamburger started his research in Frank Rattray Lillie's laboratory at the University of Chicago. His two-year work on the development of the central nervous system (CNS) in chick embryos was crystallized in his 1934 paper, "The Effects of Wing Bud Extirpation on the Development of the Central Nervous System in Chick Embryos," published in The Journal of Experimental Zoology. 2010-11-22 7 April 2015
"Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts" (2007), by Masato Nakagawa et al. Samuel Philbrick In November 2007, Masato Nakagawa, along with a number of other researchers including Kazutoshi Takahashi, Keisuke Okita, and Shinya Yamanaka, published "Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts" (abbreviated "Generation") in Nature. In "Generation," the authors point to dedifferentiation of somatic cells as an avenue for generating pluripotent stem cells useful for treating specific patients and diseases. 2010-11-20 7 April 2015
"β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis" (2007), by Kyle A. Gurley, Jochen C. Rink, and Alejandro Sánchez Alvarado Mary E. Sunderland Alejandro Sánchez Alvarado's laboratory group has employed molecular tools to investigate old questions about regeneration and as a result have identified some of the molecular mechanisms determining polarity. Recent work by his group has shown Wnt-β-catenin signaling determines whether a tail or a head will form during regeneration in planarians. This study was motivated by work Thomas Hunt Morgan conducted in the late nineteenth century. 2010-03-15 1 April 2015
Amphioxus, and the Mosaic Theory of Development (1893), by Edmund Beecher Wilson James Lowe Edmund Beecher Wilson experimented with Amphioxus (Branchiostoma) embryos in 1892 to identify what caused their cells to differentiate into new types of cells during the process of development. Wilson shook apart the cells at early stages of embryonic development, and he observed the development of the isolated cells. He observed that in the normal development of Amphioxus, all three main types of symmetry, or cleavage patterns observed in embryos, could be found. Wilson proposed a hypothesis that reformed the Mosaic Theory associated with Wilhelm Roux in Germany. 2015-03-31 31 March 2015
"Contributions to the Development of the Embryo. On the Artificial Production of One of the First Two Blastomeres, and the Later Development (Postgeneration) of the Missing Half of the Body" (1888), by Wilhelm Roux Megan Kearl Wilhelm Roux was an influential figure in the early history of experimental embryology. Although he originally studied medicine, he was invited to be a Privatdozentur, or unsalaried lecturer, at the Anatomical Institute in Breslau (Wroclaw), Poland, in 1879. He spent the next ten years at this institute, working his way from Dozent to associate professor and finally, in 1889, to director for his own institute, Institut für Entwicklungsgeschichte, or Institute for Developmental History and Mechanics. 2009-07-20 19 March 2015
"Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (t12/t12)-Normal Mosaics" (1964), by Beatrice Mintz Adam R. Navis The paper "Formation of Genetically Mosaic Mouse Embryos and Early Development of Lethal (t12/t12)-Normal Mosaics," by Beatrice Mintz, describes a technique to fuse two mouse embryos into a single embryo. This work was published in the Journal of Experimental Zoology in 1964. When two embryos are correctly joined before the 32-cell stage, the embryo will develop normally and exhibit a mosaic pattern of cells as an adult. 2009-01-13 18 March 2015
"Experimental Chimeras' Removal of Reproductive Barrier Between Sheep and Goat" (1984), by Sabine Meinecke-Tillmann and Burkhard Meinecke Nicole Newkirk In 1984 Sabine Meinecke-Tillmann and Burkhard Meinecke published their article "Experimental Chimeras - Removal of Reproductive Barrier Between Sheep and Goat" in Nature. Their study conquered the reproductive barrier between sheep and goats through embryo manipulation. Their article appeared in Nature on the same day that a similar experiment, conducted by Carole Fehilly, Steen Willadsen, and Elizabeth Tucker was published regarding reproductive barriers between sheep and goats. 2008-02-28 18 March 2015