The Source-Sink Model

By Jack Resnik
Published: 2012-05-07
Keywords: Morphogenesis, Differentiation

The source-sink model, first proposed by biologist Francis Crick in 1970, is a theoretical system for how morphogens distribute themselves across small fields of early embryonic cells. A morphogen is a substance that determines the fate and phenotype of a group of cells through a concentration gradient of itself across that group. Crick’s theory has been experimentally confirmed with several morphogens, most notably with the protein bicoid , the first discovered morphogen. The model provides a theoretical structure for the understanding of some features of early embryonic development.

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Resnik, Jack, "The Source-Sink Model". Embryo Project Encyclopedia (2012-05-07). ISSN: 1940-5030

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Arizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.


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Crick, Francis, 1916-2004; Nobel Prize winners; Embryos; Morphogenesis; Genes; Embryology; Cell differentiation; Embryological development; Nüsslein-Volhard, C. (Christiane); Concept