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James Graves Wilson's six principles of teratology, published in 1959, guide research on teratogenic agents and their effects on developing organisms…
TeratologyAbnormalities, HumanCongenital AbnormalitiesBirth DefectsCongenital DefectsTeratogens are substances that may produce physical or functional defects in the human embryo or fetus after the pregnant woman is exposed to the…
Abnormalities, HumanFetusPregnancyTeratogenicity testingEmbryosThe concept Fetal Alcohol Syndrome (FAS) refers to a set of birth defects that occur in children born to mothers who abused alcohol during pregnancy…
fetal alcohol syndromeAbnormalities, HumanCentral Nervous SystemalcoholPregnancyEnvironment and Birth Defects by James Graves Wilson in the US was published in 1973. The book summarized information on the causes of malformations…
LiteratureBirth DefectsAbnormalities, HumanTeratogensTeratologyVitamin A (retinol) is an essential vitamin in the daily functioning of human beings that helps regulate cellular differentiation of epithelial…
RetinoidsVitamin A in the bodyTeratogenicity testingAbnormalities, HumanTeratogenic agentsMichael R. Harrison worked as a pediatric surgeon in the US throughout the late-twentieth century and performed many fetal surgeries, including one…
Birth DefectsAbnormalities, HumanPediatric surgeonsMyelomeningoceleSpinal DysraphismThalidomide is a sedative drug introduced to European markets on 1 October 1957 after extensive testing on rodent embryos to ensure its safety. Early…
ContextTeratogenicity testingAbnormalities, HumanThalidomide--Side effectsThalidomideJosef Warkany studied the environmental causes of birth defects in the United States in the twentieth century. Warkany was one of the first…
Abnormalities, HumanVitamin ARetinoidsHypervitaminosiscalomelIn 1980, Ernesto Ippolito and Ignacio Ponseti published their results on a histological study they performed on congenital club foot in human fetuses…
ClubfootPonseti, I. V. (Ignacio V.), 1914-2009Abnormalities, HumanHistologyHistology, PathologicalThe article Experimental Studies on Congenital Malformations was published in the Journal of Chronic Diseases in 1959. The author, James G. Wilson,…
LiteratureAbnormalities, HumanBirth DefectsTeratologymalformations