Robert Geoffrey Edwards's Study of in vitro Mammalian Oocyte Maturation, 1960 to 1965

By Lijing Jiang
Published: 2014-08-18
Keywords: human oocyte maturation

In a series of experiments between 1960 and 1965, Robert Geoffrey Edwards discovered how to make mammalian egg cells, or oocytes, mature outside of a female's body. Edwards, working at several research institutions in the UK during this period, studied in vitro fertilization (IVF) methods. He measured the conditions and timings for in vitro (out of the body) maturation of oocytes from diverse mammals including mice, rats, hamsters, pigs, cows, sheep, and rhesus monkeys, as well as humans. By 1965, he manipulated the maturation of mammalian oocytes in vitro, and discovered that the maturation process took about the same amount of time as maturation in the body, called in vivo. The timing of human oocyte maturation in vivo, extrapolated from Edwards's in vitro study, helped researchers calculate the timing for surgical removal of human eggs for IVF.

How to cite

Jiang, Lijing, "Robert Geoffrey Edwards's Study of in vitro Mammalian Oocyte Maturation, 1960 to 1965". Embryo Project Encyclopedia (2014-08-18). ISSN: 1940-5030 http://embryo.asu.edu/handle/10776/8147.

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Publisher

Arizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia.

Rights

Copyright Arizona Board of Regents Licensed as Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported (CC BY-NC-SA 3.0) http://creativecommons.org/licenses/by-nc-sa/3.0/

Last modified

Monday, August 18, 2014 - 21:50

Topic

Experiments, Reproduction

Subject

Fertilization in Vitro; In Vitro Oocyte Maturation Techniques; Oocytes; Luteinizing Hormone; Edwards, R. G. (Robert Geoffrey), 1925-2013; Pincus, Gregory, 1903-1967; Experiment